Method for preparing micro-nanoparticles in decoction liquid of traditional chinese medicine decoction pieces

The freeze-thaw method was used to prepare micro- and nano-particles from the decoction of traditional Chinese medicine, which solved the problem of particle morphology diversity in the decoction of traditional Chinese medicine and achieved low-cost, highly biocompatible micro- and nano-particle preparation suitable for drug therapy.

CN119656039BActive Publication Date: 2026-07-03THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
Filing Date
2023-09-20
Publication Date
2026-07-03

AI Technical Summary

Technical Problem

There is no existing technology for preparing micro/nano particles from decoctions of traditional Chinese medicine, and traditional methods have difficulty synthesizing large-scale particles with diverse morphologies.

Method used

Micro- and nano-particles were prepared from the decoction of traditional Chinese medicine using a freeze-thaw method. The components in the supernatant of the decoction were aggregated to form micro- and nano-particles with various specific morphologies through freezing and thawing processes. The morphology of the particles was adjusted by modifying agents such as PEG 400, PEG 3000 or gelatin, and pure particles were obtained by centrifugation and washing steps.

Benefits of technology

Uniform and diverse micro/nanoparticles were prepared at low cost, with good biocompatibility, making them suitable for drug therapy and showing broad application prospects.

✦ Generated by Eureka AI based on patent content.

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Abstract

This invention relates to micro / nano materials, specifically to a method for preparing micro / nanoparticles from a decoction of traditional Chinese medicine (TCM) herbs. The method includes: providing a TCM decoction, obtaining a supernatant, freezing the supernatant at -80°C to -20°C for 12-24 hours; then thawing and collecting the micro / nanoparticles. This invention newly discovers the significant role of freeze-thaw interaction in the preparation of TCM micro / nanoparticles. The supernatant from the decoction of TCM herbs can produce micro / nanoparticles with various morphologies through freeze-thaw interaction, and the morphology can be controlled through process parameters. These uniform, morphologically diverse particles will have wide applications in pharmaceuticals, drug delivery, and tracer applications, and are also of great significance for research on the mechanisms of action of TCM.
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