Pyrazole hydrazide derivative containing diphenyl ether unit as well as preparation method and application of pyrazole hydrazide derivative
By developing pyrazole hydrazide derivatives containing diphenyl ether units, the problems of low specificity and great side effects in the treatment of cancer are solved, effective inhibition of a variety of cancer cells is achieved, and the candidate value of novel anti-tumor drugs is potentially valuable.
CN119707816AActive Publication Date: 2025-03-28JIANGSU OCEAN UNIV
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Patent Information
- Application Number
- CN202411890141.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-10
- Publication Date
- 2025-03-28
- Estimated Expiration
- 2044-12-10
AI Technical Summary
Technical Problem
Existing chemotherapy drugs have low specificity and serious side effects when treating cancer, making it difficult to develop new anti-tumor drugs with good efficacy and small toxic side effects.
Method used
A pyrazole hydrazide derivative containing diphenyl ether units was developed, the compound was prepared by a specific synthetic route and applied in antitumor cells.
Benefits of technology
This compound has a significant inhibitory effect on breast cancer cells, gastric cancer cells or pancreatic cancer cells, and the inhibition rate on pancreatic cancer cells reached 84.5% at a 10μM dose, which is better than the control drug fluorouracil.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention belongs to the field of medicines, and discloses a compound with a structure shown as a formula I. A preparation method of the compound comprises the following steps: substituting parachloronitrobenzene with phenol, and then carrying out reduction, diazotization, re-reduction, hydrochloric acid removal and hydrazide reaction to obtain a pyrazole hydrazide derivative containing a diphenyl ether unit, the pyrazole hydrazide derivative containing the diphenyl ether unit has an obvious inhibition effect on human pancreatic cancer cells, human breast cancer cells and human gastric cancer cells, and can be used as a potential novel antitumor candidate drug molecule. # imgabs0 #
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