一种用于热习服和热射病研究的磁性神经调控实验装置

By using the rotating magnetic field of a magnetic neuromodulation experimental device in heat acclimatization and heatstroke research, magnetic nanoparticles were used to non-invasively modulate experimental mouse neurons, solving the problem of low efficiency of invasive surgery in existing technologies and achieving the feasibility of long survival time and large-sample experiments.

CN119969282BActive Publication Date: 2026-07-17CHINESE PEOPLES LIBERATION ARMY XINJIANG MILITARY REGION GENERAL HOSPITAL

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHINESE PEOPLES LIBERATION ARMY XINJIANG MILITARY REGION GENERAL HOSPITAL
Filing Date
2025-02-20
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

In existing technologies, the surgical methods for neuronal modulation in experimental mice used in heat acclimatization and heatstroke research are invasive, and large-scale experiments are inefficient with short survival times for the mice.

Method used

A magnetic neuromodulation experimental device was used to generate a rotating magnetic field in the experimental chamber. Magnetic nanoparticles were used to non-invasively modulate the neurons of experimental mice. The magnetic field rotation was achieved by combining the magnetic field generation mechanism and the driving mechanism, thereby controlling the body temperature.

Benefits of technology

It achieves non-invasive neuronal regulation in laboratory mice, with long survival time, making it suitable for large-sample experiments and extending the monitoring time.

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Abstract

本发明提供了一种用于热习服和热射病研究的磁性神经调控实验装置,包括机架、实验舱、磁场生成机构和驱动机构。实验舱设置在机架上,磁场生成机构设置在机架上,磁场生成机构用于在实验舱内生成磁场。驱动机构用于驱动磁场生成机构旋转以实现磁场旋转。通过驱动机构驱动磁场生成机构旋转,从而在实验舱内形成旋转的磁场,该旋转磁场按照180° / s进行旋转,结合磁性纳米颗粒实现神经元调控,从而控制实验鼠体温。相较于现有技术中双光子光遗传学技术而言,可实现神经元无创调控,实验鼠存活时间长,可监测时间长,可进行大样本实验。
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