一种制备α-氘代胺类化合物的合成技术

By using a reaction system of heavy water, thiols, and aromatic esters under light irradiation without a photocatalyst, α-deuterated amines were prepared, solving the problem of increased costs due to photocatalysts and achieving efficient and low-cost preparation of α-deuterated amines.

CN119751269BActive Publication Date: 2026-07-17ZHENGZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHENGZHOU UNIV
Filing Date
2024-12-26
Publication Date
2026-07-17

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Abstract

本发明涉及一类医药技术领域的可用于制备α‑氘代胺类化合物的合成方法，属于化学制药技术领域。具体涉及如式I所示的α‑氘代胺类化合物的合成方法。α‑氘代胺化合物的通式如式I所示。α‑氘代胺类化合物由相应的胺为底物，硫醇为催化剂，重水为氘源，芳香酸酯为添加剂，酯类为反应溶剂，在光照射下生成。这类化合物可用于药物开发或合成其它类型的氘代分子。
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