Antibacterial protective film for liquid medicine converter

Abstract

The present invention relates to the technical field of protective films, and specifically to an antibacterial protective film for a liquid medicine converter, which is made of the following raw materials in parts by weight: 50 to 65 parts of polyethersulfone, 25 to 30 parts of polylactic acid, 8 to 15 parts of pore formers, 8 to 13 parts of N-hydroxyethyl acrylamide, and 2 to 5 parts of poly(N-hydroxyethyl acrylamide). The preparation method is simple, the raw materials are cheap and easy to obtain, and the obtained antibacterial protective film has good stability and low adsorption, so that the liquid medicine in the transfer process can pass smoothly without the problem of membrane pore blockage and adsorption. At the same time, the film has a certain antibacterial effect on both bacteria and fungi, ensuring that the liquid medicine will not be contaminated during the conversion process, so that the original remaining medicine can continue to be used.

Description

Technical Field

[0001] The invention relates to the technical field of protective films, in particular to an antibacterial protective film for a liquid medicine converter. Background Art

[0002] As people's demand for medical services continues to increase, China's medical device market has been driven by rapid development. In recent years, the industry as a whole has entered a stage of rapid growth. When injecting liquid medicine, there is often residual liquid medicine in the syringe. To avoid waste, the remaining liquid medicine is continued to be injected. However, the repeated use of the same syringe will cause cross contamination. To solve this problem, the remaining liquid medicine in one syringe can be transferred to the syringe on the other side. This process requires a liquid medicine converter to complete.

[0003] The drug converter must ensure that the drug solution will not be contaminated during the transfer process so that the remaining drug can continue to be used. Therefore, an antibacterial protective film is required in the drug converter. When selecting the antibacterial protective film material, it is necessary to comprehensively consider factors such as biocompatibility and toxicological properties, microbial barriers, physical and chemical properties, and adaptability to the expected sterilization process. The obtained material must meet the requirements of bacterial isolation and non-toxicity, among which anti-pollution performance is particularly important for drug converters. Summary of the invention

[0004] In view of the problems described in the background technology, the present invention provides an antibacterial protective film for a liquid medicine converter, which has good stability and low adsorption, improves the utilization rate of liquid medicine, reduces liquid medicine waste, and reduces the cost of use, and is achieved through the following technical solutions:

[0005] The invention discloses an antibacterial protective film for a liquid medicine converter, which is made of the following raw materials in parts by weight: 50-65 parts of polyethersulfone, 25-30 parts of polylactic acid, 8-15 parts of a pore former, 8-13 parts of N-hydroxyethyl acrylamide, and 2-5 parts of poly(N-hydroxyethyl acrylamide).

[0006] Preferably, the pore former is selected from one or more of polyethylene glycol, polyethyleneimine, polyvinyl pyrrolidone and polysorbate.

[0007] A method for preparing an antibacterial protective film for a liquid medicine converter comprises the following steps:

[0008] Step (a): adding polyethersulfone, polylactic acid, N-hydroxyethyl acrylamide, poly(N-hydroxyethyl acrylamide) and solvent N,N-dimethylformamide into a stirrer in proportion, and rapidly stirring for 1 hour to obtain a membrane matrix;

[0009] Step (b): adding a pore-forming agent to the membrane matrix, placing the mixture in an autoclave at 120° C. for gelatinization, then taking the mixture out, adding a solvent N,N-dimethylformamide, and stirring the mixture at 50 to 75° C. for 10 to 12 hours to obtain a membrane casting solution;

[0010] Step (c): placing the casting solution in a vacuum drying oven for degassing;

[0011] Step (d): pouring the casting solution obtained in step (a) onto a flat glass, and scraping a uniform flat film with a coater;

[0012] Step (e): the obtained flat membrane is allowed to stand for 1 to 2 minutes and then immersed in deionized water for 0.5 to 1 hour, then taken out and transferred to pure water for another 10 to 12 hours;

[0013] Step (f): the antibacterial protective film after soaking is placed in an oven to dry, and after drying, is placed in a constant temperature and humidity chamber at 23° C. for equilibration for 12 hours to obtain the antibacterial protective film of the liquid medicine converter.

[0014] Preferably, the degassing condition in step (c) is to place it in a -0.05 MPa vacuum drying oven for degassing for 30 minutes.

[0015] Preferably, the coater thickness in step (d) is 200 μm.

[0016] Preferably, the drying condition in step (f) is drying at 60° C. for 5 hours.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] (1) The present invention provides an antibacterial protective film for a drug liquid converter. In the present invention, different antibacterial protective films are obtained by changing the quality of the formula materials and the process. During the preparation process, a pore-forming agent is added to make the prepared antibacterial protective film have good stability and low adsorption, so that the drug liquid can pass smoothly without the problem of membrane pore blockage and adsorption. At the same time, the film has a certain antibacterial effect on both bacteria and fungi, ensuring that the drug liquid will not be contaminated during the conversion process, so that the original remaining drug can continue to be used.

[0019] (2) The preparation method of the present invention is simple, and the raw materials are cheap and easily available, thus reducing the production cost of the enterprise. DETAILED DESCRIPTION

[0020] The following embodiments of the technical solution of the present invention are described in detail in conjunction with the embodiments. The following embodiments are only used to more clearly illustrate the technical solution of the present invention, and are therefore only used as examples, and cannot be used to limit the protection scope of the present invention.

[0021] It should be noted that the experimental methods used in the implementation examples are all conventional methods unless otherwise specified; the materials, reagents, etc. used, unless otherwise specified, can be obtained from commercial channels.

[0022] In the present invention, unless otherwise specified, all "parts" and percentages (%) refer to percentages by weight.

[0023] In the present invention, unless otherwise specified, the sum of all percentages in all compositions is 100%.

[0024] In the present invention, unless otherwise specified, the numerical range "a-b" represents an abbreviation of any real number combination between a-b, where a and b are real numbers. For example, the numerical range "0-5" means that all real numbers between "0-5" are listed in this document, and "0-5" is just an abbreviation of these numerical combinations.

[0025] In the present invention, unless otherwise specified, all embodiments and preferred embodiments mentioned herein can be combined with each other to form a new technical solution.

[0026] In the present invention, unless otherwise specified, all the steps mentioned herein may be performed sequentially or randomly, but are preferably performed sequentially; for example, the method includes steps (a) and (b), which means that the method may include steps (a) and (b) performed sequentially, or may include steps (b) and (a) performed sequentially; for example, the method may further include step (c), which means that step (c) may be added to the method in any order, for example, the method may include steps (a), (b) and (c), or may include steps (a), (c) and (b), or may include steps (c), (a) and (b), etc.

[0027] In the present invention, unless otherwise specified, the specific numerical values ​​and specific substances in the embodiments of the present invention may be combined with other features of the description part of the present invention; for example, if the specification mentions that the reaction temperature is 10-100°C, and the embodiment mentions that the reaction temperature is 20°C, then it can be considered that the present invention has specifically disclosed the range of 10-20°C, or the range of 20-100°C, and this range can be combined with other features of the description part to form a new technical solution.

[0028] Example 1

[0029] (1) adding 55 parts of polyethersulfone, 25 parts of polylactic acid, 8 parts of N-hydroxyethyl acrylamide, 2 parts of poly(N-hydroxyethyl acrylamide) and solvent N,N-dimethylformamide (DMF) into a stirrer and rapidly stirring for 1 hour to obtain a membrane matrix;

[0030] (2) adding 10 parts of polyethylene glycol to the membrane matrix, placing the mixture in an autoclave at 120° C. for gelatinization, then taking the mixture out and adding DMF, stirring the mixture at 50 to 75° C. for 10 to 12 hours to obtain a membrane casting solution;

[0031] (3) Degas the casting solution in a -0.05 MPa vacuum drying oven for 30 min;

[0032] (4) pouring the casting solution obtained above onto a flat glass and scraping a uniform flat film with a thickness of 200 μm using a coater;

[0033] (5) After the obtained flat membrane is allowed to stand for 1 to 2 minutes, it is immersed in deionized water for 0.5 to 1 hour, and then taken out and transferred to pure water for another 10 to 12 hours;

[0034] (6) The soaked antibacterial protective film is placed in an oven at 60° C. for drying for 5 hours, and then placed in a constant temperature and humidity chamber at 23° C. for equilibrium for 12 hours to obtain an antibacterial protective film for a liquid medicine converter.

[0035] Example 2

[0036] (1) adding 50 parts of polyethersulfone, 30 parts of polylactic acid, 10 parts of N-hydroxyethyl acrylamide, 2 parts of poly(N-hydroxyethyl acrylamide) and DMF into a blender and rapidly stirring for 1 hour to obtain a membrane matrix;

[0037] (2) adding 8 parts of polyethylene glycol to the membrane matrix, placing the mixture in an autoclave at 120° C. for gelatinization, then taking the mixture out and adding DMF, stirring the mixture at 50 to 75° C. for 10 to 12 hours to obtain a membrane casting solution;

[0038] (3) Degas the casting solution in a -0.05 MPa vacuum drying oven for 30 min;

[0039] (4) pouring the casting solution obtained above onto a flat glass and scraping a uniform flat film with a thickness of 200 μm using a coater;

[0040] (5) After the obtained flat membrane is allowed to stand for 1 to 2 minutes, it is immersed in deionized water for 0.5 to 1 hour, and then taken out and transferred to pure water for another 10 to 12 hours;

[0041] (6) The soaked antibacterial protective film is placed in an oven at 60° C. for drying for 5 hours, and then placed in a constant temperature and humidity chamber at 23° C. for equilibrium for 12 hours to obtain an antibacterial protective film for a liquid medicine converter.

[0042] Example 3

[0043] (1) adding 57 parts of polyethersulfone, 25 parts of polylactic acid, 8 parts of N-hydroxyethyl acrylamide, 2 parts of poly(N-hydroxyethyl acrylamide) and DMF into a blender and rapidly stirring for 1 hour to obtain a membrane matrix;

[0044] (2) adding 8 parts of polysorbate to the membrane matrix, placing the mixture in an autoclave at 120° C. for gelatinization, then taking the mixture out, adding DMF and stirring at 50-75° C. for 10-12 hours to obtain a membrane casting solution;

[0045] (3) Degas the casting solution in a -0.05 MPa vacuum drying oven for 30 min;

[0046] (4) pouring the casting solution obtained above onto a flat glass and scraping a uniform flat film with a thickness of 200 μm using a coater;

[0047] (5) After the obtained flat membrane is allowed to stand for 1 to 2 minutes, it is immersed in deionized water for 0.5 to 1 hour, and then taken out and transferred to pure water for another 10 to 12 hours;

[0048] (6) The soaked antibacterial protective film is placed in an oven at 60° C. for drying for 5 hours, and then placed in a constant temperature and humidity chamber at 23° C. for equilibrium for 12 hours to obtain an antibacterial protective film for a liquid medicine converter.

[0049] Example 4

[0050] (1) adding 55 parts of polyethersulfone, 25 parts of polylactic acid, 8 parts of N-hydroxyethyl acrylamide, 2 parts of poly(N-hydroxyethyl acrylamide) and DMF into a blender and rapidly stirring for 1 hour to obtain a membrane matrix;

[0051] (2) adding 10 parts of polyethyleneimine to the membrane matrix, placing the mixture in an autoclave at 120° C. for gelatinization, then taking the mixture out, adding DMF and stirring at 50 to 75° C. for 10 to 12 hours to obtain a membrane casting solution;

[0052] (3) Degas the casting solution in a -0.05 MPa vacuum drying oven for 30 min;

[0053] (4) pouring the casting solution obtained above onto a flat glass and scraping a uniform flat film with a thickness of 200 μm using a coater;

[0054] (5) After the obtained flat membrane is allowed to stand for 1 to 2 minutes, it is immersed in deionized water for 0.5 to 1 hour, and then taken out and transferred to pure water for another 10 to 12 hours;

[0055] (6) The soaked antibacterial protective film is placed in an oven at 60° C. for drying for 5 hours, and then placed in a constant temperature and humidity chamber at 23° C. for equilibrium for 12 hours to obtain an antibacterial protective film for a liquid medicine converter.

[0056] Example 5

[0057] (1) adding 51 parts of polyethersulfone, 28 parts of polylactic acid, 9 parts of N-hydroxyethyl acrylamide, 3 parts of poly(N-hydroxyethyl acrylamide) and DMF into a blender and rapidly stirring for 1 hour to obtain a membrane matrix;

[0058] (2) adding 9 parts of polysorbate to the membrane matrix, placing the mixture in an autoclave at 120° C. for gelatinization, then taking the mixture out, adding DMF and stirring at 50-75° C. for 10-12 hours to obtain a membrane casting solution;

[0059] (3) Degas the casting solution in a -0.05 MPa vacuum drying oven for 30 min;

[0060] (4) pouring the casting solution obtained above onto a flat glass and scraping a uniform flat film with a thickness of 200 μm using a coater;

[0061] (5) After the obtained flat membrane is allowed to stand for 1 to 2 minutes, it is immersed in deionized water for 0.5 to 1 hour, and then taken out and transferred to pure water for another 10 to 12 hours;

[0062] (6) The soaked antibacterial protective film is placed in an oven at 60° C. for drying for 5 hours, and then placed in a constant temperature and humidity chamber at 23° C. for equilibrium for 12 hours to obtain an antibacterial protective film for a liquid medicine converter.

[0063] Antibacterial testing

[0064] Example 6

[0065] The antibacterial protective films prepared in Examples 1 to 5 were cut into 1×1 cm pieces, sterilized, and set aside;

[0066] Bacterial culture: The second generation of Staphylococcus aureus [CMCC(B)26003] was selected. The frozen Staphylococcus aureus was thawed at room temperature, and then the Staphylococcus aureus was taken into TSB and cultured at 37℃ for 24 hours. The bacteria were centrifuged and diluted to 10% with 0.9% sterile sodium chloride solution. 7 cfu / ml, and a suspension of Staphylococcus aureus was obtained;

[0067] Transfer the sterilized sample to a sterile dish, take 5 drops of Staphylococcus aureus suspension and evenly drop them on the outer surface of the sample without contacting each other, and dry them at 26°C and 40% humidity for 10 hours;

[0068] The inner surface of the contaminated sample was completely spread on the surface of the nutrient agar medium and discarded after 5 seconds. The nutrient agar medium was cultured at 37°C for 24 hours, the bacterial growth was observed, and the number of surviving bacteria was recorded. The experimental results are shown in Table 1.

[0069] Table 1

[0070]

[0071] Example 7

[0072] The determination steps of Candida albicans refer to Example 6, and the experimental results are shown in Table 2.

[0073] Table 2

[0074]

[0075] From Table 1 and Table 2 above, it can be seen that the number of Staphylococcus aureus and Candida albicans passing through the antibacterial protective film is significantly reduced, from which it can be inferred that the antibacterial protective film prepared by the present invention has a certain antibacterial effect on both bacteria and fungi.

[0076] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein by equivalents. These modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present invention, and they should all be included in the scope of the claims and specification of the present invention.

Claims

1. A bacterial protection film for a liquid medicine converter, characterized in that: The invention is prepared from the following raw materials in parts by weight: 50-65 parts of polyethersulfone, 25-30 parts of polylactic acid, 8-15 parts of pore-forming agent, 8-13 parts of N-hydroxyethyl acrylamide and 2-5 parts of poly(N-hydroxyethyl acrylamide).

2. The antibacterial protective film for a liquid medicine converter according to claim 1, characterized in that: The pore former is selected from one or more of polyethylene glycol, polyethylene imine, polyvinyl pyrrolidone and polysorbate.

3. The method for preparing an antibacterial protective film for a liquid medicine converter according to claims 1 to 2, characterized in that: The following steps are involved: Step (a): adding polyethersulfone, polylactic acid, N-hydroxyethyl acrylamide, poly(N-hydroxyethyl acrylamide) and solvent N,N-dimethylformamide into a stirrer in proportion, and rapidly stirring for 1 hour to obtain a membrane matrix; Step (b): adding a pore-forming agent to the membrane matrix, placing the mixture in an autoclave at 120° C. for gelatinization, then taking the mixture out, adding a solvent N,N-dimethylformamide, and stirring the mixture at 50 to 75° C. for 10 to 12 hours to obtain a membrane casting solution; Step (c): placing the casting solution in a vacuum drying oven for degassing; Step (d): pouring the casting solution obtained in step (a) onto a flat glass, and scraping a uniform flat film with a coater; Step (e): the obtained flat membrane is allowed to stand for 1 to 2 minutes and then immersed in deionized water for 0.5 to 1 hour, then taken out and transferred to pure water for another 10 to 12 hours; Step (f): the antibacterial protective film after soaking is placed in an oven to dry, and after drying, is placed in a constant temperature and humidity chamber at 23° C. for equilibration for 12 hours to obtain the antibacterial protective film of the liquid medicine converter.

4. The method for preparing an antibacterial protective film for a liquid medicine converter according to claim 4, characterized in that: The degassing condition in step (c) is to place it in a -0.05MPa vacuum drying oven for degassing for 30 minutes.

5. The method for preparing an antibacterial protective film for a liquid medicine converter according to claim 4, characterized in that: The coating thickness of step (d) was 200 μm.

6. The method for preparing an antibacterial protective film for a liquid medicine converter according to claim 4, characterized in that: The drying condition in step (f) is drying at 60° C. for 5 hours.

7. A drug liquid converter antibacterial protective film, characterized in that: Prepared by the preparation method according to any one of claims 1 to 6.

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