A laboratory for radioactive animal feeding

Abstract

This invention relates to a laboratory for raising radioactive animals. The wall thickness is determined through a scientifically calculated shielding thickness formula to meet the laboratory's wall shielding protection requirements, significantly improving the shielding capability against high-intensity radiation while achieving optimal material configuration and reducing construction costs. The laboratory employs a ventilation system including louvered air vents, return air columns, and exhaust ducts. Combined with iodine adsorption devices or air filtration devices, it effectively controls the spread of radioactive contamination and improves air circulation efficiency. Furthermore, the seamless design of hand-laid magnesium oxide rock wool purification material on both the inner and outer sides of the reinforced concrete wall panels and PVC flooring enhances the structure's strength, durability, and ease of cleaning, further improving the laboratory's safety and maintenance convenience. The technical solution provided by this invention achieves efficient protection and contamination control in radioactive animal rearing laboratories and is applicable to various application scenarios in the field of radioactive research.

Description

Technical Field

[0001] This invention relates to the field of biological laboratory construction, and more particularly to a laboratory for raising radioactive animals. Background Technology

[0002] In recent years, with the rapid development of the radiopharmaceutical R&D industry chain, the application scope of radiopharmaceuticals has been continuously expanding, especially in the fields of tumor treatment and diagnosis, where their importance has become increasingly prominent. To support the development of this industry, my country released the "Medium- and Long-Term Development Plan for Medical Isotopes (2021-2035)" in 2021, further promoting the R&D of radiopharmaceuticals and their widespread application in clinical and scientific research. As innovative drugs enter the preclinical safety evaluation stage, the demand for radioactive animal experimental environments has increased significantly.

[0003] As a critical infrastructure in the safety evaluation of radiopharmaceuticals, radioactive animal housing facilities not only need to meet stringent requirements for radiation shielding and contamination protection, but also must ensure the health of laboratory animals and the reliability of the experimental environment. However, the number of facilities dedicated to radioactive animal housing in China is currently limited, and most lack standardized design and construction plans, resulting in high construction costs, inconsistent protection effectiveness, and potentially affecting the accuracy of experimental results.

[0004] Therefore, this paper proposes a scientific, reasonable, and cost-effective design for radioactive animal rearing rooms, addressing the existing problems in their design and construction. This is of great significance for improving laboratory safety, saving construction costs, and ensuring the smooth conduct of experiments.

[0005] In view of the above problems, this invention is proposed. Summary of the Invention

[0006] This invention discloses a laboratory for raising radioactive animals, aiming to solve the technical problems existing in the prior art.

[0007] This invention provides a method for constructing a laboratory for raising radioactive animals, comprising:

[0008] The experimental area is used for the breeding and experimental operations of radioactive animals.

[0009] The wall consists of a first wall panel, a second wall panel, and a third wall panel. The second wall panel is a single, square piece. The first and third wall panels are located on the inner and outer sides of the second wall panel, respectively. The thickness of the second wall panel is calculated using the following formula:

[0010]

[0011] In the formula:

[0012] x represents the shielding thickness, in millimeters (mm).

[0013] TVL is the thickness of a layer that is one-tenth the value of gamma rays, measured in millimeters (mm).

[0014] A is the maximum activity of a radioactive source used in a single animal, measured in megabecq (MBq).

[0015] Γ is the ambient dose equivalent rate constant at a distance of 1 m from the source, with units of μSv·m. 2 / MBq·h;

[0016] It is the dose rate control value for shielded external focus, in microsieverts per hour (μSv / h);

[0017] r is the distance between the reference point and the radiation source, in meters (m);

[0018] The ground is covered with PVC flooring. The PVC flooring rises at the connection point with the first and third wall panels and connects with the first and third wall panels.

[0019] The return air column system includes multiple return air columns and a main exhaust duct. The multiple return air columns are located inside the experimental area, while the main exhaust duct is located outside the experimental area. The multiple return air columns are connected to the main exhaust duct. The side walls of the multiple return air columns are equipped with louvered air outlet installation areas, and louvered air outlets are installed in the louvered air outlet installation areas.

[0020] As a preferred technical solution, the main exhaust duct is equipped with multiple exhaust sub-ducts, and multiple return air columns are connected to the multiple exhaust sub-ducts.

[0021] As a preferred technical solution, the number of multiple return air columns is the same as the number of exhaust air distribution channels, and the number of return air columns is 4.

[0022] As a preferred technical solution, four return air columns are respectively set in the four corners of the experimental area.

[0023] As a preferred technical solution, an iodine adsorption device or an air filtration device is installed at the end of the main exhaust duct.

[0024] As a preferred technical solution, the inner and outer bottom sides of the second wall panel are provided with lifting groove aluminum and aluminum floor groove, the lifting groove aluminum is set above the aluminum floor groove, and the first wall panel and the third wall panel are respectively set above the lifting groove aluminum.

[0025] As a preferred technical solution, both the first and third wall panels are made of handmade glass magnesium rock wool purification material.

[0026] As a preferred technical solution, an electric constant / variable air volume valve is installed at the confluence of multiple exhaust channels, and a sealed sampling port is installed at the front end of the electric constant air volume venturi valve.

[0027] As a preferred technical solution, the thickness of the second wall panel is 180-210mm; the thickness of the first and third wall panels is 50-100mm.

[0028] As a preferred technical solution, the bottom of the third wall panel is provided with a recessed area of ​​1.5-3mm × 7-9cm, and the size of the upward-facing area of ​​the PVC panel matches the recessed area.

[0029] The technical solution adopted in this invention can achieve at least one of the following beneficial effects:

[0030] 1. This invention uses a scientifically calculated shielding thickness formula to accurately determine the shielding protection requirements of laboratory walls. Using the one-tenth the value layer thickness (TVL) of gamma rays as the core parameter, and combining key indicators such as radioactive source activity, ambient dose equivalent rate constant, and control dose rate, the wall thickness design is optimized. This design effectively reduces the risk of leakage of high-intensity radiation into the laboratory, ensures the safety of the experimental environment, achieves optimal material configuration, and reduces construction costs.

[0031] 2. This invention achieves efficient internal air circulation and exhaust by setting up a ventilation system that connects the return air column and the exhaust air distribution channel. In particular, the rational arrangement of the louvered air vents on the side wall of the return air column and the application of an iodine adsorption device / air filter device at the end of the main exhaust air channel not only improves the air filtration and adsorption capacity for radioactive iodine, but also effectively controls the spread of radioactive contamination in the experimental area, providing a safer and cleaner environment for long-term experimental operations.

[0032] 3. This invention significantly improves the strength and ease of installation of the walls by laying handmade magnesium oxide rock wool purification material on both the inner and outer sides of the second wall panel (first and third wall panels), combined with the installation design of aluminum lifting channels and aluminum floor channels. Simultaneously, the seamless connection between the PVC floor and the wall avoids potential hazards of dust accumulation and radioactive contamination, making the floor and wall structures more durable and easier to clean. Through these integrated construction measures, the service life and maintenance convenience of the laboratory are significantly improved. Attached Figure Description

[0033] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the description of the embodiments will be briefly introduced below, forming part of the present invention. The illustrative embodiments of the present invention and their descriptions explain the present invention and do not constitute an improper limitation of the present invention. In the accompanying drawings:

[0034] Figure 1This is a front view of a laboratory for raising radioactive animals according to the present invention.

[0035] Figure 2 For the present invention Figure 1 A magnified structural diagram of A in the middle;

[0036] Figure 3 This is a top view of a laboratory for raising radioactive animals according to the present invention.

[0037] Explanation of reference numerals in the attached figures:

[0038] 1. Experimental area; 2. Ceiling; 3. Wall; 31. First wall panel; 32. Second wall panel; 33. Third wall panel; 4. Ground; 5. Aluminum lifting groove; 6. Aluminum floor groove; 7. Return air column system; 71. First return air column; 72. Second return air column; 73. Third return air column; 74. Fourth return air column; 8. Louvered air outlet. Detailed Implementation

[0039] To make the objectives, technical solutions, and advantages of this invention clearer, the technical solutions of this invention will be clearly and completely described below in conjunction with specific embodiments and corresponding drawings. In the description of this invention, it should be noted that the term "or" is generally used to include the meaning of "and / or," unless otherwise expressly indicated.

[0040] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or a magnetic connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal communication between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances. Furthermore, in the description of this application, the terms "first," "second," etc., are used only for distinguishing descriptions and should not be construed as indicating or implying relative importance.

[0041] Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0042] To address the problems existing in the prior art, embodiments of the present invention provide a laboratory for raising radioactive animals, such as... Figure 1-3As shown, the laboratory includes experimental area 1, ceiling 2, walls 3, and return air column system 7. Experimental area 1 is used for the breeding and experimental operation of radioactive animals, meeting the space and functional requirements of the experiment. Ceiling 2 and walls 3 serve as supporting and shielding structures to isolate radioactive materials and ensure the safety of the external environment of the laboratory. Return air column system 7 is used to exhaust the air inside the laboratory through the shortest path, reducing the radiation hazards to laboratory personnel during operation and maintaining the air quality inside the laboratory to meet standards.

[0043] like Figure 1 and Figure 3 As shown, wall 3 includes a first wall panel 31, a second wall panel 32, and a third wall panel 33. The second wall panel 32 is made of reinforced concrete and is formed by casting. Except for the reserved doorway, the second wall panel 32 is an integral square structure formed around the perimeter of the experimental area 1. Preferably, to ensure structural support and shielding effects, the thickness of the second wall panel 32 is calculated using the following formula:

[0044]

[0045] In the formula:

[0046] x represents the shielding thickness, in millimeters (mm).

[0047] TVL is the thickness of a layer that is one-tenth the value of gamma rays, measured in millimeters (mm).

[0048] A is the maximum activity of a radioactive source used in a single animal, measured in megabecq (MBq).

[0049] Γ is the ambient dose equivalent rate constant at a distance of 1 m from the source, with units of μSv·m. 2 / MBq·h;

[0050] It is the dose rate control value for shielded external focus, in microsieverts per hour (μSv / h);

[0051] r is the distance between the reference point and the radiation source, measured in meters (m).

[0052] More preferably, the thickness of the second wall panel 32 is 180-210mm. The first wall panel 31 and the third wall panel 33 are respectively disposed on the inner and outer sides of the second wall panel 32. Preferably, both the first wall panel 31 and the third wall panel 33 are made of handmade glass magnesium rock wool purification material to enhance the fire resistance, corrosion resistance, and moisture resistance of the wall 3, while improving the radiation protection effect and the temperature and humidity regulation capability of the indoor environment. The thickness of the first wall panel 31 and the third wall panel 33 is set to 50-100mm according to the building requirements. Preferably, in order to adapt to the ground connection requirements, the near-ground end of the first wall panel 31 and the third wall panel 33 is set to 48-98mm, that is, the thickness of the near-ground end of the first wall panel 31 and the third wall panel 33 is 1.5-3mm less than the thickness of the wall panel itself.

[0053] like Figure 1 and Figure 3 As shown, the return air column system 7 includes a first return air column 71, a second return air column 72, a third return air column 73, a fourth return air column 74, and a main exhaust duct (not shown in the figure). The first, second, third, and fourth return air columns 71, 72, 73, and 74 are located inside the first wall panel 31, respectively at the four corners of the experimental area 1, providing exhaust ducts for the experimental area 1. The main exhaust duct is located outside the experimental area 1 and is connected to the four return air columns. Two side walls of the first, second, third, and fourth return air columns 71, 72, 73, and 74 are connected to the first wall panel 31, and the other two side walls are each equipped with a hand-made magnesium oxide rock wool purification panel to provide support and protection for the return air columns. Louvered air vents 8 are installed on the first, second, third, and fourth return air columns 71, 72, 73, and 74 to allow airflow between the return air columns and the experimental area 1. The main exhaust duct located externally is divided into four exhaust sub-ducts. These four sub-ducts are connected to the first return air column 71, the second return air column 72, the third return air column 73, and the fourth return air column 74, respectively. At the junction of these four exhaust sub-ducts, an electric constant / variable air volume valve (not shown in the figure) is installed to precisely adjust the exhaust volume. A sealed sampling port is installed at the front end of the electric constant / variable air volume valve to take samples when the valve malfunctions and needs to be disassembled or repaired.

[0054] Through the above structural design, the laboratory is rationally laid out and functionally configured. Experimental area 1 is the core area for radioactive feeding and experimental operations. The roof slab 2 and walls 3 together serve as structural support and shielding structures. Wall 3 consists of three layers, with the second wall panel 32 located in the middle. It is integrally cast with reinforced concrete, forming a four-sided shielding structure around experimental area 1 to provide excellent radiation shielding and structural stability. The first wall panel 31 and the third wall panel 33 are respectively located inside and outside the second wall panel 32, using handmade magnesium oxide rock wool purification material, which not only improves the wall's durability but also enhances its resistance to radiation. The invention features fire resistance, corrosion resistance, and moisture resistance, and further optimizes radiation protection and indoor temperature and humidity regulation. Experimental area 1 is equipped with a first return air column 71, a second return air column 72, a third return air column 73, and a fourth return air column 74. An external main exhaust channel is provided, divided into four sub-exhaust channels, each connected to one of the four return air columns. Electric constant / variable air volume valves are installed on the sub-exhaust channels to precisely adjust the exhaust volume, thereby controlling the airflow balance and pollutant emissions within experimental area 1. Each return air column is equipped with a louvered vent 8 to facilitate airflow between the experimental area 1 and the return air column. This embodiment of the invention effectively isolates radioactive materials, provides a safe and stable experimental environment, and reduces radiation hazards and maintains air quality standards through a highly efficient air circulation and purification system, thus meeting the multiple needs of radioactive animal husbandry and experimental operations.

[0055] In some preferred embodiments, such as Figure 2 As shown, the system also includes a ground surface 4, which is entirely covered with a transparent PVC floor. Preferably, the ground surface 4 is leveled using self-leveling compound before the floor is laid. More preferably, the thickness of the transparent PVC floor is 1.5-3mm. The connections between the PVC floor and the first wall panel 31 and the third wall panel 33 are respectively designed with an upward-curving structure, which is arc-shaped and connected to the bottom of the third wall panel 33. To enhance the sealing effect, the upward-curving structure and the third wall panel 33 are sealed with silicone sealant.

[0056] In some preferred embodiments, the height of the upward structure of the PVC floor is 7-9cm, and the length of the near-ground ends of the first wall panel 31 and the third wall panel 33 is also set to 7-9cm. The thickness of the near-ground ends of the first wall panel 31 and the third wall panel 33 is 1.5-3mm less than the thickness of the wall panel. That is, a recessed area of ​​1.5-3mm × 7-9cm is provided at the connection between the first wall panel 31 and the third wall panel 33 and the PVC floor, which matches the size of the upward structure of the PVC floor and is distributed with the upward structure of the PVC floor.

[0057] In some preferred embodiments, an iodine adsorption device or an air filter device is installed at the end of the external exhaust duct for air purification.

[0058] In some preferred embodiments, such as Figure 2 As shown, the bottom of the first wall panel 31 and the third wall panel 33 near the ground 4 are also provided with connected lifting groove aluminum 5 and aluminum floor groove 6 to increase the support strength of the wall.

[0059] In some preferred embodiments, the bottom of the first return air column 71, the second return air column 72, the third return air column 73 and the fourth return air column 74 near the ground 4 are also provided with lifting groove aluminum 5 and aluminum ground groove 6 to increase the support strength of the side walls of the four return air columns.

[0060] This invention also provides a method for constructing a laboratory for raising radioactive animals, comprising:

[0061] Step S1: Based on the specific needs of the radioactive animal breeding laboratory, determine the construction requirements of the above-mentioned radioactive animal breeding laboratory, such as air exchange rate, pressure requirements, lighting, temperature, humidity and shielding protection, etc.

[0062] Step S2: Based on the shielding requirements, calculate the wall thickness of the laboratory using the following formula:

[0063]

[0064] In the formula:

[0065] x represents the shielding thickness, in millimeters (mm).

[0066] TVL is the thickness of a layer that is one-tenth the value of gamma rays, measured in millimeters (mm).

[0067] A is the maximum activity of a radioactive source used in a single animal, measured in megabecq (MBq).

[0068] Γ is the ambient dose equivalent rate constant at a distance of 1 m from the source, with units of μSv·m. 2 / MBq·h;

[0069] It is the dose rate control value for shielded external focus, in microsieverts per hour (μSv / h);

[0070] r is the distance between the reference point and the radiation source, in meters (m);

[0071] Step S3: Based on the calculation results of the above steps, after reserving the door opening position, the second wall panel 32 is formed into an integral square structure and the experimental area 1 through the casting process;

[0072] Step S4: Set the first return air column 71, the second return air column 72, the third return air column 73 and the fourth return air column 74 at the four corners of the above-mentioned square structure / experimental area 1, and connect the first return air column 71, the second return air column 72, the third return air column 73 and the fourth return air column 74 to the four exhaust sub-channels of the external exhaust main channel to form indoor and outdoor exhaust;

[0073] Step S5: Level the ground 4 with self-leveling compound, and install the lifting groove aluminum 5 and aluminum floor groove 6 on the inner and outer bottom of the second wall panel 32;

[0074] Step S6: Lay handmade glass magnesium rock wool purification panels on the inner and outer sides of the second wall panel 32 and on the side walls of the first return air column 71, the second return air column 72, the third return air column 73, and the fourth return air column 74; reserve louvered air outlet installation areas on the side walls of the first return air column 71, the second return air column 72, the third return air column 73, and the fourth return air column 74; form the first wall panel 31 and the third wall panel 33 on the inner and outer sides of the second wall panel 32 respectively, and lay the first wall panel 31 and the third wall panel 33 on the upper part of the lifting groove aluminum 5 on the inner and outer sides of the second wall panel 32;

[0075] Step S7: Lay a transparent PVC floor on the ground 4, and seal the upward structure of the PVC floor with the first wall panel 31 and the third wall panel 33 respectively using silicone sealant.

[0076] Step S8: Install louvered air vents in the reserved louvered air vent installation areas on the side walls of the first return air column 71, the second return air column 72, the third return air column 73, and the fourth return air column 74; install electric constant / variable air volume valves on the four exhaust sub-channels of the external exhaust main channel; and install iodine adsorption devices on the top of the first return air column 71, the second return air column 72, the third return air column 73, and the fourth return air column 74 respectively.

[0077] The embodiments of the present invention have been described above with reference to the accompanying drawings. However, the present invention is not limited to the specific embodiments described above. The specific embodiments described above are merely illustrative and not restrictive. Those skilled in the art can make many other forms under the guidance of the present invention without departing from the spirit and scope of the claims, and all of these forms are within the protection scope of the present invention.

Claims

1. A laboratory for radioactive animal feeding, characterized in that, include: The experimental area is used for the breeding and experimental operations of radioactive animals. The wall includes a first wall panel, a second wall panel, and a third wall panel. The second wall panel is integrally square. The first wall panel and the third wall panel are respectively located on the inner and outer sides of the second wall panel. The thickness of the second wall panel is calculated using the following formula: In the formula: is the shield thickness in millimeters (mm); is the tenth-value layer thickness of gamma rays, in millimeters (mm); is the maximum activity of the radioactive source for a single animal, in megabecquerel (MBq); is the ambient dose equivalent rate constant at 1 m from the source in μSv·m 2 / MBq·h; is the shielding external concern dose rate control value in microsievert per hour (μSv / h); is the distance between the reference point and the radiation source in meters (m); The ground is covered with PVC flooring. The PVC flooring is raised at the connection point with the first wall panel and the third wall panel, and is connected to the first wall panel and the third wall panel. The bottom of the third wall panel is provided with a recessed area of ​​1.5-3mm × 7-9cm, and the size of the raised area of ​​the PVC flooring matches the recessed area. A return air column system includes multiple return air columns and a main exhaust duct. The multiple return air columns are located within the experimental area, and the main exhaust duct is located outside the experimental area. The multiple return air columns are connected to the main exhaust duct. Each of the multiple return air columns has a louvered vent mounting area on its side wall, and louvered vents are installed in each louvered vent mounting area. The main exhaust duct has multiple exhaust branch ducts, and the multiple return air columns are connected to the multiple exhaust branch ducts. The number of multiple return air columns is equal to the number of exhaust branch ducts. The number of exhaust channels is the same, and the number of return air columns is 4. The 4 return air columns are respectively set in the four corners of the experimental area. The two side walls of the 4 return air columns are connected to the first wall panel, and the bottom of the 4 return air columns near the ground is provided with lifting groove aluminum and aluminum floor groove. An electric constant / variable air volume valve is installed at the confluence of the multiple exhaust channels, and a sealed sampling port is installed at the front end of the electric constant / variable air volume valve. An iodine adsorption device or an air filter device is installed at the end of the main exhaust channel.

2. The laboratory according to claim 1, characterized in that, The inner and outer bottom sides of the second wall panel are provided with lifting groove aluminum and aluminum floor groove, the lifting groove aluminum is provided above the aluminum floor groove, and the first wall panel and the third wall panel are respectively provided above the lifting groove aluminum.

3. The laboratory according to claim 2, characterized in that, Both the first wall panel and the third wall panel are made of handmade glass magnesium rock wool purification material.

4. Laboratory according to any one of claims 1 to 3, characterized in that The thickness of the second wall panel is 180-210mm; the thickness of the first wall panel and the third wall panel is 50-100mm.

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