转运蛋白ABCH与LMNG复合物结构、去垢剂分子LMNG作为杀虫剂的应用
By designing a complex of LMNG and the insect adenosine triphosphate binding cassette superfamily transporter ABCH, the problem of insecticide resistance was solved, and a highly effective insecticidal effect was achieved against the larvae of the red flour beetle and the diamondback moth.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- AGRI GENOMICS INST CHINESE ACADEMY OF AGRI SCI
- Filing Date
- 2024-11-22
- Publication Date
- 2026-07-17
AI Technical Summary
The increasing resistance of pests to chemical pesticides is leading to reduced crop yields and environmental pollution, necessitating the development of inhibitors targeting new pests to address pesticide resistance in agricultural pests.
We designed a complex of the detergent molecule lauryl maltose neopentyl glycol (LMNG) and the insect adenosine triphosphate binding cassette superfamily transporter ABCH. Through three-dimensional structural analysis and binding site information, we developed an insecticide targeting ABCH.
LMNG significantly inhibited the ATP hydrolysis activity of ABCH, resulting in a 60% mortality rate in red flour beetle larvae and a 90% mortality rate in diamondback moth larvae, providing a highly effective insecticidal effect.
Smart Images
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