Method and system for determining factors related to ASD in burn patients

Abstract

The present invention discloses a method and system for determining the relevant factors for the occurrence of ASD in burn patients. The method first divides the patients into mild, moderate, severe and extremely severe burns according to the burn area, and records detailed personal information and other relevant data, such as gender, age, cause of injury, etc. Then, a psychiatrist diagnoses the burn patients for ASD according to the Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5), conducts a psychological assessment of the patients using the Acute Stress Disorder Scale (ASD-5), and uses near-infrared functional neuroradiography (fNIRS) to detect the hemodynamic response of specific brain areas to objectively reflect changes in brain functional state. Finally, through univariate analysis, two-sample correlation analysis and multivariate analysis, the key factors affecting the occurrence of ASD are systematically determined. In addition, the method also includes an assessment of the patient's quality of life, which helps to fully understand the patient's rehabilitation status and the degree of recovery of social function. Through early identification and intervention, the present invention can significantly improve the quality of life and rehabilitation effect of burn patients.

Description

Technical Field

[0001] The present invention relates to the field of mental health technology, and in particular to a method for determining the relationship between ASD and burn area. Background Art

[0002] Burns are a common traumatic illness, requiring patients to not only endure lengthy treatment but also experience severe psychological stress. Acute stress disorder (ASD) is a common psychological problem among burn patients, severely impacting their quality of life and recovery. ASD typically develops within three days to one month after the traumatic event and is characterized by symptoms such as intrusiveness, negative mood, dissociation, avoidance, and arousal.

[0003] Currently, the main methods for assessing ASD in burn patients include psychological scale assessment and clinical diagnosis. Commonly used psychological scales include the Acute Stress Disorder Scale-5 (ASD-5), which assess the severity of patients' symptoms through self-assessment or peer assessment. In addition, some studies have used brain function testing technologies, such as functional near-infrared spectroscopy (fNIRS), to assist in the diagnosis of ASD. fNIRS reflects the functional state of the brain by monitoring changes in hemoglobin concentration in the cerebral cortex and has achieved significant results in the diagnosis of psychiatric disorders such as depression, bipolar disorder, and schizophrenia.

[0004] Although existing psychological scales and brain function testing technologies have made some progress in the assessment of ASD, some shortcomings still exist. First, psychological scale assessments rely on patient self-reports and are easily influenced by subjective factors, resulting in low accuracy of assessment results. Second, although existing brain function testing technologies such as fNIRS can provide information on brain functional status, in actual application, data processing is complex, requiring professional technicians and long analysis time, making it difficult to widely apply in clinical practice. Finally, existing assessment methods fail to fully consider the impact of burn area on the occurrence of ASD and cannot provide clinicians with a comprehensive assessment tool. Summary of the Invention

[0005] In view of the above defects or improvement needs of the prior art, the object of the present invention is to provide a method for determining the relationship between ASD and burn area.

[0006] According to a first aspect of the present invention, a method for determining factors associated with the development of ASD in burn patients is provided, comprising:

[0007] S100. Select multiple burn patients who meet the inclusion criteria, classify them according to the burn area, and record the burn grade and other relevant information of the patients;

[0008] S200, performing cerebral hemodynamic activity detection using near-infrared brain functional imaging technology while the multiple burn patients perform a speech fluency task, and recording the detection data respectively;

[0009] S300, calculating the S integral values ​​of six brain regions of interest, namely, the left Broca's area, the right Broca's area, the left dorsolateral prefrontal lobe, the right dorsolateral prefrontal lobe, the left frontal pole, and the right frontal pole, based on the detection data;

[0010] S400, evaluating and recording the ASD conditions of the multiple burn patients using the Acute Stress Disorder Rating Scale;

[0011] S500. Perform univariate analysis, two-sample correlation analysis, and multivariate analysis based on the burn levels of the multiple burn patients, other relevant information, the S-score values ​​of the six areas of interest, and the ASD conditions of the multiple burn patients, and determine the relevant factors for the occurrence of ASD in burn patients based on the analysis results.

[0012] Furthermore, step S100 also includes evaluating the quality of life of the burn patient after the illness and recording the quality of life score.

[0013] Furthermore, the burn levels in step S100 include: mild burn, moderate burn, severe burn and extremely severe burn.

[0014] Furthermore, the other relevant information in step S100 includes gender, age, whether it is flame burn, third-degree burn area, ABSI score, measurement time after injury, whether it is inhalation injury, whether multiple burns, whether married, and quality of life score.

[0015] Furthermore, step S200 includes: recording and displaying a curve of HbO concentration changing with time during the speech fluency task, and the area under the final curve is the measured S integral value.

[0016] Furthermore, the calculation of the S integral value includes:

[0017]

[0018] Where IV represents the S integral value; t represents the time point; and f(t) represents the oxygenated hemoglobin concentration at time point t.

[0019] Furthermore, the language fluency task includes a 30-second pre-task baseline, a 60-second word formation task, and a 60-second post-task baseline.

[0020] Furthermore, during the 60-second word formation task, the patient needs to form words as much as possible according to the Chinese characters prompted by the voice every 15 seconds, and repeat this four times.

[0021] Furthermore, the S integral value is an indicator for measuring the intensity of cerebral hemodynamic response. By calculating the area under the curve of the change of oxyhemoglobin concentration over time during the task period, it reflects the increase in oxyhemoglobin concentration during the language fluency task, and further reflects the degree of brain area activation.

[0022] According to a second aspect of the present invention, a system for determining factors associated with the occurrence of ASD in burn patients is provided, comprising:

[0023] In the first module, multiple burn patients who meet the inclusion criteria are selected, graded according to the burn area, and the burn grade and other relevant information of the patients are recorded;

[0024] The second module is to use near-infrared brain functional imaging technology to detect cerebral hemodynamic activity while the multiple burn patients perform a speech fluency task, and record the detection data respectively;

[0025] The third module calculates the S integral values ​​of the six brain regions of interest, namely, the left Broca's area, the right Broca's area, the left dorsolateral prefrontal lobe, the right dorsolateral prefrontal lobe, the left frontal pole, and the right frontal pole, based on the detection data;

[0026] The fourth module is to evaluate and record the ASD conditions of the multiple burn patients using the Acute Stress Disorder Scale;

[0027] The fifth module conducts univariate analysis, two-sample correlation analysis, and multivariate analysis based on the burn levels, other relevant information, S-score values ​​of the six areas of interest, and the ASD conditions of the multiple burn patients, and determines the relevant factors for the occurrence of ASD in burn patients based on the analysis results.

[0028] Beneficial effects of the present invention:

[0029] 1. This method first divides patients into mild, moderate, severe and extremely severe burns according to the area of ​​burns, and records detailed personal information and other relevant data, such as gender, age, cause of injury, etc. Then, the patient is psychologically assessed using the Acute Stress Disorder Scale (ASD-5), and near-infrared functional brain imaging technology (fNIRS) is used to detect the hemodynamic response of specific brain areas to objectively reflect changes in brain functional state. Finally, through univariate analysis, two-sample correlation analysis and multivariate analysis, the key factors affecting the occurrence of ASD are systematically determined. By early identification of risk factors for ASD in burn patients, effective psychological intervention measures can be taken in a timely manner to effectively improve the patient's quality of life and rehabilitation effect, and reduce the occurrence of long-term psychological problems. In addition, this method also includes an assessment of the patient's quality of life, which helps to fully understand the patient's rehabilitation status and the degree of recovery of social function. Through early identification and intervention, the present invention can significantly improve the quality of life and rehabilitation effect of burn patients.

[0030] Additional aspects and advantages of the present application will be given in part in the following description, which will become apparent from the following description, or will be learned through practice of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] The above and / or additional aspects and advantages of the present application will become apparent and easily understood from the following description of the embodiments in conjunction with the accompanying drawings, in which:

[0032] Figure 1 4 is a flow chart of a method for determining relevant factors for the occurrence of ASD in burn patients according to an embodiment of the present invention. DETAILED DESCRIPTION

[0033] The present invention will be further described in detail below with reference to the accompanying drawings and examples. It will be understood that the specific embodiments described herein are intended only to illustrate the present invention and are not intended to limit the present invention. It should also be noted that, for ease of description, the accompanying drawings only illustrate portions relevant to the present invention, not all structures.

[0034] Those skilled in the art will understand that, unless otherwise stated, the singular forms "a," "an," "said," and "the" used herein may also include plural forms. It should be further understood that the term "comprising" used in the specification of this application refers to the presence of the stated features, integers, steps, operations, elements, and / or components, but does not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and / or combinations thereof.

[0035] Those skilled in the art will understand that, unless otherwise defined, all terms used herein (including technical and scientific terms) have the same meaning as those generally understood by those skilled in the art to which this application belongs. It should also be understood that terms such as those defined in general dictionaries should be understood to have meanings consistent with those in the context of the prior art, and will not be interpreted in an idealized or overly formal sense unless specifically defined as in the examples of this application.

[0036] The present invention provides a method and system for identifying factors associated with the development of ASD in burn patients. This method first categorizes patients into mild, moderate, severe, and extremely severe burns based on the area of ​​burn injury, and records detailed personal information and other relevant data, such as gender, age, and cause of injury. Next, the patient undergoes a psychological assessment using the Acute Stress Disorder Scale-5 (ASD-5), and functional near-infrared MRI (fNIRS) is used to measure hemodynamic responses in specific brain regions to objectively reflect changes in brain function. Finally, through univariate analysis, two-sample correlation analysis, and multivariate analysis, the key factors influencing the development of ASD are systematically identified. By early identifying risk factors for ASD in burn patients, effective psychological intervention measures can be implemented promptly, effectively improving patients' quality of life and rehabilitation outcomes, and reducing the occurrence of long-term psychological problems. Furthermore, this method includes an assessment of the patient's quality of life, which helps to fully understand the patient's rehabilitation status and the degree of recovery of social function. Through early identification and intervention, the present invention can significantly improve the quality of life and rehabilitation outcomes of burn patients.

[0037] Example 1:

[0038] like Figure 1 As shown, an embodiment of the present invention provides a method for determining factors related to the occurrence of ASD in burn patients, comprising:

[0039] S100. Select burn patients who meet the inclusion criteria, classify them according to the burn area, and record the burn grade and other relevant information of the patients;

[0040] S200. Assess the ASD status of the burn patient using a psychometric questionnaire, wherein patients within one month after injury are assessed using the Acute Stress Disorder Scale, and patients more than one month after injury are assessed using the Post-Traumatic Stress Disorder Scale;

[0041] S300: Use near-infrared brain functional imaging technology to test the patient's brain function and calculate the S integral values ​​of the six areas of interest: left Broca's area, right Broca's area, left dorsolateral area, right dorsolateral area, left frontal pole, and right frontal pole;

[0042] S400. Perform univariate analysis, two-sample correlation analysis, and multivariate analysis based on the patient's burn grade, other relevant information, ASD score, and S-score values ​​of the six areas of interest, and determine the relevant factors for the occurrence of ASD in burn patients based on the analysis results.

[0043] Example 2:

[0044] The present invention provides a specific experimental method process and results for determining factors associated with the development of ASD in burn patients, including:

[0045] S1. Set the inclusion and exclusion criteria for the experimental subjects. The inclusion criteria are: (1) burn patients caused by various causes of injury; (2) aged 18-65 years; (3) no limit on the total area of ​​burns; (4) able to communicate effectively and cooperate with the relevant tests of this experiment; (5) willing to participate in this experiment after informed consent. The exclusion criteria are: (1) death within 3 days after injury; (2) organic brain disease, especially metal foreign bodies in the skull; (3) history of mental illness; (4) dependence on or abuse of psychoactive substances; (5) currently taking or having taken psychotropic drugs within 2 weeks before the start of this experiment; (6) pregnant or breastfeeding women; (7) patients with severe immune or endocrine diseases; (8) lack of necessary clinical data.

[0046] S2. A cross-sectional survey was conducted to enroll 121 burn patients who met the inclusion criteria and were admitted to the Burn Department of Wuhan Third Hospital between May 2024 and September 2024. There were 87 males (71.9%) and 34 females (28.1%), aged 42 (32, 52) years, with a total burn area of ​​21% (7.5%, 48%) TBSA and an Abbreviated Burn Severity Index (ABSI) score of 12.5 (4.4, 32). According to the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders, the diagnostic criteria for acute stress disorder (ASD) are nine or more of the 14 symptoms in five categories: intrusion, negative mood, dissociation, avoidance, and arousal. These symptoms begin or worsen after the traumatic event and last from three days to one month after the trauma. They cause clinically significant distress or lead to impairment in social, occupational, or other important functions and cannot be attributed to the physiological effects of a substance (such as drugs or alcohol) or other medical illness, and cannot be explained by "brief psychotic disorder."

[0047] S3. Based on clinical experience and literature reports, this study collected patient data on injury time, post-injury measurement of psychological scales and brain function, gender, age, cause of injury, total burn area, third-degree burn area, ABSI score, inhalation injury, multiple burns (i.e., three or more burn sites), marital status, and ICU admission during the shock period. Patients were categorized according to burn area as mild (<10% TBSA), moderate (10-29% TBSA), severe (30-49% TBSA), and very severe (≥50% TBSA).

[0048] S4. Patients 3 days to 1 month after injury were assessed with the Acute Stress Disorder Scale for DSM-5 (ASD-5). The scale consists of 14 questions, each with a score of 1-5, for a total score of 14-70. Higher scores indicate more severe symptoms. The test-retest reliability of this scale is 0.94, and its internal consistency is 0.96. Patients more than 1 month after injury were assessed with the Post-Traumatic Stress Disorder Scale for DSM-5 (revised version). The scale consists of 20 questions, each with a score of 0-4, for a total score of 0-80. Higher scores indicate more severe symptoms. The test-retest reliability of this scale is 0.84, and its validity is 0.87. All patients were assessed using the brief version of the Burn Specific Health Scale (BSHS-B). The 40-question scale, with each question scored from 0 to 4 points and a total score of 0 to 160, indicates a higher quality of life. The test-retest reliability of the scale was 0.95, and the internal consistency was 0.93.

[0049] S5. Functional near-infrared (fNIRS) imaging is widely used as a non-invasive diagnostic technique in clinical psychiatric diagnosis and treatment. The VFT paradigm, in particular, has a well-established literature base in clinical research on psychiatric disorders. Studies have shown that this technique can aid in the clinical diagnosis of psychiatric disorders, with current research focusing on the neural mechanisms and clinical neurobiomarkers of depression, bipolar disorder, and schizophrenia. In this study, all patients underwent brain function testing using a 53-channel fNIRS device (BS-3000, Zilian Hongkang Technology Co., Ltd., China). The device measured changes in hemoglobin concentration in the prefrontal cortex using near-infrared light at wavelengths of 690 and 830 nm. Each channel consisted of a light-source / detector pair separated by 3 cm, arranged according to a 10-20 system (with optode No. 9 located at the fpz). Sixteen light sources and 16 receivers comprised a total of 53 channels. To analyze the characteristics of blood oxygenation changes in different regions of interest (ROIs), the frontal lobe and left and right temporal lobes were selected for analysis, resulting in six ROIs: the left and right Broca's areas (Broca-L and Broca-R), the left and right dorsolateral lateral lobes (DLPFC-L and DLPFC-R), and the left and right frontal poles (FPA-L and FPA-R). This experiment used a verbal fluency task (VFT) to observe changes in brain oxygenation and hemoglobin (HbO), deoxyhemoglobin, and total hemoglobin concentrations. The S-integral value is a widely used indicator in VFT-fNIRS studies. Numerous studies have shown this indicator to be an effective neurobiomarker, aiding in the diagnosis and identification of various psychiatric disorders. The S-integral value is calculated as follows: where t is the time point and t is the HbO concentration at that moment. The integral value was calculated during the task period, i.e., 0-60 seconds after the start of the task, and only HbO concentrations greater than 0 at that moment were included in the integral calculation. The S-integral value is an indicator that measures the intensity of cerebral hemodynamic response. By calculating the area under the curve of HbO concentration changes over time during the task period, it reflects the increase in HbO concentration during the task period and thus reflects the degree of brain area activation. Its sensitivity for diagnosing and identifying mental and psychological disorders is 0.759-0.900, and its specificity is 0.833-0.889.

[0050] S6. Statistical analysis. This experiment processed fNIRS data using Matlab 2014b software, primarily using Homer2, NIRS_KIT, and self-written Matlab scripts. Statistical analysis was performed to determine whether there was significant activation of the S-score values ​​of the regions of interest between groups. Data were analyzed using SPSS 22.0. Non-normally distributed measurement data were expressed using M (P25, P75), and inter-group comparisons were performed using the Mann-Whitney U test for two independent samples. Count data were expressed as frequencies (percentages) and subjected to the chi-square test or Fisher's exact probability method. Pearson correlation analysis was used for two-sample correlation analysis. Multivariate logistic regression analysis of ASD in burn patients was performed, combining univariate differences and clinical significance as independent variables. P < 0.05 was considered statistically significant.

[0051] The experimental results are as follows:

[0052] 1. As shown in Table 1, 62 burn patients in this study were required to be evaluated for ASD, of whom 16 (25.8%) were in the ASD-positive group and 46 (71.2%) were in the ASD-negative group. The burn area of ​​the 62 burn patients ranged from 0.2% to 55.0% TBSA, and the patients were 3-30 days after injury. The ASD-positive group and the ASD-negative group were significantly different in terms of gender (P=0.681), age (P=0.753), whether there was flame burn (P=0.190), burn area (P=0.573), third-degree burn area (P=0.935), ABSI score (P=0.601), time after injury (P=0.100), whether there was inhalation injury (P=1.000), whether there were multiple burns (P=0.378), and whether the patient was married (P= There were no significant differences in the ASD-positive group's Broca-L (P=0.025), DLPFC-L (P=0.004), FPA-L (P=0.025), DLPFC-R (P=0.021), and FPA-R (P=0.016) S scores compared with the ASD-negative group.

[0053] Table 1

[0054]

[0055] 3. As shown in Table 2, this study showed that the ASD scores of burn patients had no statistically significant correlation with age (P=0.733) or burn area (P=0.673), but had statistically significant correlations with the S-score values ​​of Broca-L (P=0.039), DLPFC-L (P=0.005), FPA-L (P=0.017), DLPFC-R (P=0.005), and FPA-R (P=0.029). In addition, there was no statistically significant correlation between the burn area and age (0.088), Broca-L (P=0.488), DLPFC-L (P=0.952), FPA-L (P=0.273), Broca-R (P=0.199), DLPFC-R (P=0.744), and FPA-R (P=0.756) of burn patients. Age was negatively correlated with the S-score values ​​of DLPFC-L (P=0.015), FPA-L (P=0.009), and FPA-R (P=0.030).

[0056] Table 2

[0057]

[0058] Burns not only cause direct short-term damage to soft tissues such as the skin, but also indirect long-term damage to various systems and organs throughout the body. Burns, in particular, affect the neuro-endocrine-immune system, causing patients to experience severe physical and psychological distress years after the burn. Burns should be considered a chronic disease. This study found that the development of ASD after burns was not significantly related to the burn area, and that patients with small burns may also develop ASD. This suggests that in clinical practice, regardless of the size of the burn area, ASD screening can be carried out as early as possible when the patient's condition is stable, and intervention can be performed for patients with obvious ASD symptoms to reduce the patient's psychological distress and the possibility of chronic psychological problems that may result. This result is similar to the findings of previous international studies, indicating that burns, as sudden accidental injuries, bring psychological shock to patients, and that prompt attention should be paid to patients' acute stress reactions in the early stages of hospitalization.

[0059] Currently, the diagnosis and identification of emotional issues in burn patients relies primarily on the experience of burn clinicians and psychological scales, but the actual identification rate is poor. Brain function measured using fNIRS can provide objective data to guide clinical understanding of the patient's condition and improve diagnostic identification rates. This study found that brain function in multiple brain regions of patients with ASD was significantly lower than that of patients with ASD-negative conditions, suggesting that brain function testing can assist in the timely identification of patients with ASD. This study, using objective brain function data, suggests that patients who develop ASD after burns have significantly reduced prefrontal cortex function, providing data support for burn clinicians to pay attention to patients' psychological status.

[0060] It should be understood that although the steps in the flowcharts of the accompanying drawings are shown in sequence as indicated by the arrows, these steps are not necessarily executed in the order indicated by the arrows. Unless otherwise specified herein, there is no strict order restriction on the execution of these steps, and they can be executed in other orders. Moreover, at least some of the steps in the flowcharts of the accompanying drawings may include multiple sub-steps or multiple stages, and these sub-steps or stages are not necessarily executed at the same time, but can be executed at different times, and their execution order is not necessarily sequential, but can be executed in turn or alternately with other steps or at least a portion of the sub-steps or stages of other steps.

[0061] The above description is only part of the implementation methods of the present application. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present application. These improvements and modifications should also be regarded as the scope of protection of the present application.

Claims

1. A method for determining factors associated with the occurrence of ASD in burn patients, characterized in that: include: S100. Select multiple burn patients who meet the inclusion criteria, classify them according to the burn area, and record the burn grade and other relevant information of the patients; S200, using near-infrared brain functional imaging technology to detect cerebral hemodynamic activity while the multiple burn patients perform a language fluency task, and recording the detection data respectively; including: Record and display a curve of HbO concentration changing over time during the language fluency task, and the area under the final curve is the measured S integral value; The calculation of the S integral value includes: Where, IV represents the S integral value; t represents the time point; represents the concentration of oxygenated hemoglobin at time point t; The S-integral value is an indicator of the intensity of cerebral hemodynamic response. By calculating the area under the curve of the change of oxyhemoglobin concentration over time during the task period, it reflects the increase in oxyhemoglobin concentration during the language fluency task, and further reflects the degree of brain area activation. S300, calculating the S integral values ​​of six brain regions of interest, namely, the left Broca's area, the right Broca's area, the left dorsolateral prefrontal lobe, the right dorsolateral prefrontal lobe, the left frontal pole, and the right frontal pole, based on the detection data; S400, evaluating and recording the ASD conditions of the multiple burn patients using the Acute Stress Disorder Rating Scale; S500. Perform univariate analysis, two-sample correlation analysis, and multivariate analysis based on the burn levels of the multiple burn patients, other relevant information, the S-score values ​​of the six areas of interest, and the ASD conditions of the multiple burn patients, and determine the relevant factors for the occurrence of ASD in burn patients based on the analysis results.

2. The method for determining the related factors of ASD in burn patients according to claim 1, characterized in that: Step S100 also includes evaluating the quality of life of the burn patient after the illness and recording the quality of life score.

3. The method for determining the related factors of ASD in burn patients according to claim 1, characterized in that: The burn levels in step S100 include: mild burn, moderate burn, severe burn and extremely severe burn.

4. The method for determining the related factors of ASD in burn patients according to claim 1, characterized in that: The other relevant information in step S100 includes gender, age, whether it is a flame burn, the area of ​​third-degree burn, ABSI score, measurement time after injury, whether it is an inhalation injury, whether it is multiple burns, whether the patient is married, and quality of life score.

5. The method for determining the related factors of ASD in burn patients according to claim 1, characterized in that: The language fluency task included a 30-second pre-task baseline, a 60-second word formation task, and a 60-second post-task baseline.

6. The method for determining the related factors of ASD in burn patients according to claim 5, characterized in that: During the 60-second word formation task, the patient needs to form words as much as possible according to the Chinese characters prompted by the voice every 15 seconds, and repeat this four times.

7. A system for determining factors associated with the occurrence of ASD in burn patients, characterized in that: include: In the first module, multiple burn patients who meet the inclusion criteria are selected, graded according to the burn area, and the burn grade and other relevant information of the patients are recorded; The second module uses near-infrared brain functional imaging technology to detect cerebral hemodynamic activity while the multiple burn patients perform a language fluency task, and records the detection data. This includes recording and displaying a curve of HbO concentration changes over time during the language fluency task, and the area under the final curve is the measured S integral value; The calculation of the S integral value includes: Where, IV represents the S integral value; t represents the time point; represents the concentration of oxygenated hemoglobin at time point t; The S-integral value is an indicator of the intensity of cerebral hemodynamic response. By calculating the area under the curve of the change of oxyhemoglobin concentration over time during the task period, it reflects the increase in oxyhemoglobin concentration during the language fluency task, and further reflects the degree of brain area activation. The third module calculates the S integral values ​​of the six brain regions of interest, namely, the left Broca's area, the right Broca's area, the left dorsolateral prefrontal lobe, the right dorsolateral prefrontal lobe, the left frontal pole, and the right frontal pole, based on the detection data; The fourth module is to evaluate and record the ASD conditions of the multiple burn patients using the Acute Stress Disorder Scale; The fifth module conducts univariate analysis, two-sample correlation analysis, and multivariate analysis based on the burn levels, other relevant information, S-score values ​​of the six areas of interest, and the ASD conditions of the multiple burn patients, and determines the relevant factors for the occurrence of ASD in burn patients based on the analysis results.

Images