Preparation method and application of amoxicillin-loaded exosome and exosome bacteriostatic spray
The electroporation technology loads amoxicillin into the exosome, solving the problems of low bioavailability and great side effects of traditional amoxicillin preparations, and achieving accurate, continuous release and efficient treatment of drugs.
CN120227470APending Publication Date: 2025-07-01JILIN UNIVERSITY
Patent Information
- Application Number
- CN202411550317.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-01
- Publication Date
- 2025-07-01
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Figure CN120227470A_ABST
Abstract
The invention relates to the technical field of bacteriostatic drugs, in particular to a preparation method and application of an amoxicillin-loaded exosome and an exosome bacteriostatic spray. The invention provides a preparation method of an amoxicillin-loaded exosome, which comprises the following steps: mixing amoxicillin and an exosome, and introducing amoxicillin into the exosome by using an electroporation method to obtain the amoxicillin-loaded exosome. According to the present invention, the amoxicillin is uniformly and stably encapsulated in the exosome by using the electroporation technology, such that the drug loading mass ratio of the exosome to the amoxicillin is ensured to achieve 7.2-11.2%, and the accurate and continuous drug release is achieved. Meanwhile, the medicine is encapsulated, and can be released as required according to the change of an in-vivo microenvironment, so that the side effect of singly using the amoxicillin is greatly reduced, and the treatment effect is improved.
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Citation Information
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