A kinesiology patch with massage particles and its preparation method

Abstract

This invention discloses a kinesiology patch with massage particles and its preparation method. The invention relates to the field of kinesiology patch technology. From top to bottom, it comprises a patch layer, an adhesive layer, a particle attachment layer, and a release layer. The particle attachment layer has a plurality of massage particles disposed on one side opposite the release layer. This kinesiology patch with massage particles and its preparation method, through the inclusion of massage particles, can decompose hyaluronic acid between cells, increase drug permeability, and allow the drugs contained in the patch layer to be better absorbed by the skin; simultaneously, it can delay drug release, thereby prolonging the drug's action time and maintaining a local effective drug concentration; it provides a basis for cell adhesion and proliferation, which helps repair and regenerate damaged muscle tissue; the massage particles have antibacterial and wound-healing effects, preventing skin infections that may occur during patch use, and facilitating the recovery of muscle injuries; it improves the patch's adhesion effect while reducing skin irritation.

Description

Technical Field

[0001] This invention relates to the field of kinesiology tape technology, specifically to a kinesiology tape with massage particles and its preparation method. Background Technology

[0002] Kinesiology tape can be used to relieve muscle pain caused by overuse of certain muscles or sports injuries, and to accelerate muscle recovery. In addition, the tape can provide a lifting effect to the skin to improve blood circulation, thereby reducing muscle swelling and inflammation. Furthermore, it can reduce muscle soreness by reducing the burden of muscle contraction.

[0003] Chinese Patent Publication No. CN221384040U discloses a kinesiology patch, specifically relating to the field of sports medicine technology. It includes an elastic patch body comprising two anchor points and a treatment section. The treatment section is fixedly connected to the two anchor points at both ends. The width of the treatment section is greater than the width of the anchor points. The contour lines of the ends of the treatment section not connected to the anchor points are a first arc line and a second arc line, respectively. Both the first and second arc lines are convex arc lines. This invention can better conform to the human body structure, is convenient and easy to use, and further promotes the clinical application of kinesiology patches. However, the existing technical solutions described above have the following drawbacks: the prepared kinesiology patch has poor antibacterial properties during use. Therefore, this invention provides a kinesiology patch with massage particles and its preparation method to solve the aforementioned problems. Summary of the Invention

[0004] To address the shortcomings of existing technologies, this invention provides a kinesiology patch with massage particles and its preparation method, thus solving the problems mentioned in the background section.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a kinesiology patch with massage particles, comprising, from top to bottom, a patch layer, an adhesive layer, a particle attachment layer, and a release layer. The particle attachment layer has a plurality of massage particles on one side relative to the release layer. The release layer has a plurality of vent holes, through which the massage particles pass. The release layer is adhesively attached to the surface of the particle attachment layer. The adhesive layer is coated on the surface of the patch layer, and during packaging, release paper is attached to the other side, separating the patch layer from the particle attachment layer and the release layer. The same package contains a particle attachment layer with massage particles of different sizes and specifications.

[0006] Preferably, the massage particles are made of gel material, and massage particles of different sizes are distributed in three forms on the same particle attachment layer: the same size, the same size, and a mixture of sizes.

[0007] Preferably, the specific preparation process of the massage granules is as follows:

[0008] S1. Mix 1.5-2.5g of hyaluronidase with 120mL of deionized water, and add 0.5g of vitamin C as an antioxidant to prevent the enzyme from being deactivated in subsequent steps; after stirring evenly, preheat in a 37°C constant temperature water bath for 15 minutes.

[0009] S2. Add 1.5-2g of sodium periodate to the above solution and stir at 200rpm for 3 hours under completely dark conditions. After the reaction is complete, add 5mL of 10% sodium thiosulfate solution to neutralize the remaining sodium periodate and prevent it from interfering with subsequent steps.

[0010] S3. Add 4-5 mL of ethylene glycol and 0.2 g of ethylenediaminetetraacetic acid to chelate the metal ions present and prevent them from affecting the gel properties. Continue stirring for 60 minutes.

[0011] S4. Place the reaction solution in deionized water and dialyze it using a dialysis bag with a molecular weight cutoff of 10 kDa. Extend the dialysis time to 24 hours to ensure that small molecule impurities are fully removed, and then freeze-dry it.

[0012] S5. Add 1-1.2g of modified hydroxyapatite and 0.8-1.2g of modified chitosan to the dried hyaluronidase-ethylene glycol mixture, and sonicate for 30 minutes until completely dissolved; then continue stirring for 30 minutes under ultrasonic stirring to form a uniform gel.

[0013] S6. Inject the gel into the mold and use a freeze-thaw cycle to enhance the strength and stability of the gel. The freeze-thaw cycle is to first freeze to -20°C, keep it for 2 hours, and then thaw it to room temperature, repeating this process 3 times. Finally, cut and shape the gel as needed to obtain the final massage particles.

[0014] Preferably, in step S5, the modified hydroxyapatite is prepared by mixing Tris-hydrochloric acid buffer with anhydrous ethanol, adding hydroxyapatite, sonicating for 35 minutes, then adding polydopamine solution, stirring in the dark for 24 hours, and finally freeze-drying to obtain modified hydroxyapatite.

[0015] Preferably, in the preparation process of the modified hydroxyapatite, the amount of each component added is: 90-100 mL of Tris-hydrochloric acid buffer, 10-20 mL of ethanol, 2-3.5 g of hydroxyapatite, and 0.8-1.5 g of polydopamine, and the polydopamine solution is pre-dissolved in 10 mL of deionized water with a concentration of 10 mg / mL.

[0016] Preferably, in step S5, the modified chitosan is prepared as follows: chitosan is dissolved in acetic acid solution, 20% hydrochloric acid solution is added dropwise, and deoxygenation is performed under a nitrogen atmosphere for 20 minutes. Then gallic acid is added, and solution one is obtained after complete dissolution. 1-ethyl-(3-dimethylaminopropyl)carbodiimide and N-hydroxysuccinimide are dissolved in deionized water to obtain solution two. Under a nitrogen atmosphere, solution one and solution two are mixed, dialyzed for 24 hours using a dialysis bag with a molecular weight cutoff of 3.5 kDa, and then freeze-dried to obtain modified chitosan.

[0017] Preferably, in the preparation process of the modified chitosan, the addition amounts of each component are as follows: chitosan 2.5-5g; acetic acid solution 4-7ml, with a concentration of 2%; deionized water 75-100mL; hydrochloric acid solution 4-6mL, with a concentration of 20%; gallic acid 3.5-6g; 1-ethyl-(3-dimethylaminopropyl)carbodiimide 2.8-4.2g; N-hydroxysuccinimide 1.6-2.5g.

[0018] The present invention also discloses a method for preparing a kinesiology patch with massage particles. The specific preparation method is as follows: the patch layer and the particle attachment layer are bonded together by an adhesive layer to obtain a kinesiology patch with massage particles.

[0019] This invention provides a kinesiology patch with massage particles and its preparation method. Compared with the prior art, it has the following beneficial effects: The kinesiology patch with massage particles and its preparation method, through the inclusion of massage particles, can decompose hyaluronic acid between cells, increase drug permeability, and allow the drugs contained in the patch layer to be better absorbed by the skin. Furthermore, different sizes of massage particles can achieve different massage effects to meet the different needs of users. Simultaneously, it can delay drug release, thereby prolonging the drug's action time and maintaining a local effective drug concentration; it provides a basis for cell adhesion and proliferation, which helps repair and regenerate damaged muscle tissue; the massage particles have antibacterial and wound-healing effects, preventing skin infections that may occur during patch use and facilitating the recovery of muscle damage; it improves the patch's adhesion while reducing skin irritation. Attached Figure Description

[0020] Figure 1 Comparison chart of Staphylococcus aureus metabolic activity test provided by the present invention;

[0021] Figure 2 This is a comparison chart of Escherichia coli metabolic activity tests provided by the present invention;

[0022] Figure 3 This is an exploded view of the kinesiology patch with large-particle massage particles of the present invention.

[0023] Figure 4This is an exploded view of the kinesiology patch of the small-particle massage particles of the present invention.

[0024] Figure 5 This is an exploded view of the kinesiology patch of the massage particles of the present invention, which is a mixture of large and small particles.

[0025] In the diagram, 1-attachment layer, 2-adhesive layer, 3-particle attachment layer, 4-isolation layer, 5-massage particles, 6-release paper. Detailed Implementation

[0026] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0027] See Figures 1-5 The present invention provides the following three technical solutions:

[0028] Example 1

[0029] A kinesiology patch with massage particles includes, from top to bottom, a patch layer 1, an adhesive layer 2, a particle attachment layer 3, and a release layer 4. The particle attachment layer 3 has a plurality of massage particles 5 on one side opposite to the release layer 4. The release layer 4 has a plurality of vent holes through which the massage particles 5 pass. The release layer 4 is bonded to the surface of the particle attachment layer 3. The adhesive layer 2 is coated on the surface of the patch layer 1. During packaging, release paper 6 is attached to the other side to separate the patch layer 1 from the particle attachment layer 3 and the release layer 4. The same package contains a particle attachment layer 3 with massage particles 5 of different sizes.

[0030] Among them, the massage particles 5 are made of gel material, and massage particles 5 of different sizes are distributed in three forms on the same particle attachment layer 3: the same size, the same size, and a mixture of sizes. The specific preparation process is as follows:

[0031] (1) Preparation of modified hydroxyapatite: Mix 90 mL of Tris-hydrochloric acid buffer with 10 mL of anhydrous ethanol, add 2 g of hydroxyapatite, sonicate for 35 minutes, then add 0.8 g of polydopamine solution 10 mg / mL, stir in the dark for 24 hours, and finally freeze dry to obtain modified hydroxyapatite.

[0032] (2) Preparation of modified chitosan: 2.5g of chitosan was dissolved in 4ml of 2% acetic acid solution, and 4mL of 20% hydrochloric acid solution was added dropwise. The mixture was deoxygenated under a nitrogen atmosphere for 20 minutes, and then 3.5g of gallic acid was added. After complete dissolution, solution one was obtained. 2.8g of 1-ethyl-(3-dimethylaminopropyl)carbodiimide and 1.6g of N-hydroxysuccinimide were dissolved in deionized water to obtain solution two. Solution one and solution two were mixed under a nitrogen atmosphere and dialyzed for 24 hours using a dialysis bag with a molecular weight cutoff of 3.5kDa. The mixture was then freeze-dried to obtain modified chitosan.

[0033] (3) Preparation of massage granules 5: Mix 1g of hyaluronidase with 120mL of deionized water, and add 0.5g of vitamin C as an antioxidant to prevent enzyme inactivation in subsequent steps; after stirring evenly, preheat in a 37℃ constant temperature water bath for 15 minutes; add 1g of sodium periodate to the above solution, and stir at 200rpm for 3 hours under completely dark conditions using a magnetic stirrer; after the reaction is complete, add 5mL of 10% sodium thiosulfate solution to neutralize the remaining sodium periodate and prevent it from interfering with subsequent steps; add 4mL of ethylene glycol, and simultaneously add 0.2g of ethylenediaminetetraacetic acid to chelate existing metal ions and prevent them from affecting gel performance, and continue stirring for 60 minutes; then add the reverse... The solution was placed in deionized water and dialyzed using a dialysis bag with a molecular weight cutoff of 10 kDa. The dialysis time was extended to 24 hours to ensure thorough removal of small molecule impurities, followed by freeze-drying. 1 g of modified hydroxyapatite and 1.2 g of modified chitosan were added to the dried hyaluronidase-ethylene glycol mixture and ultrasonically stirred for 30 minutes until completely dissolved. Then, under ultrasonic stirring, stirring was continued for another 30 minutes to form a uniform gel. The gel was injected into a mold and subjected to a freeze-thaw cycle to enhance its strength and stability. The freeze-thaw cycle consisted of freezing to -20°C, holding for 2 hours, and then thawing to room temperature, repeated 3 times. Finally, the gel was cut and shaped as needed to obtain the final massage particles.

[0034] Example 2

[0035] A kinesiology patch with massage particles includes, from top to bottom, a patch layer 1, an adhesive layer 2, a particle attachment layer 3, and a release layer 4. The particle attachment layer 3 has a plurality of massage particles 5 on one side opposite to the release layer 4. The release layer 4 has a plurality of vent holes through which the massage particles 5 pass. The release layer 4 is bonded to the surface of the particle attachment layer 3. The adhesive layer 2 is coated on the surface of the patch layer 1. During packaging, release paper 6 is attached to the other side to separate the patch layer 1 from the particle attachment layer 3 and the release layer 4. The same package contains a particle attachment layer 3 with massage particles 5 of different sizes.

[0036] Among them, the massage particles 5 are made of gel material, and massage particles 5 of different sizes are distributed in three forms on the same particle attachment layer 3: the same size, the same size, and a mixture of sizes. The specific preparation process is as follows:

[0037] (1) Preparation of modified hydroxyapatite: Mix 95 mL Tris-hydrochloric acid buffer with 15 mL anhydrous ethanol, add 2.5 g hydroxyapatite, sonicate for 35 minutes, then add 1.2 g polydopamine solution 10 mg / mL, stir in the dark for 24 hours, and finally freeze dry to obtain modified hydroxyapatite.

[0038] (2) Preparation of modified chitosan: Dissolve 3.5g of chitosan in 4ml of 2% acetic acid solution, add 5mL of 20% hydrochloric acid solution, deoxygenate under nitrogen atmosphere for 20 minutes, then add 5g of gallic acid, and obtain solution one after complete dissolution; dissolve 3.5g of 1-ethyl-(3-dimethylaminopropyl)carbodiimide and 2g of N-hydroxysuccinimide in deionized water to obtain solution two; mix solution one and solution two under nitrogen atmosphere, dialyze for 24 hours using a dialysis bag with a molecular weight cutoff of 3.5kDa, and then freeze-dry to obtain modified chitosan;

[0039] (3) Preparation of massage granules 5: Mix 2g of hyaluronidase with 120mL of deionized water, and add 2.5g of vitamin C as an antioxidant to prevent enzyme inactivation in subsequent steps; after stirring evenly, preheat in a 37℃ constant temperature water bath for 15 minutes; add 1.5g of sodium periodate to the above solution, and stir at 200rpm for 3 hours under completely dark conditions using a magnetic stirrer; after the reaction is complete, add 5mL of 10% sodium thiosulfate solution to neutralize the remaining sodium periodate and prevent it from interfering with subsequent steps; add 4.5mL of ethylene glycol, and simultaneously add 0.2g of ethylenediaminetetraacetic acid to chelate existing metal ions and prevent them from affecting gel performance, and continue stirring for 60 minutes; The reaction solution was placed in deionized water and dialyzed using a dialysis bag with a molecular weight cutoff of 10 kDa for up to 24 hours to ensure thorough removal of small molecule impurities. Then, it was freeze-dried. 1.2 g of modified hydroxyapatite and 0.8 g of modified chitosan were added to a dried hyaluronidase-ethylene glycol mixture and ultrasonically stirred for 30 minutes until completely dissolved. Then, under ultrasonic stirring, stirring was continued for another 30 minutes to form a uniform gel. The gel was injected into a mold, and a freeze-thaw cycle was used to enhance its strength and stability. The freeze-thaw cycle consisted of freezing to -20°C, holding for 2 hours, and then thawing to room temperature, repeated three times. Finally, the mixture was cut and shaped as needed to obtain the final massage particles.

[0040] Example 3

[0041] A kinesiology patch with massage particles includes, from top to bottom, a patch layer 1, an adhesive layer 2, a particle attachment layer 3, and a release layer 4. The particle attachment layer 3 has a plurality of massage particles 5 on one side opposite to the release layer 4. The release layer 4 has a plurality of vent holes through which the massage particles 5 pass. The release layer 4 is bonded to the surface of the particle attachment layer 3. The adhesive layer 2 is coated on the surface of the patch layer 1. During packaging, release paper 6 is attached to the other side to separate the patch layer 1 from the particle attachment layer 3 and the release layer 4. The same package contains a particle attachment layer 3 with massage particles 5 of different sizes.

[0042] Among them, the massage particles 5 are made of gel material, and massage particles 5 of different sizes are distributed in three forms on the same particle attachment layer 3: the same size, the same size, and a mixture of sizes. The specific preparation process is as follows:

[0043] (1) Preparation of modified hydroxyapatite: Mix 100 mL of Tris-hydrochloric acid buffer with 20 mL of anhydrous ethanol, add 3.5 g of hydroxyapatite, sonicate for 35 minutes, then add 1.5 g of polydopamine solution at 10 mg / mL, stir in the dark for 24 hours, and finally freeze-dry to obtain modified hydroxyapatite.

[0044] (2) Preparation of modified chitosan: Dissolve 5g of chitosan in 4ml of 2% acetic acid solution, add 6mL of 20% hydrochloric acid solution, deoxygenate under nitrogen atmosphere for 20 minutes, then add 6g of gallic acid, and obtain solution one after complete dissolution; dissolve 4.2g of 1-ethyl-(3-dimethylaminopropyl)carbodiimide and 2.5g of N-hydroxysuccinimide in deionized water to obtain solution two; mix solution one and solution two under nitrogen atmosphere, dialyze for 24 hours using a dialysis bag with a molecular weight cutoff of 3.5kDa, and then freeze-dry to obtain modified chitosan;

[0045] (3) Preparation of massage granules 5: Mix 3g of hyaluronidase with 120mL of deionized water, and add 2.5g of vitamin C as an antioxidant to prevent enzyme inactivation in subsequent steps; after stirring evenly, preheat in a 37℃ constant temperature water bath for 15 minutes; add 2.5g of sodium periodate to the above solution, and stir at 200rpm for 3 hours under completely dark conditions using a magnetic stirrer; after the reaction is complete, add 5mL of 10% sodium thiosulfate solution to neutralize the remaining sodium periodate and prevent it from interfering with subsequent steps; add 5mL of ethylene glycol, and simultaneously add 0.2g of ethylenediaminetetraacetic acid to chelate existing metal ions and prevent them from affecting gel performance, and continue stirring for 60 minutes; The solution was placed in deionized water and dialyzed using a dialysis bag with a molecular weight cutoff of 10 kDa for up to 24 hours to ensure thorough removal of small molecule impurities. Then, it was freeze-dried. 1.2 g of modified hydroxyapatite and 0.8 g of modified chitosan were added to a dried hyaluronidase-ethylene glycol mixture and ultrasonically stirred for 30 minutes until completely dissolved. Then, under ultrasonic stirring, stirring was continued for another 30 minutes to form a uniform gel. The gel was injected into a mold, and a freeze-thaw cycle was used to enhance its strength and stability. The freeze-thaw cycle consisted of freezing to -20°C, holding for 2 hours, and then thawing to room temperature, repeated three times. Finally, the gel was cut and shaped as needed to obtain the final massage particles.

[0046] Comparative Example 1

[0047] Compared with Example 1, the difference is that the modified chitosan is replaced with chitosan; the rest remains the same.

[0048] Comparative Example 2

[0049] Compared with Example 1, the difference is that the modified hydroxyapatite is replaced with hydroxyapatite; the rest remains the same.

[0050] Using Escherichia coli (a Gram-negative bacterium, E. coli) and Staphylococcus aureus (a Gram-positive bacterium, S. aureus) as bacterial models, their metabolic activities were detected.

[0051] like Figure 1 and Figure 2 As shown, the kinesiology patches prepared in Examples 1-3 have significantly improved antibacterial properties compared to Comparative Examples 1-2.

[0052] In this process, hyaluronidase can degrade hyaluronic acid, thereby increasing the tissue's permeability and water retention capacity; vitamin C, as an antioxidant, can prevent hyaluronidase from being deactivated by oxidation during the preparation process, ensuring the smooth progress of the enzymatic hydrolysis reaction;

[0053] Sodium periodate can oxidize the hydroxyl groups in hyaluronic acid molecules to form aldehyde groups, thereby promoting cross-linking reactions; ethylene glycol, as a reducing agent, can reduce the aldehyde groups produced by the oxidation of sodium periodate, forming a stable cross-linked structure and enhancing the strength of the gel.

[0054] Ethylenediaminetetraacetic acid (EDTA) is a powerful metal ion chelating agent that can chelate metal ions in the reaction system, preventing them from interfering with gel formation and properties.

[0055] Modified hydroxyapatite possesses excellent biocompatibility and bone-bonding ability, which can enhance the bioactivity of the gel; while modified chitosan has good film-forming and antibacterial properties, which can further improve the stability and biosafety of the gel; in the preparation of modified hydroxyapatite, polydopamine, as a surface modifier, can improve the surface properties of hydroxyapatite, making it easier to combine with other components, while improving biocompatibility.

[0056] By optimizing the cross-linking reaction conditions and introducing stabilizers such as EDTA, the gel prepared using this process exhibits higher stability and can maintain its structure and properties for a longer period of time. Furthermore, the introduction of modified hydroxyapatite and modified chitosan, along with surface modification with polydopamine, enhances the gel's biocompatibility, reducing tissue irritation and inflammatory responses during use. It also possesses higher strength and elasticity, better adapting to the massage needs of different areas and improving the massage effect. Due to the improved stability and biocompatibility of the gel, the massage particles prepared using this process are less prone to deterioration and failure during use, thus extending their service life.

[0057] This process, by introducing auxiliary components such as antioxidants and metal ion chelators, and by optimizing dialysis and drying conditions, makes the preparation process more efficient and controllable.

[0058] Furthermore, any content not described in detail in this specification is existing technology known to those skilled in the art.

[0059] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0060] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A muscle-effect patch with massage particles, comprising, from top to bottom, a patch layer (1), an adhesive layer (2), a particle attachment layer (3), and a release layer (4), wherein the particle attachment layer (3) has a plurality of massage particles (5) disposed on one side opposite to the release layer (4), characterized in that: The isolation layer (4) is provided with several air vents, and the massage particles (5) pass through the air vents. The isolation layer (4) is bonded to the surface of the particle attachment layer (3). The adhesive layer (2) is coated on the surface of the patch layer (1). The side of the adhesive layer (2) facing away from the patch layer (1) is attached with release paper (6) during packaging, so that the patch layer (1) is packaged separately from the particle attachment layer (3) and the isolation layer (4). The same package contains a particle attachment layer (3) with massage particles (5) of different sizes. The massage particles (5) are made of gel material, and the massage particles (5) of different sizes are distributed in three forms on the same particle attachment layer (3): the same size, the same size, and a mixture of sizes. The specific preparation process of the massage particles (5) is as follows: S1 Mix 1.5-2.5g of hyaluronidase with 120mL of deionized water, add 0.5g of vitamin C as an antioxidant, stir well, and preheat in a 37℃ constant temperature water bath for 15 minutes. S2 Add 1.5-2g of sodium periodate to the above solution and stir at 200rpm for 3 hours under completely dark conditions using a magnetic stirrer; after the reaction is complete, add 5mL of 10% sodium thiosulfate solution. Add 4-5 mL of ethylene glycol to S3, along with 0.2 g of ethylenediaminetetraacetic acid, and continue stirring for 60 minutes; S4 The reaction solution was placed in deionized water and dialyzed using a dialysis bag with a molecular weight cutoff of 10 kDa for 24 hours, followed by freeze drying. S5. Add 1-1.2g of modified hydroxyapatite and 0.8-1.2g of modified chitosan to the dried hyaluronidase-ethylene glycol mixture, and sonicate for 30 minutes until completely dissolved; then continue stirring for 30 minutes to form a uniform gel. S6 The gel is injected into the mold, frozen to -20°C for 2 hours, and then thawed to room temperature. After repeating the freeze-thaw cycle 3 times, the gel is cut and shaped to obtain the final massage particles (5).

2. The muscle-relaxing patch with massage particles according to claim 1, characterized in that: In S5, the modified hydroxyapatite is prepared by mixing Tris-hydrochloric acid buffer with anhydrous ethanol, adding hydroxyapatite, sonicating for 35 minutes, then adding polydopamine solution, stirring in the dark for 24 hours, and finally freeze-drying to obtain modified hydroxyapatite.

3. A muscle-relaxing patch with massage particles according to claim 2, characterized in that: In the preparation of the modified hydroxyapatite, the amount of each component added is as follows: 90-100 mL of Tris-hydrochloric acid buffer, 10-20 mL of ethanol, 2-3.5 g of hydroxyapatite, and 0.8-1.5 g of polydopamine. The polydopamine solution is pre-dissolved in 10 mL of deionized water at a concentration of 10 mg / mL.

4. A muscle-relaxing patch with massage particles according to claim 1, characterized in that: In step S5, the modified chitosan is prepared as follows: chitosan is dissolved in acetic acid solution, hydrochloric acid solution is added dropwise, and deoxygenation is performed under a nitrogen atmosphere for 20 minutes. Then gallic acid is added, and solution one is obtained after complete dissolution. 1-ethyl-(3-dimethylaminopropyl)carbodiimide and N-hydroxysuccinimide are dissolved in deionized water to obtain solution two. Solution one and solution two are mixed under a nitrogen atmosphere, dialyzed for 24 hours using a dialysis bag with a molecular weight cutoff of 3.5 kDa, and then freeze-dried to obtain modified chitosan.

5. A muscle-relaxing patch with massage particles according to claim 4, characterized in that: In the preparation of the modified chitosan, the addition amounts of each component are as follows: chitosan 2.5-5g; acetic acid solution 4-7ml, with a concentration of 2%; deionized water 75-100mL; hydrochloric acid solution 4-6mL, with a concentration of 20%; gallic acid 3.5-6g; 1-ethyl-(3-dimethylaminopropyl)carbodiimide 2.8-4.2g; N-hydroxysuccinimide 1.6-2.5g.

6. A method for preparing a muscle-effect patch with massage particles according to any one of claims 1 to 5, characterized in that, The specific preparation method is as follows: the patch layer (1) and the particle attachment layer (3) are bonded together by the adhesive layer (2) to obtain the muscle effect patch with massage particles.

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