一种基于中空介孔聚多巴胺纳米粒的给药系统的制备方法和应用
By loading piracetam and galantamine hydrobromide into hollow mesoporous polydopamine nanoparticles and combining them with pectin to form a targeted drug delivery system, the problems of large drug side effects, high price and low drug delivery efficiency in IBD treatment are solved. This achieves intestinal neuron repair and immune function regulation, improving treatment efficacy and safety.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- NANJING TECH UNIV
- Filing Date
- 2024-11-28
- Publication Date
- 2026-07-17
AI Technical Summary
Existing IBD treatments have strong side effects, biologics are expensive and have poor administration efficiency, and traditional treatments are ineffective for some patients and cannot effectively restore intestinal neuroimmune function.
Hollow mesoporous polydopamine nanoparticles are used to load piracetam, a neuroprotective drug, and galantamine hydrobromide, an acetylcholinesterase inhibitor, into the nanoparticles. Combined with pectin, an enteric material, a targeted drug delivery system is formed. This system achieves targeted drug delivery and sustained release by repairing the intestinal neural network structure and regulating immune cell function.
It significantly restores intestinal neuronal structure, regulates immune cell function, reduces pro-inflammatory cytokines, improves drug delivery efficiency, reduces side effects, lowers the risk of chronic diseases, and improves intestinal health.
Smart Images
Figure CN119499212B_ABST