Preparation method of fluopyram
By using a two-step reaction method of amine ethyl trimethylsilane and 2-trifluoromethylbenzoyl chloride as raw materials, the existing fluopyram synthesis method has been solved, and the high efficiency and high purity synthesis of fluopyram is achieved, which is suitable for industrial promotion.
CN119751343AActive Publication Date: 2025-04-04JUNKAI (TIANJIN) CHEM CO LTD
Patent Information
- Application Number
- CN202411733107.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-29
- Publication Date
- 2025-04-04
- Estimated Expiration
- 2044-11-29
AI Technical Summary
Technical Problem
The existing fluopyram synthesis method has a long reaction route, low product quality, and some methods have problems that impurities are difficult to remove.
Method used
Fluopyramide is prepared by using amine ethyl trimethylsilane and 2-trifluoromethylbenzoyl chloride as raw materials. The reaction route is short, the yield is high, the product purity is high, and the solvent used can be reused.
Benefits of technology
It has achieved efficient synthesis of fluopyramide, high product purity, simplified reaction route, and is suitable for industrial promotion.
✦ Generated by Eureka AI based on patent content.
Smart Images
Figure CN119751343A_ABST
Abstract
The invention provides a preparation method of fluopyram, which comprises the following steps: step 1, adding aminoethyl trimethylsilane and 2-trifluoromethyl benzoyl chloride into a solvent, cooling, dropwise adding a first alkaline substance, obtaining an intermediate N-(trimethylsilyl ethyl)-2-trifluoromethyl benzamide after the 2-trifluoromethyl benzoyl chloride is completely reacted, adding a second alkaline substance into the intermediate N-(trimethylsilyl ethyl)-2-trifluoromethyl benzamide after the reaction is completed, and adding a second alkaline substance into the intermediate N-(trimethylsilyl ethyl)-2-trifluoromethyl benzoyl chloride after the reaction is completed to obtain an intermediate N-(trimethylsilyl ethyl)-2-trifluoromethyl benzoyl chloride; cooling the reaction liquid to-5 DEG C, stirring and filtering to obtain filtrate; 2, 2-halo-3-chloro-5-trifluoromethylpyridine, a second alkaline substance and a catalyst are added into the filtrate obtained in the step 1 for continuous reaction, after the intermediate N-(trimethylsilylethyl)-2-trifluoromethylbenzamide is completely reacted, part of the solvent is recovered under reduced pressure, cooling and filtering are conducted, and fluopyram is obtained. According to the preparation method, aminoethyl trimethylsilane and 2-trifluoromethyl benzoyl chloride are taken as raw materials, the 2-trifluoromethyl benzoyl chloride is prepared through two-step reaction, the reaction yield is high, the product purity is high, the used solvent can be recycled and reused, special dangerous reactions are not involved, and industrial popularization can be carried out.
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Citation Information
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