Ray response type self-assembly polypeptide and hydrogel and application thereof

Abstract

The invention belongs to the field of biological medicine, and particularly relates to a ray response type self-assembly polypeptide, hydrogel and application thereof. The ray response type self-assembled polypeptide derivative hydrogel disclosed by the invention has the advantages of simple synthesis method, good biocompatibility, easiness in drug loading and the like. The hydrogel can trigger pulse type drug release through ray response, accurately regulate and control the drug release rate in a time-space controllable manner, and enhance the synergistic effect of radiotherapy and drug therapy. Due to high biological safety, long-term negative effects on a human body can be avoided, and the method has a very wide application prospect. Therefore, the ray response type polypeptide hydrogel disclosed by the invention can be widely applied to treatment of radiation-related diseases such as tumor radiotherapy combined treatment, postoperative tissue repair and regeneration, nuclear drug delivery and nuclear medicine image-guided treatment, and a more accurate and effective collaborative treatment scheme is provided.

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