Thiazole compound, SUMO-removing and / or ubiquitinating enzyme-removing inhibitor, and preparation method and application thereof

Abstract

The invention discloses a thiazole compound, a SUMO-removing and / or ubiquitinating enzyme-removing inhibitor and a preparation method and application thereof, and belongs to the technical field of molecular biology and biological medicine. The thiazole compound has a structure # imgabs0 # as shown in a formula E, R is selected from one of C1-5 alkyl, heterocyclic alkyl, benzoheterocycle, substituted piperidine, substituted piperazine, phenyl, benzyl or H, and A is selected from one of benzene ring, piperidine or hydrogen. In addition, the invention also provides a synthesis method of the thiazole compound. In addition, the invention also provides an inhibitor for removing SUMO and / or deubiquitinating enzyme, which is one or more of the thiazole compounds. In addition, the invention also provides an application of the SUMO-removing and / or deubiquitinating enzyme inhibitor in preparation of drugs for inhibiting the activity of the SUMO-removing and / or deubiquitinating enzyme. The thiazole compound can effectively inhibit the activity of DESI2 enzyme.

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