苯甲酰肼类抗肿瘤化合物及其制备方法与应用
By modifying the structure of dendritic and compressorin A4, benzoyl hydrazine compounds were synthesized, solving the problem of existing chemotherapy drugs having no differential effect on tumor and normal cells, and achieving a highly efficient inhibitory effect on human gastric cancer cells.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- JIANGSU OCEAN UNIV
- Filing Date
- 2025-01-22
- Publication Date
- 2026-07-17
AI Technical Summary
Existing chemotherapy drugs have no difference in effect on tumor and normal cells, resulting in significant side effects. It is necessary to develop anti-tumor drugs with better efficacy and fewer side effects.
Benzoylhydrazine compounds were synthesized by structural modification of romaine and compressin A4, including condensation of p-methoxybenzaldehyde with 3,4,5-trimethoxyaniline, Schiff base reduction, and condensation reaction, etc., and preferred structures such as 4-(2-benzoylhydrazine-1-carbonyl)-N-(4-methoxybenzyl)-N-(3,4,5-trimethoxyphenyl)benzamide, etc.
The synthesized benzoyl hydrazine compounds exhibit strong inhibitory activity against human gastric cancer cells (SGC-7901), with an IC50 value of 15 nM, demonstrating broad application prospects as anti-tumor drugs.
Smart Images
Figure CN119977832B_ABST