A semi-closed negative pressure prosthesis for jaw bone defects

Abstract

A semi-closed negative pressure prosthesis for jawbone defects includes a substrate and a closed shell. The substrate is a 3D-printed titanium alloy mesh structure with both ends that fit snugly against the bone fracture ends. A negative pressure suction tube is embedded inwardly on the surface of the closed shell, and the outer opening of the negative pressure suction tube is used to seal the suction tube of a negative pressure suction device. This invention addresses jawbone defects where the periosteum is no longer present. The 3D-printed titanium alloy prosthesis fits snugly against the bone fracture ends at both ends, and the outer surface is closed, thus ensuring a negative pressure environment within the prosthesis even without the periosteum. The interior features a trabecular mesh structure, with a negative pressure suction tube at its lower end connecting to the suction tube of a negative pressure suction device for intermittent negative pressure suction (15-30 minutes / hour), promoting the growth and differentiation of local osteoblasts and facilitating rapid osteogenic repair within the prosthesis.

Description

Technical Field

[0001] This invention belongs to the clinical field of oral and maxillofacial surgery, specifically relating to a semi-closed negative pressure prosthesis for jawbone defects. Background Technology

[0002] Jawbone defects caused by factors such as trauma, tumors, and infections not only affect patients' normal physiological functions but also cause facial deformities, impacting their chewing, swallowing, and speech abilities, and severely affecting their mental health. Jawbone repair and reconstruction has long been a major clinical challenge. Currently, while methods such as autologous bone grafting, allogeneic bone grafting, distraction osteogenesis, and artificial replacement materials are used clinically, their application remains significantly limited due to surgical complexity, limited material sources, and the risk of rejection.

[0003] Currently, negative pressure drainage has been studied in clinical treatment. The principle behind negative pressure drainage is that negative pressure can accelerate the transformation of highly proliferating active epithelium and bone remodeling at the capsule-bone interface towards the cavity, thereby greatly shortening the treatment course. Furthermore, the negative pressure environment isolates the oral cavity from its bacterial environment, significantly reducing the chance of infection. However, in clinical applications of jawbone defect repair, negative pressure suction devices are required for drainage of the surgical area. Currently, there are no jawbone implants or prostheses that can be directly connected to external negative pressure drainage. Summary of the Invention

[0004] To address the above technical problems, this invention provides a negative pressure drainage prosthesis for jawbone defects.

[0005] The technical solution of the present invention is as follows:

[0006] A semi-closed negative pressure prosthesis for jawbone defects is characterized by comprising a matrix and a closed shell. The matrix is ​​a titanium alloy mesh structure formed by 3D printing, with both ends conforming to the bone fracture ends. A negative pressure suction tube is embedded inward on the surface of the closed shell, and the outer opening of the negative pressure suction tube is used to seal the suction tube of the negative pressure suction device.

[0007] Preferably, the mesh structure is a bone-like trabecular structure.

[0008] Preferably, the material of the enclosed shell is titanium alloy.

[0009] Preferably, the thickness of the enclosed shell is in the range of 0.3-3mm, and the diameter of the tube opening is 10-20mm.

[0010] More preferably, the thickness of the enclosed shell is 1 mm, and the diameter of the tube opening is 15 mm.

[0011] Preferably, the negative pressure suction base tube includes an inner tube and an outer tube, and the gap between the two is used to reserve the access of an external negative pressure drainage tube.

[0012] Preferably, the length of the negative pressure suction base tube is 10-30 mm.

[0013] More preferably, the length of the negative pressure suction base tube is 20 mm.

[0014] Preferably, the applied negative pressure is 125-450 mmHg, and intermittent negative pressure suction is performed for 15-30 minutes per hour.

[0015] The beneficial effects of this invention are as follows:

[0016] In recent years, additive manufacturing technology has gradually emerged in the field of bone defect repair, becoming a popular research and application area. Compared with traditional subtractive manufacturing technology, additive manufacturing has unique advantages. It can not only produce prostheses that perfectly match the shape of the mandible, but also precisely control the internal structure of the prosthesis, thereby producing prostheses that meet both morphological requirements and promote bone function repair.

[0017] This invention utilizes additive manufacturing technology to obtain a prosthesis matrix that conforms to the shape of the missing jawbone through 3D printing technology, and designs two types of prostheses that can be used with a negative pressure suction device for negative pressure assisted treatment, depending on whether the periosteum is present.

[0018] Specifically, this invention addresses jawbone defects where the periosteum is no longer present. A titanium alloy prosthesis is manufactured using 3D printing. The prosthesis is tightly fitted to the bone fracture ends at both ends, with a sealed outer surface. This ensures a negative pressure environment within the prosthesis even without the periosteum. The interior features a trabecular mesh structure, and a negative pressure suction tube at its lower end connects to the suction tube of a negative pressure suction device for intermittent negative pressure suction (15-30 minutes / hour). This promotes the growth and differentiation of local osteoblasts, facilitating rapid osteogenic repair within the prosthesis.

[0019] Experiments have shown that in vitro low-intensity intermittent negative pressure can successfully induce MSCs to differentiate into osteoblasts. Furthermore, the main cause of bone resorption in jawbone cysts is the secretion of cyst fluid by the cyst wall tissue, which increases the pressure within the cyst cavity, compressing and causing surrounding bone resorption. Similarly, using a negative pressure generating device to create negative pressure stress within the cyst cavity has a stronger promoting effect on new bone formation and remodeling at the prosthesis-bone interface, thus promoting new bone formation. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the overall structure of the jawbone after repair in Example 1;

[0021] Figure 2This is a schematic diagram of the structure near the negative pressure suction base tube and its connection part in Example 2;

[0022] The labels in the diagram are listed below:

[0023] 1-Matrix, 2-Closed shell, 3-Bone fracture end, 4-Tube opening, 5-Negative pressure suction base tube, 6-Gap. Detailed Implementation

[0024] To better understand the present invention, specific descriptions are provided below through embodiments. It should be noted that the following embodiments are for further illustration only and should not be construed as limiting the scope of protection of the present invention. Non-essential improvements and adjustments made by those skilled in the art based on the above description of the present invention still fall within the scope of protection of the present invention.

[0025] Example 1

[0026] This example illustrates a case of jawbone defects and periosteal absence, such as... Figure 1 As shown, a negative pressure prosthesis for complete jawbone loss in this embodiment includes a base 1 and a closed shell 2. The base 1 is a 3D-printed titanium alloy mesh structure with simulated bone trabeculae, and its two ends are closely fitted and fixed to the bone fracture ends 3. A titanium alloy negative pressure suction tube 5 is embedded inward on the lower surface of the closed shell 2. The outer port 4 of the negative pressure suction tube 5 is used to seal the suction tube connected to the negative pressure suction device.

[0027] The thickness of the enclosed shell is in the range of 0.3-3mm, the diameter of the tube opening is 10-20mm, and the length of the negative pressure suction base tube is 10-30mm. In this embodiment, the thickness of the enclosed shell is preferably 1mm, the diameter of the tube opening is 15mm, and the length of the negative pressure suction base tube is 20mm.

[0028] The applied negative pressure is 125-450 mmHg, and the pressure is adjusted according to the time and condition, with intermittent negative pressure suction for 15-30 minutes per hour.

[0029] The presence of the sealed outer shell 2 ensures the continuity of negative pressure inside the body after the negative pressure suction base tube is connected to the negative pressure suction device and the negative pressure is turned on. At the same time, the negative pressure suction base tube 5 itself can also be used as a drainage tube for draining tissue fluid.

[0030] Experiments have shown that the bone formation rate is increased by more than 30% compared to existing technologies, and the amount of bone formed is increased by more than 50%.

[0031] Example 2

[0032] like Figure 2As shown, the difference between this embodiment and embodiment 1 is that the negative pressure suction base tube 5 includes an inner tube and an outer tube, and the gap 6 between the two is used to reserve the access of the external negative pressure drainage tube, which can better drain tissue fluid.

[0033] The above description is merely a preferred embodiment of the present invention and is not intended to limit the invention in any other way. Any person skilled in the art may make changes or equivalent modifications to the above-disclosed technical content. However, any simple modifications, equivalent changes, and alterations made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the protection scope of the present invention.

Claims

1. A semi-closed negative pressure prosthesis for jawbone defects, characterized in that... It includes a base and a closed shell. The base is a titanium alloy mesh structure formed by 3D printing, and its two ends can be fitted to the bone fracture ends. The mesh structure is a bone trabecular structure. The closed shell is made of titanium alloy. A negative pressure suction tube is embedded inward on the surface of the closed shell. The outer opening of the negative pressure suction tube is used to seal the suction tube of the negative pressure suction device.

2. The restoration according to claim 1, characterized in that... The thickness of the enclosed shell is in the range of 0.3-3mm, and the diameter of the tube opening is 10-20mm.

3. The restoration according to claim 2, characterized in that... The thickness of the enclosed shell is 1 mm, and the diameter of the pipe opening is 15 mm.

4. The restoration according to claim 1, characterized in that... The negative pressure suction base tube includes an inner tube and an outer tube, with the gap between them reserved for the access of an external negative pressure drainage tube.

5. The restoration according to claim 1, characterized in that... The length of the negative pressure suction base tube is 10-30mm.

6. The restoration according to claim 5, characterized in that... The length of the negative pressure suction base tube is 20mm.

7. The restoration according to claim 1, characterized in that... The applied negative pressure is 125-450 mmHg, and intermittent negative pressure suction is performed for 15-30 minutes per hour.

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