Ivabradine hydrochloride sustained-release pellet as well as preparation method and application thereof

Abstract

The invention provides an ivabradine hydrochloride sustained-release pellet and a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations, drugs are prepared into a sustained-release pellet preparation, the peak valley phenomenon of the plasma concentration of a common preparation can be effectively avoided, the plasma concentration can be kept for a long time, the medicine taking frequency is reduced, and the adverse reaction occurrence rate is reduced. The compliance of a patient is improved; the sustained-release pellet preparation provided by the invention belongs to a multi-unit sustained-release preparation, can avoid sudden release of drugs, and further ensures the safety of clinical medication; and the product has good stability and is equivalent to a commercially available quick-release preparation, namely, Lane. The preparation process is simple, ethanol used in the process is a conventional solvent, compared with other dichloromethane, acetone and the like, the toxicity is small, the safety is high, the technical difficulty is reduced, industrial mass production is easy to realize, and the market potential is large.

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