Human lncRNA, biological material for inhibition, preparation and application

Abstract

The invention discloses a human lncRNA, a biological material for inhibition, a preparation and application, the human lncRNA is derived from a human chromosome Chr8p21.3 and has a nucleotide sequence as shown in SEQ ID NO.1, the biological material for inhibition and the preparation provided by the invention can effectively inhibit the expression of the lncRNA so as to inhibit adipocyte differentiation, and the human lncRNA can be used for inhibiting adipocyte differentiation. Comprising inhibition of expression quantities of differentiation related genes C / EBP alpha, C / EBP beta and FABP4 and inhibition of formation of lipid droplets. Furthermore, a biological material and a preparation for inhibiting the human lncRNA can be used for preparing medicines for treating obesity, and a new direction is provided for obesity intervention.

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