一种透明质酸钠栓塞微球的制备方法及制得的栓塞微球
By copolymerizing methacrylated sodium hyaluronate with negatively charged monomers, the problems of poor compressibility and low drug loading efficiency of microspheres were solved, and sodium hyaluronate embolization microspheres with high compressibility and high drug loading capacity were prepared.
CN119613620BActive Publication Date: 2026-07-17SHANGHAI FANGRUN INT INSTR CO LTD
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHANGHAI FANGRUN INT INSTR CO LTD
- Filing Date
- 2024-12-10
- Publication Date
- 2026-07-17
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Figure CN119613620B_ABST
Abstract
本申请涉及医学介入治疗材料的技术领域，具体公开了一种透明质酸钠栓塞微球的制备方法及制得的栓塞微球。一种透明质酸钠栓塞微球的制备方法包括：S1、向透明质酸钠水溶液中加入甲基丙烯酸酐、N,N‑二甲基甲酰胺、氢氧化钠，反应，再加入氯化钠，反应后，加入无水乙醇，沉淀，过滤去除滤液，清洗、干燥；S2、以甲基丙烯酰化透明质酸钠、带负电荷单体、引发剂、水的混合物水相；以油溶性液体、分散剂的混合物为油相；在氮气保护下，经反向悬浮聚合得到。本申请的一种透明质酸钠栓塞微球的制备方法，以甲基丙烯酰化透明质酸钠与带负电荷单体发生共聚引入带负电荷基团，使得微球有效负载化疗药物，且压缩弹性高。
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