A midazolam maleate orally disintegrating tablet and a preparation method thereof

By optimizing the formulation and preparation process of midazolam maleate orally disintegrating tablets, the problems of drug stability and disintegration rate in emergency medical situations have been solved, meeting the needs of special patient groups and achieving rapid disintegration and stability.

CN119868290BActive Publication Date: 2026-07-03THE SEVENTH MEDICAL CENTER OF PLA GENERAL HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
THE SEVENTH MEDICAL CENTER OF PLA GENERAL HOSPITAL
Filing Date
2025-01-22
Publication Date
2026-07-03

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Abstract

The application belongs to the technical field of emergency sedative drug preparations, and relates to a midazolam maleate orally disintegrating tablet and a preparation method thereof. The formula of the midazolam maleate orally disintegrating tablet comprises midazolam maleate, a filler, a disintegrating agent, a lubricant and dithiothreitol. The formula and the preparation process of the midazolam maleate orally disintegrating tablet are optimized, the stability of the midazolam maleate is effectively improved, the content of related substances is low in the accelerated test, the active ingredient is stable, and in addition, due to good control of the formula and the process, the disintegration speed of the drug in the mouth and the taking experience of the patient are effectively balanced.
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