一种比率型光声成像探针、制备方法及应用
By preparing an albumin-zinc sulfide-indocyanine green probe, the accuracy and precision issues of copper ion detection in the brain were resolved, achieving highly sensitive copper ion ratiometric photoacoustic imaging, which is suitable for the precise detection of Alzheimer's disease.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHENZHEN INST OF ADVANCED TECH
- Filing Date
- 2023-11-23
- Publication Date
- 2026-07-17
AI Technical Summary
In existing technologies, in vivo fluorescence imaging of copper ions in the brain suffers from limited penetration depth, difficulty in crossing the blood-brain barrier, and fluorescence quenching, resulting in insufficient detection accuracy and precision, and a lack of effective copper ion ratiometric photoacoustic imaging probes.
Albumin-zinc sulfide nanoprobes were prepared using albumin as a modifying agent. Unreacted reagents were removed by ultrafiltration, and indocyanine green was added to prepare an albumin-zinc sulfide-indocyanine green probe. A copper ion-responsive ratio photoacoustic imaging probe was constructed, and the photoacoustic signal was activated by cation exchange reaction to achieve quantitative detection of copper ion ratio.
This invention provides a highly sensitive and accurate method for detecting copper ions. The probe has a near-infrared fluorescence signal, which can be traced in vivo, reducing background signal interference and improving the specificity and accuracy of detection.
Smart Images
Figure CN120022388B_ABST