一种琥珀酸亚铁四水合物晶型、制备方法以及药物组合物
By controlling the molar ratio of sodium hydroxide to succinic acid and the pH value, the preparation process of ferrous succinate tetrahydrate was optimized, solving the problems of low yield and easy oxidation in the existing technology, and realizing the preparation and application of ferrous succinate tetrahydrate with high yield and high stability.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- JINLING PHARMA
- Filing Date
- 2023-09-22
- Publication Date
- 2026-07-17
AI Technical Summary
Existing methods for preparing ferrous succinate tetrahydrate have low yields and are easily oxidized, resulting in insufficient solubility and affecting iron absorption. Furthermore, the existing crystal forms exhibit instability during storage and clinical applications.
Ferrous succinate tetrahydrate was prepared under specific process conditions. By controlling the molar ratio of sodium hydroxide to succinic acid, controlling the pH value, and adding ferrous sulfate solution dropwise, the formation of basic salts was avoided, thereby improving reaction efficiency and purity and obtaining a stable crystal form.
It improves the yield and stability of ferrous succinate tetrahydrate, reduces the iron content, and improves flowability and compressibility, making it suitable for formulation molding.
Smart Images
Figure CN119684116B_ABST