一种环形RNA及其突变体和相关应用

By optimizing the nucleotide sequence of the circular RNA hsa_circ_0069982, its binding ability to hnRNP M was enhanced, solving the problems of tumor metastasis and chemotherapy resistance, and achieving effective targeted cancer therapy.

CN119662649BActive Publication Date: 2026-07-17SICHUAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SICHUAN UNIV
Filing Date
2024-12-19
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing technologies are unable to effectively target and inhibit hnRNP family proteins, making it difficult to address tumor metastasis and chemotherapy resistance.

Method used

Using circular RNA hsa_circ_0069982 and its mutants as aptamers, the binding ability to hnRNP M was enhanced and its function was inhibited by optimizing the nucleotide sequence of key regions.

Benefits of technology

It significantly inhibits tumor metastasis and chemotherapy resistance, and improves the efficacy of chemotherapy.

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Abstract

本发明公开了一种环形RNA及其突变体和相关应用，涉及医药领域。本发明首次公开了hsa_circ_0069982的新用途，其可以作为抗hnRNP家族蛋白的适配体RNA药物，增加其表达量能够显著抑制肿瘤转移并逆转肿瘤的化疗耐药；本发明发现，hsa_circ_0069982能直接与hnRNP M相互作用，依赖于hsa_circ_0069982关键区域，通过优化改造该区域的序列，能获得增强型突变体，序列如SEQ ID NO:2～6所示，表现出较野生型更强的hnRNP M的结合能力。经验证，hsa_circ_0069982及其增强型突变体有效抑制肿瘤转移及化疗耐药，为肿瘤治疗提供了新的途径和手段。
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