一株高利用水苏糖的普通拟杆菌及其缓解肠易激综合征的应用
By screening out the common Bacteroides CCFM1468 which efficiently utilizes stachyose, and combining it with stachyose intervention, the diarrhea symptoms of irritable bowel syndrome (IBS) were significantly relieved, the intestinal flora was regulated, and the shortcomings of existing technologies in relieving IBS by stachyose were solved, thus improving intestinal function.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- JIANGNAN UNIV
- Filing Date
- 2025-01-24
- Publication Date
- 2026-07-17
AI Technical Summary
Existing research has not been able to clarify whether stachyose can alleviate irritable bowel syndrome (IBS), and there is a lack of microorganisms that can synergistically promote the relief of IBS symptoms with stachyose.
A strain of Bacteroides vulgatus, CCFM1468, was provided, which has the ability to efficiently utilize stachyose. When used in combination with stachyose, it significantly increases the abundance of the strain in the host gut, reduces fecal water content, defecation frequency and gastrointestinal transit rate in mice with diarrhea-predominant irritable bowel syndrome, and regulates the levels of related cytokines.
The combined use of Bacteroides commonis CCFM1468 and stachyose can significantly alleviate diarrhea symptoms, reduce fecal water content and defecation frequency in mice, improve intestinal function, regulate the expression of related cytokines, and synergistically promote the improvement of symptoms of irritable bowel syndrome.
Smart Images
Figure CN119931885B_ABST