Application of periplaneta americana polypeptide and periplaneta americana peptide A as immunologic adjuvant

Abstract

The invention belongs to the technical field of biomedicine, and particularly relates to application of periplaneta americana polypeptide periplaneta americana peptide A as an immunologic adjuvant. The amino acid sequence of the periplaneta americana polypeptide periplaneta americana peptide A is shown as SEQ ID NO.1. The invention further discloses a preparation method of the periplaneta americana polypeptide periplaneta americana peptide A. According to the invention, influenza virus H1N1RBD protein is matched with periplaneta americana peptide A to induce mice to generate an anti-RBD protein specific IgG antibody with higher titer, and the titer is increased along with the increase of immunization times, so that the immunopotentiation effect is achieved, and mass production can be facilitated. The periplaneta americana polypeptide and periplaneta americana peptide A can be conveniently and massively synthesized and obtained, and can be used as a novel micromolecular immune adjuvant to enhance the specific immune response of an organism.

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