Use of acidic glycoprotein orm in the preparation of a medicament for treating sarcopenia
The drug, prepared using exogenous acidic glycoprotein ORM, solves the treatment challenge of sarcopenia, significantly improves muscle atrophy and grip strength, restores muscle mass, and is suitable for tablets, capsules, oral dosage forms, and injections.
CN120000768BActive Publication Date: 2026-06-26THE NAVAL MEDICAL UNIV OF PLA
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- THE NAVAL MEDICAL UNIV OF PLA
- Filing Date
- 2025-03-06
- Publication Date
- 2026-06-26
AI Technical Summary
Technical Problem
Current technology has not yet provided an effective treatment for sarcopenia, especially primary and secondary muscular atrophy syndromes caused by aging or systemic diseases.
Method used
Using exogenous acidic glycoprotein ORM as the sole active ingredient, tablets, capsules, oral medications, or injections are prepared to improve dexamethasone-induced sarcopenia and muscle atrophy symptoms in mice.
Benefits of technology
It significantly improved the dexamethasone-induced sarcopenia model and mouse muscle atrophy, restored muscle mass and grip strength, reduced body fat percentage, and alleviated symptoms of muscle loss.
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Smart Images
Figure CN120000768B_ABST
Abstract
The application belongs to the field of drug research and development, and particularly relates to application of an acid glycoprotein ORM in preparation of a drug for treating muscle reduction, and the application uses ORM1 knockout mice to evaluate the role of ORM in muscle reduction, and results show that glucocorticoid (dexamethasone) can induce muscle reduction, which is manifested in that the body weight of mice is reduced, the grip strength is reduced, and the skeletal muscle mass is reduced, and these indexes are more seriously reduced after ORM is knocked out, and exogenous ORM can significantly improve the cell muscle reduction model induced by dexamethasone, thereby providing a new idea for treatment of muscle reduction.
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