抗ApoE4抗体或其功能性片段及其应用
By designing anti-ApoE4 antibodies or their antigen-binding fragments with specific amino acid sequence combinations, the problem of insufficient specificity of existing antibodies in ApoE4 detection has been solved, achieving efficient qualitative or quantitative detection of ApoE4 and meeting the precise needs of clinical diagnosis.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- ZYBIO INC
- Filing Date
- 2024-11-20
- Publication Date
- 2026-07-17
AI Technical Summary
Existing ApoE4-specific antibodies have low specificity in clinical testing and cannot meet the needs of accurate diagnosis, especially in the auxiliary diagnosis of Alzheimer's disease. Existing detection methods such as chemiluminescent immunoassay and immunochromatography are lacking in specificity and sensitivity.
An antibody against ApoE4 or its antigen-binding fragment was designed and prepared. By designing a complementarity-determining region (CDR) and a framework region (FR) with a specific combination of amino acid sequences, the binding specificity and affinity with ApoE4 were improved. This antibody can be used in detection methods such as immunochromatography, enzyme-linked immunosorbent assay (ELISA), and chemiluminescence immunoassay to enhance the sensitivity and specificity of detection.
This technology enables efficient qualitative or quantitative detection of ApoE4, improving the specificity and sensitivity of the detection and meeting the precision requirements of clinical diagnosis.
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