A method for the production of a ready-to-use artificial blood vessel with a silicone rubber elastomer intermediate layer

CN119593139BActive Publication Date: 2026-11-03HUBEI THREE GORGES LAB
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Patent Information

Application Number
CN202411454083.1
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-10-17
Publication Date
2026-11-03
Estimated Expiration
2044-10-17

AI Technical Summary

Technical Problem

Existing percutaneous artificial blood vessels require a 2-4 week waiting period before puncture, leading to complications such as the use of hemodialysis catheters during the transition period and central venous stenosis. Furthermore, traditional materials have poor biocompatibility.

Method used

A three-layer artificial blood vessel is fabricated layer by layer using electrospinning technology. The inner layer is thermoplastic polyurethane, the middle layer is a two-component room temperature/medium temperature addition-curing filled and reinforced silicone rubber, and the outer layer is thermoplastic polyurethane. The vessel is then formed into a wearable artificial blood vessel through high-temperature secondary vulcanization.

Benefits of technology

It enables puncture within 24 hours post-surgery, reducing the risk of edema and bleeding. The material has good elasticity matching with human arteries, good biocompatibility, and excellent mechanical properties, making it suitable for the field of tissue engineering.

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Abstract

The application relates to the field of medical devices, and particularly discloses a preparation method of a ready-to-use artificial blood vessel with a silicon rubber elastomer middle layer, which comprises the following steps: a three-layer ready-to-use artificial blood vessel is prepared on a multi-size tubular receiver by using an electrostatic spinning technology; the middle layer of the three-layer artificial blood vessel is prepared by using a double-channel electrostatic spinning technology, and a two-component room temperature / medium temperature addition type filling and reinforcing silicon rubber is synthesized to serve as a silicon rubber elastomer; and the inner and outer layers of the three-layer artificial blood vessel are prepared by using a thermoplastic polyurethane as raw material and electrostatic spinning treatment. The prepared ready-to-use three-layer artificial blood vessel has excellent physical and mechanical properties and biocompatibility, adopts a special middle-layer silicon glue structure, can make a puncture needle hole retract, immediately contracts and closes a puncture point after a puncture needle is pulled out to stop bleeding, avoids serum exosmosis, reduces the occurrence of postoperative limb edema, and reduces the risk of bleeding.
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Citation Information

Patent Citations

  • Preparation method of material for artificial blood vessel, artificial blood vessel prepared from material and application

    CN109793935A

  • Preparation method of real-time vulcanized elastomer fiber membrane

    CN114541043A

  • Electrostatic spinning method of silicone rubber tubular elastic fiber layer

    CN117822204A

  • Electrostatic spinning method of two-component silicone rubber

    CN118407143A