Multivalent nano-antibody modified plasmon nano-probe as well as preparation method and application of multivalent nano-antibody modified plasmon nano-probe

Abstract

The invention discloses a multivalent nano antibody modified plasmon nano probe and a preparation method and application thereof, and belongs to the technical field of plasmon nano probes, the preparation method of the probe comprises the following steps: S1, preparing a multivalent nano antibody for targeted recognition of a target protein marker; s2, the surface of a plasmon nano material is modified with multivalent nano antibodies, a plasmon nano probe is prepared, the probe is provided with multiple multivalent nano antibodies and multiple binding fragments, can recognize multiple epitopes of antigens and has the advantages of being high in affinity, specificity and stability, and the problems that a monovalent nano antibody is simple in structure, only one antigen binding fragment exists, and the cost is low are solved. Only the same epitope of the antigen can be recognized, the affinity is poor, and the specificity is not strong.

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