一种改善复溶性注射用左旋聚乳酸微球填充剂及其制备方法
By forming a supramolecular structure through the self-assembly of cyclodextrin and polylactic acid (PLA), the distribution of functional groups on the surface of the microspheres is changed, which solves the problems of poor resolubility and long resolubility of PLA microsphere fillers and achieves uniform dispersion and stable suspension of microspheres in the aqueous phase.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- BEIJING JINGYU YIMEI BIOTECHNOLOGY CO LTD
- Filing Date
- 2025-01-09
- Publication Date
- 2026-07-17
AI Technical Summary
Existing polylactic acid microsphere fillers exhibit poor dispersibility and long reconstitution time after freeze-drying, making it difficult to achieve uniform and stable dispersion in the aqueous phase.
A supramolecular structure material was formed by the self-assembly of cyclodextrin and polylactic acid (PLA). The arrangement of sodium carboxymethyl cellulose on the surface of the microspheres was changed. PLA composite microspheres were prepared by solvent evaporation method, which promoted the rapid penetration of water molecules and prevented the microspheres from becoming sticky and the particles from settling.
This method achieves uniform dispersion and stable suspension of L-polylactic acid microspheres in the aqueous phase, shortens the resolution time, and avoids microsphere adhesion and sedimentation.