Zinc oxide feed additive suitable for piglets and application thereof

Abstract

The invention discloses a zinc oxide feed additive suitable for piglets and application of the zinc oxide feed additive, and belongs to the field of livestock feed. The zinc oxide feed additive suitable for the piglets, provided by the invention, contains the following components in parts by weight: 1-2 parts of zinc oxide, 1-3 parts of astragalus polysaccharide, 2-3 parts of an oregano extract, 2-4 parts of a folium cortex eucommiae extract and 1-2 parts of beta-glucan. According to the zinc oxide feed additive disclosed by the invention, the growth of piglets is promoted by utilizing zinc oxide, and meanwhile, the astragalus polysaccharide, the oregano extract, the folium cortex eucommiae extract and the beta-glucan are also introduced to relieve negative effects caused by zinc oxide, so that the conversion rate and the absorption rate of the piglets to the feed are improved, the piglets can grow quickly, and the feeding cost is reduced.

Description

Technical Field

[0001] The invention belongs to the field of livestock feed and relates to a zinc oxide feed additive suitable for piglets and application thereof. Background Art

[0002] The piglet stage is one of the most important links in the pig farming process. Early weaning stress in piglets can cause intestinal microbial disorders, mucosal immune damage and nutrient absorption disorders, which in turn lead to decreased production performance, diarrhea, and even death. Data show that the mortality rate in the piglet stage accounts for more than 85% of the entire pig farming process, causing significant economic losses to the pig farming industry. Before the ban on antibiotics in feed, the addition of feed antibiotics and related drugs was one of the main measures to prevent and treat piglet weaning stress syndrome, but it would lead to the production of drug-resistant strains and drug residues in animal-derived foods, which had many adverse effects on human health and the environment. After the ban on antibiotics in feed, zinc oxide, probiotics, prebiotics, antimicrobial peptides, organic acids and essential oils were used as antibiotic substitutes to alleviate diarrhea in weaned piglets and improve piglet growth performance.

[0003] Although zinc oxide can promote the health and growth performance of piglets, zinc is a heavy metal after all and is toxic to most living organisms, including piglets themselves. Long-term use of feed containing excessively high concentrations of zinc can cause animals to develop symptoms of poisoning. These symptoms include growth retardation, loss of appetite, indigestion, alternating diarrhea or constipation, and in severe cases may even cause damage to organs such as the liver and kidneys, thereby affecting the overall health of piglets and breeding benefits. Summary of the invention

[0004] The present invention aims to develop a zinc oxide feed additive suitable for piglets and an application thereof, and utilize zinc oxide to promote the growth of piglets, thereby reducing the negative effects caused by zinc poisoning and improving the survival rate and growth performance of piglets.

[0005] In a first aspect, the present invention provides a zinc oxide feed additive suitable for piglets, wherein the zinc oxide feed additive comprises, by weight: 1 to 2 parts of zinc oxide, 5 to 10 parts of plant extract, and 1 to 2 parts of β-glucan;

[0006] The plant extracts are astragalus polysaccharide, oregano extract and eucommia leaf extract.

[0007] Furthermore, in the zinc oxide feed additive suitable for piglets of the present invention, the mass ratio of the astragalus polysaccharide, the oregano extract and the eucommia leaf extract is 1-3:2-3:2-4.

[0008] Furthermore, the zinc oxide feed additive suitable for piglets contains, by weight: 1-2 parts of zinc oxide, 1-3 parts of astragalus polysaccharide, 2-3 parts of oregano extract, 2-4 parts of eucommia leaf extract, and 1-2 parts of β-glucan.

[0009] Furthermore, the zinc oxide feed additive suitable for piglets contains, by weight: 15 parts of zinc oxide, 20 parts of astragalus polysaccharide, 30 parts of oregano extract, 20 parts of eucommia leaf extract, and 15 parts of β-glucan.

[0010] In a second aspect, the present invention also provides the use of a zinc oxide feed additive suitable for piglets.

[0011] Furthermore, the added amount of the zinc oxide feed additive of the present invention accounts for 0.8% to 1.3% of the total weight of the piglet feed.

[0012] Compared with the prior art, the technical solution provided by the present invention has at least the following beneficial effects or advantages:

[0013] (1) The zinc oxide feed additive of the present invention significantly increases the feed intake and feed conversion efficiency of piglets, promotes growth, and reduces breeding costs. Specifically, after adding the zinc oxide feed additive to the conventional piglet diet, the average daily feed intake of the piglets in the test group increased significantly by 19.55% compared with the conventional diet group. At the same time, the zinc oxide feed additive also reduced the feed-to-weight ratio of the test group to 1.50, further optimizing the utilization efficiency of the feed. Furthermore, the average daily weight gain of the piglets in the test group achieved an increase of 52.92%, proving the effect of the zinc oxide additive in promoting the growth of piglets.

[0014] (2) The combined use of zinc oxide, plant extracts and β-glucan significantly improved the diarrhea condition of piglets, and the incidence of diarrhea in piglets dropped from 8.75% to 0, indicating that the zinc oxide feed additive of the present invention can not only promote the growth and development of piglets, but also effectively reduce the incidence of diarrhea, thereby improving the breeding effect. DETAILED DESCRIPTION

[0015] The technical scheme of the present invention is described below in conjunction with the embodiments, but the present invention is not limited to the following embodiments. The experimental methods and detection methods described in each embodiment are conventional methods unless otherwise specified; the reagents and materials described are all commercially available unless otherwise specified.

[0016] In the following examples, zinc oxide was purchased from Leshengyuan Biotechnology (Nanjing) Co., Ltd.; astragalus polysaccharide was purchased from Wuhan Huajiu Pharmaceutical Technology Co., Ltd.; oregano extract was purchased from Xi'an Youshuo Biotechnology Co., Ltd.; eucommia leaf extract was purchased from Shaanxi Chenming Biotechnology Co., Ltd.; β-glucan was purchased from Jiangsu Caiwei Biotechnology Co., Ltd.

[0017] Example 1

[0018] This embodiment provides a zinc oxide feed additive suitable for piglets.

[0019] The zinc oxide feed additive suitable for piglets described in this embodiment contains: zinc oxide, plant extracts and β-glucan, the plant extracts are astragalus polysaccharide, oregano extract and eucommia leaf extract, and the mass ratio of astragalus polysaccharide, oregano extract and eucommia leaf extract is 1:2:2.

[0020] Calculated by weight, the contents of the components of the zinc oxide feed additive suitable for piglets are: 10 parts of zinc oxide, 10 parts of astragalus polysaccharide, 20 parts of oregano extract, 20 parts of eucommia leaf extract, and 20 parts of beta-glucan.

[0021] Mix the above components in the required proportions, seal them in a well-sealed plastic bag and use them as feed additives for later use.

[0022] Zinc oxide feed additive was added to the piglet diet, the addition amount of the zinc oxide feed additive accounted for 0.8% of the total weight of the piglet feed, the average daily weight gain of the piglets was 229.05 g / d, the average feed intake was 347.88 g / d, the feed-to-weight ratio was 1.52, and no diarrhea occurred.

[0023] Example 2

[0024] This embodiment provides a zinc oxide feed additive suitable for piglets.

[0025] The zinc oxide feed additive suitable for piglets described in this embodiment contains: zinc oxide, plant extracts and β-glucan, the plant extracts are astragalus polysaccharide, oregano extract and eucommia leaf extract, and the mass ratio of astragalus polysaccharide, oregano extract and eucommia leaf extract is 2:3:2.

[0026] Calculated by weight, the contents of the components of the zinc oxide feed additive suitable for piglets are: 15 parts of zinc oxide, 20 parts of astragalus polysaccharide, 30 parts of oregano extract, 20 parts of eucommia leaf extract, and 15 parts of beta-glucan.

[0027] Mix the above components in the required proportions, seal them in a well-sealed plastic bag and use them as feed additives for later use.

[0028] Zinc oxide feed additive was added to the piglet diet, the addition amount of the zinc oxide feed additive accounted for 1.0% of the total weight of the piglet feed, the average daily weight gain of the piglets was 237.27 g / d, the average feed intake was 356.66 g / d, the feed-to-weight ratio was 1.50, and no diarrhea occurred.

[0029] Example 3

[0030] This embodiment provides a zinc oxide feed additive suitable for piglets.

[0031] The zinc oxide feed additive suitable for piglets described in this embodiment contains: zinc oxide, plant extracts and β-glucan, the plant extracts are astragalus polysaccharide, oregano extract and eucommia leaf extract, and the mass ratio of astragalus polysaccharide, oregano extract and eucommia leaf extract is 3:3:4.

[0032] Calculated by weight, the contents of the components of the zinc oxide feed additive suitable for piglets are: 20 parts of zinc oxide, 30 parts of astragalus polysaccharide, 30 parts of oregano extract, 40 parts of eucommia leaf extract, and 10 parts of beta-glucan.

[0033] Mix the above components in the required proportions, seal them in a well-sealed plastic bag and use them as feed additives for later use.

[0034] Zinc oxide feed additive was added to the piglet diet, the addition amount of the zinc oxide feed additive accounted for 1.3% of the total weight of the piglet feed, the average daily weight gain of the piglets was 212.32 g / d, the average feed intake was 320.18 g / d, the feed-to-weight ratio was 1.51, and no diarrhea occurred.

[0035] Example 4

[0036] This embodiment provides an experimental method for feeding piglets with zinc oxide feed additive.

[0037] 1. Preliminary preparations for the test

[0038] In this example, 400 DLY piglets with similar weaning weight at 25 days of age were selected and divided into 5 treatment groups, with 80 piglets in each treatment group. The piglets were pre-fed in the farrowing house 3 days before weaning, and then transferred to the nursery house for feeding and experiment. The grouping of each experimental group is shown in Table 1.

[0039] Table 1 Experimental grouping

[0040]

[0041] The dietary composition and nutritional level of each experimental group are shown in Table 2:

[0042] Table 2 Diet composition and nutritional level of each experimental group

[0043]

[0044]

[0045] Note: The composition and content of the premix are: 4500000IU / kg vitamin A, 750000IU / kg vitamin D 3 , 5000IU / kg vitamin E, 500mg / kg vitamin K 3 , 600mg / kg vitamin B 1 , 30mg / kg biotin, 2000mg / kg vitamin B 2 , 100mg / kg vitamin B 6 , 8mg / kg vitamin B 12 , 100mg / kg folic acid, 8000mg / kg nicotinamide, 4500mg / kg D-pantothenic acid

[0046] 2. Animal Management

[0047] The experiment was conducted in April 2024 at the pig farm of Xinjiang Taikun Group Co., Ltd. in Changji City, Changji Hui Autonomous Prefecture. Animal feeding and management were carried out in accordance with the conventional management methods for early weaned piglets, and the temperature in the house was controlled at 25-26°C; the feed was powdered, and an appropriate amount of 70-80°C hot water was added to mix the feed into a liquid feed in the first week after the piglets were weaned. The feed was fed in a small amount and frequently added manner. It was advisable to have a little surplus feed in the feeding trough each time, and free drinking water. The feed intake of the experimental pigs was recorded in detail every day, and the pigs' defecation, urination, feeding patterns and health status were observed at any time and recorded. The formal trial period was 2 weeks, and the litters were weighed at the beginning and end of the trial. The test results were the average value of each litter of piglets.

[0048] Example 5

[0049] This example provides the changes in production performance of piglets in each test group.

[0050] 1. Growth performance analysis of each experimental group

[0051] The growth performance of the control group, test group 1, test group 2, test group 3, test group 4 and test group 5 during the test period is shown in Table 3. The weight difference of each test group in the initial stage is not large, indicating that the actual difference in weight of each test group is not enough to affect the test results. From the average feed intake analysis, the average feed intake of test group 2 (conventional diet + zinc oxide + plant extract) and test group 3 (conventional diet + zinc oxide + β-glucan) increased by 19.55% and 1.52% compared with the control group, indicating that plant extracts can increase the feed intake of piglets. Further, the average feed intake of test group 5 is 256.66g / d, which is 32.05% higher than that of the control group. The astragalus polysaccharide in the feed additive of the present invention is replaced by soybean isoflavones (test group 4), and the average feed intake of piglets is slightly lower than that of test group 5, indicating that the feed additive provided by the present invention is the best in improving the feed intake of piglets.

[0052] From the average daily weight gain data of piglets, the performance of test group 1 is close to that of the control group, while test groups 2, 3, 4 and 5 show more significant growth advantages, with average daily weight gain increased by 26.35%, 3.97%, 38.93% and 52.92% respectively compared with the control group. However, while using zinc oxide as a feed additive to promote the growth of piglets, it is also necessary to be alert to the risk of zinc poisoning that may be caused. This side effect will undoubtedly have an adverse effect on the growth performance of piglets. To solve this problem, the present invention introduces plant extracts including astragalus polysaccharides, oregano extracts and eucommia leaf extracts and β-glucan to alleviate the negative effects of zinc oxide and further promote the healthy growth of piglets. The test results show that although plant extracts and β-glucan can alleviate the adverse effects of zinc oxide to a certain extent when used alone, the effect of the synergistic effect of the two is more significant, and the promotion effect on the growth of piglets is far beyond the reach of a single ingredient. In addition, the present invention replaces the astragalus polysaccharide in the plant extract with soy isoflavones, resulting in a decrease in the average daily weight gain of piglets compared with that of test group 5, further confirming the synergistic effect between the plant extract and β-glucan.

[0053] Feed-to-weight ratio is a key indicator for measuring feed conversion efficiency. The lower the value, the less feed the piglets consume to achieve the same weight gain. The feed-to-weight ratio of the control group was 1.74, the feed-to-weight ratio of experimental group 1 was 1.77, the feed-to-weight ratio of experimental group 2 was 1.65, the feed-to-weight ratio of experimental group 3 was 1.70, the feed-to-weight ratio of experimental group 4 was 1.62, and the feed-to-weight ratio of experimental group 5 was 1.50.

[0054] Table 3 Growth performance of piglets in each experimental group

[0055]

[0056]

[0057] 2. Analysis of diarrhea index in each experimental group

[0058] The defecation and diarrhea numbers of piglets were observed every day. The test results are shown in Table 4.

[0059] Table 4 Excretion of piglets

[0060]

[0061] As shown in Table 4, when only zinc oxide was added to the conventional diet, the diarrhea of ​​piglets was more serious. However, when zinc oxide, plant extracts and β-glucan were used in combination, the diarrhea of ​​piglets was significantly improved, indicating that the zinc oxide feed additive of the present invention can promote the growth and development of piglets while effectively reducing the incidence of diarrhea in piglets, thereby significantly improving the breeding effect.

[0062] The embodiments described above are part of the embodiments of the present invention, but not all of them. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention claimed for protection, but only represents selected embodiments of the present invention. All other embodiments obtained without creative work and related deductions and substitutions made by ordinary technicians in the field under the conditions of the concept of the present invention belong to the scope of protection of the present invention.

Claims

1. A zinc oxide feed additive suitable for piglets, characterized in that: The zinc oxide feed additive contains, by weight: 1 to 2 parts of zinc oxide, 5 to 10 parts of plant extract, and 1 to 2 parts of beta-glucan; The plant extracts are astragalus polysaccharide, oregano extract and eucommia leaf extract.

2. The zinc oxide feed additive suitable for piglets according to claim 1, characterized in that: The mass ratio of the astragalus polysaccharide, the oregano extract and the eucommia leaf extract is 1-3:2-3:2-4.

3. The zinc oxide feed additive suitable for piglets according to claim 1, characterized in that: The zinc oxide feed additive is composed of 1-2 parts of zinc oxide, 1-3 parts of astragalus polysaccharide, 2-3 parts of oregano extract, 2-4 parts of eucommia leaf extract and 1-2 parts of beta-glucan in parts by weight.

4. The zinc oxide feed additive suitable for piglets according to claim 3, characterized in that: The zinc oxide feed additive is composed of 15 parts of zinc oxide, 20 parts of astragalus polysaccharide, 30 parts of oregano extract, 20 parts of eucommia leaf extract and 15 parts of beta-glucan in parts by weight.

5. Use of the zinc oxide feed additive suitable for piglets as claimed in any one of claims 1 to 4.

6. The use according to claim 5, characterized in that: The added amount of the zinc oxide feed additive accounts for 0.8% to 1.3% of the total weight of the piglet feed.

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