Novel AIE photo-thermal agent and preparation method and application thereof

Abstract

The invention discloses a novel AIE photo-thermal agent and a preparation method and application thereof. The structural formula of the AIE photo-thermal agent is shown in the specification, and the AIE photo-thermal agent is excellent in luminescence performance and photo-thermal conversion performance and can be used for preparing tumor diagnosis reagents or tumor treatment drugs. The bionic nanoparticles loaded with the AIE photo-thermal agent and the STING agonist prepared by the invention can realize efficient delivery of drugs to tumor tissues, target tracing is performed on tumors based on the multi-mode imaging capability of AIE molecules, STING pathway activation of tumor cells ICD and DC cells can be enhanced through the photo-thermal effect of the bionic nanoparticles, anti-tumor immunotherapy is enhanced, and finally, far-end tumor growth is inhibited, so that the bionic nanoparticles loaded with the AIE photo-thermal agent and the STING agonist have good application prospects. And tumor recurrence and remetastasis. The material is simple in preparation process, low in cost and suitable for large-scale production and clinical medical application. # imgabs0 #

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