一种卡培他滨新晶型M及其制备方法
A new capecitabine crystal form M was prepared by magnetic treatment and ultrasonic-induced crystallization, which solved the stability and solubility problems of the existing crystal form, realized the stable storage and safe use of capecitabine, and reduced the formulation processing cost.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- UNIV OF JINAN
- Filing Date
- 2025-02-25
- Publication Date
- 2026-07-17
AI Technical Summary
Existing capecitabine crystal forms suffer from poor stability, unsuitable solubility for sustained-release formulations, and environmentally unfriendly solvent systems, affecting drug formulation processing and medication safety.
A novel capecitabine crystal form M was prepared by magnetic treatment, ultrasonic-induced crystallization, and controlled cooling rate. A rare-earth permanent magnet was used to apply a magnetic field outside the reactor, and combined with an alcohol solvent and a specific ultrasonic frequency, the cooling rate was controlled within a specific range to allow crystal growth.
The prepared capecitabine new crystal form M has good stability, is easy to store and transport, has moderate solubility, and uses environmentally friendly solvents, which reduces the cost of formulation processing and improves the safety of medication.
Smart Images
Figure CN119735623B_ABST