4-(4-氯噻吩-2-基)-5-(4-环己基哌嗪-1-基)噻唑-2-胺的合成方法
By using simple esterification, chlorination, carbonyl dichloroation, and substitution reactions, the complex and costly synthesis process of 4-(4-chlorothiophene-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazole-2-amine in existing technologies has been solved, enabling low-cost industrial production of high-purity products.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHENZHEN ZHIWEITONG TECH CO LTD
- Filing Date
- 2024-12-03
- Publication Date
- 2026-07-17
AI Technical Summary
Existing methods for synthesizing 4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazole-2-amine suffer from problems such as long process routes, high production costs, and numerous byproducts that are difficult to purify.
Using thiophene-2-carboxylic acid as the starting material, the target product is obtained through simple reactions such as esterification, chlorination, carbonyl dichloroation, cyclization, and substitution, using specific catalysts, chlorination reagents, strong bases, and solvents, and controlling the reaction conditions. Finally, the product is purified by recrystallization.
It achieves mild reaction conditions, simple operation, few side reactions, low cost, and is suitable for large-scale industrial production, with high product purity.
Smart Images
Figure CN119569720B_ABST