一种单取向的强韧丝素蛋白支架及其制备方法
By employing directional cryoablation and chemical treatment, highly oriented silk fibroin scaffolds were prepared, solving the problem of decreased mechanical properties of regenerated silk fibroin and achieving high-strength and highly biocompatible silk fibroin scaffolds suitable for tissue engineering and regenerative medicine.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- ZHEJIANG UNIV
- Filing Date
- 2024-12-03
- Publication Date
- 2026-07-17
AI Technical Summary
Existing regenerated silk fibroin exhibits decreased mechanical properties during the preparation process, making it difficult to meet the high-strength application requirements of tissues such as muscles and tendons, especially when subjected to tensile stress in a single direction.
By controlling the micro-orientation structure of silk fibroin materials through directional freezing, and combining freeze-drying, humidification, mechanical compaction, and polar solvent-induced β-sheet crystallization, highly oriented and highly crystalline silk fibroin scaffolds were prepared.
A high-strength, highly biocompatible silk fibroin scaffold was fabricated, possessing excellent mechanical properties and stress transfer efficiency, making it suitable for tissue engineering and regenerative medicine.
Smart Images
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