Screening method of anti-monkey pox virus medicine

Abstract

The invention discloses a screening method of an anti-monkey pox virus drug, which comprises the following steps: acquiring a genome of monkey pox virus, predicting a three-dimensional structure of a gene encoding protein in the genome, screening an encoding protein capable of interacting with human protein by using the three-dimensional structure of the encoding protein and reversely deducing to obtain a corresponding encoding gene, and then screening the anti-monkey pox virus drug by using the corresponding encoding gene to obtain the anti-monkey pox virus drug. Calculating the dN / dS ratio of the coding gene, and selecting the coding gene with the dN / dS ratio greater than 1 as a target gene; screening a drug combined with the three-dimensional structure of the target gene coding protein by using a molecular docking technology to obtain an antiviral drug; according to the screening method of the anti-monkey-pox-virus drug, the anti-monkey-pox-virus drug can be rapidly screened from drugs sold in the market by utilizing a molecular evolution theory, protein-protein interaction and docking of protein and the drug, vaccines are avoided, the research and development time is shortened, the cost is reduced, and the screening method is suitable for large-scale popularization and application of the anti-monkey-pox-virus drug. The screening method is rapid and reliable, has no side effect, is relatively low in price, and can rapidly find the specific medicine for resisting the monkey pox virus.