Manufacturing method of polymer microspheres with uniform and controllable size and polymer microspheres prepared by same

Abstract

The invention discloses a manufacturing method of polymer microspheres, which mainly comprises the following steps: (1) preparing a continuous phase: adding a stabilizer into an aqueous solution to obtain the continuous phase; preparing a dispersion phase: adding an oil-soluble initiator, a polymeric monomer and an auxiliary agent into the oily solution; (2) adopting a tubular porous glass membrane tube as a microporous membrane, arranging the continuous phase outside the membrane tube, arranging the dispersed phase in the membrane tube, and rapidly passing through the microporous membrane under constant pressure to obtain O / W type emulsion; (3) polymerizing and curing the O / W type emulsion to prepare uniform polymer microspheres; and (4) filtering, washing and drying the polymer microspheres. By adopting the method disclosed by the invention, a polymer microsphere product with uniform and controllable size can be obtained, the average particle size is 1-40 microns, and the particle size distribution coefficient is 10%-20%; the use requirements in the fields of biological medicines, functional materials and the like are completely met.

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