Composition for accelerating catabolism of fat, preparation method and application

Abstract

The invention belongs to the technical field of functional food, and particularly relates to a composition for accelerating fat catabolism, a preparation method and application, the composition comprises the following components: mitochondria nutrients, oat peptide and oat glucan, medicinal and edible nutrition components and a carbon-water blocking agent; wherein the mitochondrial nutrient is prepared from the following raw materials: coenzyme Q10, nicotinamide adenine dinucleotide, acetylcysteine, L-carnitine, creatine, vitamin B group and chromium nicotinate. The preparation method of the composition comprises the following steps: mixing the raw materials in the medicinal and edible nutrient components, then mixing with the oat peptide, the oat glucan and the mitochondria nutrient, and drying to obtain the composition. All the components cooperate with one another, mitochondrial regeneration is promoted, islet cell repair is promoted, and the immune function and the cell metabolism function are recovered. Besides, the traditional Chinese medicine composition has a fat burning effect, the weight and the fat content are remarkably reduced, toxins wrapped by fat in the body can be eliminated, free radicals in cells can be eliminated, and the traditional Chinese medicine composition has a good application prospect.

Description

Technical Field

[0001] The invention belongs to the technical field of functional foods, and in particular relates to a composition for accelerating fat decomposition and metabolism, a preparation method and application thereof. Background Art

[0002] Obesity is a disease in which the body gains weight due to excessive accumulation of fat in the body. It is related to eating habits, medications, reduced exercise, and imbalanced intestinal flora. With the onset of obesity, a series of lipid metabolism disorders will occur, leading to increased blood lipid levels, fatty degeneration of the liver, etc. In addition, obesity is closely related to a series of metabolic diseases such as type 2 diabetes, cardiovascular disease, and non-alcoholic fatty liver. At present, the main treatments for obesity include drug therapy, increased exercise, and surgical treatment, but the results are not satisfactory. Therefore, it is of great significance to intervene or control from a dietary perspective in daily life, especially to use food to prevent or intervene in the improvement of obesity.

[0003] In addition to negative energy balance, there are many other phenomena in fat production that cannot be fully explained by diet and exercise, including fatty liver in thin people, a significant increase in childhood obesity, and many people who do not seem to be obese but have many metabolic chronic diseases. The present invention found that many causes are related to the intake of specific substances by the human body. The above-mentioned specific substances include: 1. Food additives; 2. Antibiotic residues in industrially farmed poultry and meat; 3. Agricultural residues in off-season fruits and vegetables in greenhouses; 4. Western medicine; 5. Environmental pollution, especially heavy metals, detergents, and chemical synthetics in soil, water, and air. Long-term intake of the above-mentioned specific substances leads to cellular oxidative stress, inflammation, increased fat ratio, defective insulin action (insulin resistance), and impaired liver function, which in turn leads to metabolic chronic diseases characterized by increased visceral fat.

[0004] Chinese invention patent applications CN108112996A and CN118633734A both use white kidney bean extract as an amylase blocker to reduce the gastrointestinal tract's decomposition and absorption of starch ingested during meals. However, there are the following problems: 1. Starch blockers must be taken every time starchy staples or snacks are ingested. If they are not taken with meals or more than 1 hour before or after meals, they will become ineffective; 2. They are not helpful for the repair of pancreatic β cells and the restoration of insulin secretion function; and the effect on fat degradation is not obvious enough.

[0005] Chinese invention patent application CN 118648694A discloses a composition method and preparation method for promoting fat burning, which uses longan powder, ginger oil microcapsule powder, 20-80 parts of L-carnitine and citrus cinnamon composite powder as a formula to make the body feel hot, increase body temperature and accelerate basal metabolism to achieve the effect of fat reduction, but it does not supplement enough factors such as sufficient mitochondrial combustion and enterohepatic circulation, and still has some defects.

[0006] Although fat reduction has a realistic market application and fat reduction technology has shown good application prospects, most of the existing functional food formulas focus on satiety and excretion promotion, and there is little research and application on fat generation, especially fat degradation as an energy supply nutrient. Therefore, providing a composition formula that accelerates fat decomposition and metabolism has a good reference value for the research of fat reduction products. Summary of the invention

[0007] In view of the deficiencies in the prior art, the present invention provides a composition for accelerating fat decomposition and metabolism, a preparation method and application thereof.

[0008] In order to achieve the purpose of the present invention, the technical solution adopted is as follows:

[0009] A composition for accelerating fat decomposition metabolism, comprising the following components: mitochondrial nutrients, oat peptides and oat glucan, medicinal and edible nutrient components and a carbohydrate blocker; wherein the raw materials of the mitochondrial nutrients include coenzyme Q10, NAD+, acetylcysteine, L-carnitine, creatine, vitamin B group and chromium nicotinate.

[0010] Preferably, the medicinal and edible nutritional components are selected from several of psyllium husk powder, inulin, diglyceride, mulberry leaf, konjac gum, green coffee, cassia seed, citrus fiber, honeysuckle pollen, tea polyphenols, linseed, cyperus oleifera, ginsenoside, blueberry, γ-aminobutyric acid, and jujube seed powder.

[0011] Preferably, the carbohydrate blocking agent comprises white kidney bean extract, L-arabinose and marine probiotics.

[0012] Preferably, the supplier of marine probiotics is Fujian Huisheng Biotechnology Co., Ltd., model HS-HJ01.

[0013] Preferably, the mitochondrial nutrients include coenzyme Q10, NAD+, acetylcysteine, L-carnitine, creatine, vitamin B group, and chromium nicotinate in parts by weight;

[0014] Preferably, the medicinal and edible nutritional components include psyllium husk powder, diglyceride, mulberry leaf, konjac gum, green coffee, cassia seed, citrus fiber, honeysuckle pollen, linseed, cyperus oleifera and ginsenoside;

[0015] Preferably, the carbohydrate blocking agent comprises white kidney bean extract, L-arabinose and marine probiotics.

[0016] Preferably, the mass ratio of coenzyme Q10, nicotinamide adenine dinucleotide, acetylcysteine, L-carnitine, creatine, vitamin B group and chromium nicotinate is 5-8: 0.1-0.5: 2-4: 5-8: 25-30: 3-4: 0.03-0.05.

[0017] Preferably, the medicinal and edible nutritional components include psyllium husk powder, diglyceride, mulberry leaf, konjac gum, green coffee, cassia seed, citrus fiber, honeysuckle pollen, linseed, cyperus oleifera and ginsenoside, and the mass ratio is 20-30:15-20:4-10:6-12:10-15:4-8:1-3:2-5:3-5:4-10:0.5-1;

[0018] Preferably, the carbohydrate blocking agent comprises white kidney bean extract, L-arabinose and marine probiotics in a mass ratio of 10-15:30-50:40-45.

[0019] Preferably, the composition comprises the following components by weight: 1-5 parts of mitochondrial nutrients, 5-30 parts of oat peptides and oat glucan, 50-75 parts of medicinal and edible nutritional components and 5-15 parts of carbohydrate blockers.

[0020] Preferably, the composition comprises the following components by weight: 2-3 parts of mitochondrial nutrients, 8-27 parts of oat peptides and oat glucan, 55-72 parts of medicinal and edible nutritional components and 5-9 parts of carbohydrate blockers.

[0021] Preferably, the raw materials of the composition further include 8-12 parts by weight of natural sweetener.

[0022] Preferably, the natural sweetener is L-arabinose.

[0023] Preferably, the preparation method of the oat peptide and oat glucan comprises adding 60-100 mesh oat flour to 20-30 times the mass of 35-55° C. water, filtering by ultrasound, ultrafiltration membrane and diatomaceous earth plate and frame, and further freeze-drying the filtrate.

[0024] The second object of the present invention is to provide a method for preparing the above-mentioned composition, comprising mixing the raw materials in the medicinal and edible nutritional components, then mixing with oat peptides and oat glucan, mitochondrial nutrients and carbohydrate blockers, and drying to obtain the composition.

[0025] Preferably, the above components are further sieved, and the mesh number of the sieve is 80-100 mesh.

[0026] Preferably, the drying temperature is 60-70°C.

[0027] Preferably, the product is further sterilized by irradiation after drying.

[0028] The third object of the present invention is to provide use of the above composition in preparing products that promote fat burning or accelerate fat decomposition and metabolism.

[0029] Another object of the present invention is to provide a product for accelerating fat decomposition and metabolism, which comprises the composition and a food-acceptable auxiliary material.

[0030] Preferably, the food-acceptable auxiliary material is selected from one or more of erythritol, glycerin, pectin, sodium alginate, polydextrose, carrageenan, sodium ascorbate, L-malic acid, maltitol, gelatin, xylitol, citric acid, potassium citrate, sodium citrate, sorbic acid and its potassium salt, sorbitol, calcium carbonate, vitamin C, vitamin E, and magnesium stearate.

[0031] Preferably, the product may also contain other food ingredients.

[0032] Preferably, the product is a solid beverage, a liquid beverage, a compressed candy, an energy bar, a baked product or a biscuit.

[0033] Compared with the prior art, the present invention has the following beneficial effects:

[0034] (1) The present invention uses mitochondrial nutrients, oat peptides and glucan, medicinal and edible ingredients, carbohydrate blockers and other components to work together to promote mitochondrial regeneration, promote pancreatic cell repair, and restore immune function and cell metabolic function.

[0035] (2) The formula of the present invention has the effect of burning fat, significantly reducing body weight, eliminating toxins wrapped in fat in the body, and removing free radicals in cells.

[0036] (3) Various raw materials of the present invention, such as oat peptides and oat glucan, also have the effect of restoring blood sugar control, balancing and stabilizing blood sugar, and are more suitable for preparing functional foods for fat reduction and nutritional supplementation. DETAILED DESCRIPTION

[0037] The present invention is further described below in conjunction with specific embodiments. The raw materials in the following examples are all commercially available conventional raw materials.

[0038] Numerical ranges used herein should be understood to include all numbers within the range. For example, a range of 1 to 20 should be understood to include any number, combination of numbers, or subrange from the following group: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20.

[0039] The terms "optional", "either", "any", or "any" as used herein mean that the subsequently described event or circumstance may but need not occur, and that the description includes instances where the event or circumstance occurs or does not occur. As used herein, "a" and "an" are used herein to refer to one or more than one of the grammatical objects.

[0040] The term "and / or" used herein should be understood to mean any one of the optional items or a combination of any two or more of the optional items.

[0041] The purchase information of the main raw materials of the present invention is shown in Table 1, wherein the composition of the mitochondrial nutrients is coenzyme Q10, nicotinamide adenine dinucleotide, acetylcysteine, L-carnitine, creatine, vitamin B group and chromium nicotinate.

[0042] Table 1 Raw materials used in the present invention

[0043] Components factory Part Number Mitochondrial nutrients Anhui Fengyuan Group Co., Ltd. -- Oat peptides and oat beta-glucan Zhangjiakou Beta Biotechnology Co., Ltd. BT24015006 Psyllium husk powder Xi'an Xuhuang Biotechnology Co., Ltd. XH2369872B Diacylceride Shaanxi Haisifu Bioengineering Co., Ltd. MDG-CR20 Mulberry Leaves Bozhou Boyuantong Chinese Medicinal Herbs Planting Co., Ltd. - Green Coffee Shandong Kangmei Pharmaceutical 430310194 Cassia seed Shandong Kangmei Pharmaceutical 81100411 Citrus Fiber Guangdong Mingtong Biological MT-XW25 Honeysuckle Pollen Xi'an Youshuo Biotechnology Co., Ltd. YS432435 Chia flax seeds Jining Yijianyuan 69334303 Cyperus oleifera Tangshan Qifayuan Oil Bean Planting Farmers Cooperative YS052612 Ginsenosides Xi'an Anao Biotechnology Co., Ltd. QAD-0917 Marine probiotics Fujian Huisheng Biotechnology Co., Ltd. HS-HJ01 White Kidney Bean Extract Biological Resources of Betula truncatula 410RCE005 Blueberry Extract Shaanxi Chenming Biotechnology Co., Ltd. 281-983-5 Konjac Gum Wuhan Jiangshu Food Ingredients Co., Ltd. JS2170024

[0044] Example 1

[0045] A composition for accelerating fat decomposition metabolism, the raw materials of which are: a) 2 parts by weight of mitochondrial nutrients, b) 8 parts by weight of oat peptides and oat glucan, c) 72 parts by weight of medicinal and edible components, d) 8 parts by weight of a carbohydrate blocker, and e) 10 parts by weight of a natural sweetener, L-arabinose.

[0046] Among them, the medicinal and edible nutritional components are psyllium husk powder, diglyceride, mulberry leaf, konjac gum, green coffee, cassia seed, citrus fiber, honeysuckle pollen, linseed, cyperus oleifera and ginsenoside in a mass ratio of 25:18:7:9:12:6:2:3:4:7:0.6;

[0047] The carbohydrate blocker is white kidney bean extract, L-arabinose and marine probiotics in a mass ratio of 12:40:42.

[0048] The preparation method is:

[0049] (1) weighing component b) oat peptide and oat glucan for later use;

[0050] (2) weighing component c) the medicinal and edible nutritional component and mixing the components;

[0051] (3) weighing components a) mitochondrial nutrients and e) natural sweetener, and further mixing components a) and e) with the mixture obtained in the above steps (1) and (2);

[0052] (4) drying the product of step (3) at 60° C.;

[0053] (5) The product of step (4) is further sterilized by irradiation and packaged.

[0054] The mesh size of each component screened in the above steps (1) to (3) is 80 mesh.

[0055] Example 2

[0056] A composition for accelerating fat decomposition metabolism, the raw materials of which are: a) 3 parts by weight of mitochondrial nutrients, b) 18 parts by weight of oat peptides and oat glucan, c) 60 parts by weight of medicinal and edible components, d) 9 parts by weight of a carbohydrate blocker, and e) 10 parts by weight of a natural sweetener, L-arabinose.

[0057] Among them, the edible and medicinal nutritional components are composed of psyllium husk powder, diglyceride, mulberry leaves, konjac gum, green coffee, cassia seed, citrus fiber, honeysuckle pollen, linseed, cyperus oleifera and ginsenosides in a mass ratio of 20:15:4:6:10:4:1:2:3:4:0.5; the carbohydrate blocker is composed of white kidney bean extract, L-arabinose and marine probiotics in a mass ratio of 10:30:40.

[0058] The preparation method is:

[0059] (1) weighing component b) oat peptide and oat glucan for later use;

[0060] (2) weighing component c) the medicinal and edible nutritional component and mixing the components;

[0061] (3) weighing components a) mitochondrial nutrients and e) natural sweetener, and further mixing components a) and e) with the mixture obtained in the above steps (1) and (2);

[0062] (4) drying the product of step (3) at 70° C.;

[0063] (5) The product of step (4) is further sterilized by irradiation and packaged.

[0064] The mesh size of each component sieved in the above steps (1) to (3) is 100 mesh.

[0065] Example 3

[0066] A composition for accelerating fat decomposition metabolism, the raw materials of which are: a) 3 parts by weight of mitochondrial nutrients, b) 27 parts by weight of oat peptides and oat glucan, c) 55 parts by weight of medicinal and edible components, d) 5 parts by weight of carbon water blockers, and e) 10 parts by weight of natural sweeteners. Among them, the medicinal and edible nutrient components are psyllium husk powder, diglyceride, mulberry leaf, konjac gum, green coffee, cassia seed, citrus fiber, honeysuckle pollen, linseed, cyperus oleifera and ginsenoside in a mass ratio of 30:20:10:12:15:8:3:5:5:10:1; the carbon water blocker is composed of white kidney bean extract, L-arabinose and marine probiotics in a mass ratio of 15:50:45.

[0067] The preparation method is:

[0068] (1) weighing component b) oat peptide and oat glucan for later use;

[0069] (2) weighing component c) the medicinal and edible nutritional component and mixing the components;

[0070] (3) weighing components a) mitochondrial nutrients and e) natural sweetener, and further mixing components a) and e) with the mixture obtained in the above steps (1) and (2);

[0071] (4) drying the product of step (3) at 70° C.;

[0072] (5) The product of step (4) is further sterilized by irradiation and packaged.

[0073] The mesh size of each component sieved in the above steps (1) to (3) is 100 mesh.

[0074] Comparative Example 1

[0075] The difference from Example 1 is that Comparative Example 1 does not contain a) mitochondrial nutrients, and the amount of b) oat peptides and oat glucan is equal to the total amount of a) mitochondrial nutrients and b) oat peptides and oat glucan in Example 1.

[0076] Comparative Example 2

[0077] The difference from Example 1 is that Comparative Example 1 does not contain b) oat peptides and oat glucan, and the amount of a) mitochondrial nutrients is equal to the total amount of a) mitochondrial nutrients and b) oat peptides and oat glucan in Example 1.

[0078] Comparative Example 3

[0079] The blank control group, in the following test examples, only animal feed was added.

[0080] Test example

[0081] The experimental animal model was purchased from Hangzhou Qizhen Experimental Animal Technology Co., Ltd., with an average weight of 30-35 grams, half male and half female, 10 mice in each group, and randomly divided into 6 groups. One group was taken as the blank group (10 mice) and given normal feed, and the remaining 5 groups were high-fat groups (60 mice) and given high-fat feed; after 8 weeks, the body weight index was tested to confirm that the high-fat mouse model was successfully established.

[0082] 2 g of the composition for accelerating fat decomposition metabolism prepared according to the formula of Examples 1-3 and Comparative Examples 1-3 was mixed into 8 g of feed every day and fed freely to the high-fat group. The observation was continued for 14 days. Calculated by weight, 2 g of the composition for accelerating fat decomposition metabolism is equivalent to 10 times the human dose.

[0083] The results of body weight observation (g) are shown in Table 1.

[0084] Table 1 Weight monitoring table of mice in each group

[0085]

[0086] Note: Compared with the blank group, *P<0.05, **P<0.01.

[0087] The above mouse experiments show that:

[0088] During the experiment, no animal withdrew from the experiment early due to abnormality. At the end, the overall condition of the experimental animals and the mice using the nutrients of the present invention as dietary supplements showed the strengthening and synergistic effects between the nutrients. It can be seen from the above effect data that based on the total weight of a) mitochondrial nutrients and b) oat peptides and oat glucan being 100 parts by weight, the addition ratio of a to b is: 1:99-10:90; the weight of the experimental mice has decreased significantly. In a more preferred embodiment, the ratio of a to b is: 10:90-30:70.

[0089] The above results indicate that the composition based on mitochondrial nutrients, oat peptides and oat glucan can promote accelerated decomposition and metabolism of fat, and finally effectively inhibit the weight gain of mice.

[0090] The above detailed description is a specific description of one feasible embodiment of the present invention. The embodiment is not intended to limit the patent scope of the present invention. Any equivalent implementation or modification that does not deviate from the present invention should be included in the scope of the technical solution of the present invention.

Claims

1. A composition for accelerating fat decomposition metabolism, characterized in that: The composition comprises the following components: mitochondrial nutrients, oat peptides and oat glucan, medicinal and edible nutrient components and a carbohydrate blocker; wherein the raw materials of the mitochondrial nutrients include coenzyme Q10, nicotinamide adenine dinucleotide, acetylcysteine, L-carnitine, creatine, vitamin B group and chromium nicotinate.

2. The composition according to claim 1, characterized in that The medicinal and edible nutritional components are selected from several of psyllium husk powder, inulin, diglyceride, mulberry leaf, konjac gum, green coffee, cassia seed, citrus fiber, honeysuckle pollen, tea polyphenols, linseed, cyperus oleifera, ginsenoside, blueberry, gamma-aminobutyric acid, and jujube seed powder.

3. The composition according to claim 1, characterized in that The carbohydrate blocking agent comprises white kidney bean extract, L-arabinose and marine probiotics.

4. The composition according to claim 3, characterized in that The marine probiotics are Lactobacillus plantarum, model HS-HJ01.

5. The composition according to claim 1, characterized in that The raw materials of mitochondrial nutrients include coenzyme Q10, Nicotinamide adenine dinucleotide, acetylcysteine, L-carnitine, creatine, B vitamins and chromium nicotinate; The mass ratio of coenzyme Q10, nicotinamide adenine dinucleotide, acetylcysteine, L-carnitine, creatine, vitamin B group and nicotinic acid chromium is 5-8: 0.1-0.5: 2-4: 5-8: 25-30: 3-4: 0.03-0.05; And / or, the medicinal and edible nutritional components include psyllium husk powder, diglyceride, mulberry leaf, konjac gum, green coffee, cassia seed, citrus fiber, honeysuckle pollen, linseed, cyperus oleifera and ginsenoside, with a mass ratio of 20-30:15-20:4-10:6-12:10-15:4-8:1-3:2-5:3-5:4-10:0.5-1; And / or, the carbohydrate blocking agent comprises white kidney bean extract, L-arabinose and marine probiotics in a mass ratio of 10-15:30-50:40-45.

6. The composition according to claim 1, characterized in that The composition comprises the following components by weight: 1-5 parts of mitochondrial nutrients, 5-30 parts of oat peptides and oat glucan, 50-75 parts of medicinal and edible nutritional components and 5-15 parts of carbohydrate blockers.

7. The composition according to claim 1, characterized in that The composition comprises the following components by weight: 2-3 parts of mitochondrial nutrients, 8-27 parts of oat peptides and oat glucan, 55-72 parts of medicinal and edible nutrient components, and 5-9 parts of carbohydrate blockers; And / or, the raw materials of the composition further include 8-12 parts by weight of natural sweetener.

8. A method for preparing the composition according to any one of claims 1 to 7, characterized in that: The method comprises mixing various raw materials of the edible-medicinal homologous nutritional components, then mixing with oat peptides, oat glucan, mitochondrial nutrients and a carbohydrate blocker, and drying at 60-70°C to obtain the product.

9. Use of the composition according to any one of claims 1 to 7 in preparing a product for promoting fat burning or accelerating fat decomposition and metabolism.

10. A product for accelerating fat decomposition metabolism, characterized in that: The product comprises any one of claims 1 to 8 The composition and the food-acceptable excipients; The food-acceptable auxiliary material is selected from one or more of erythritol, glycerin, pectin, sodium alginate, polydextrose, carrageenan, sodium ascorbate, L-malic acid, maltitol, gelatin, xylitol, citric acid, potassium citrate, sodium citrate, sorbic acid and its potassium salt, sorbitol, calcium carbonate, vitamin C, vitamin E, and magnesium stearate; And / or the product is a solid beverage, a liquid beverage, a compressed candy, an energy bar, a baked product or a biscuit.

Images