MRNA for treating metabolic diseases, pharmaceutical composition and application

CN120242072APending Publication Date: 2025-07-04PEKING UNION MEDICAL COLLEGE HOSPITAL
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Patent Information

Application Number
CN202510173644.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-02-18
Publication Date
2025-07-04

AI Technical Summary

Technical Problem

The existing drugs for treating hyperuricemia and gout are difficult to balance the effectiveness and side effects. Traditional drugs such as allopurinol and uridase drugs have problems such as large side effects and poor treatment effects during use.

Method used

An mRNA containing a specific CDS coding region was designed and prepared into a liposome nanoparticle delivery system by optimizing the nucleotide sequence and modifying it, which is used to express uricase in the body and reduce uric acid levels in the blood.

Benefits of technology

It significantly reduces TNFα and IL-8 levels in the body, reduces inflammatory response, improves the effect of reducing uric acid, prolongs the half-life, improves bioavailability, and reduces side effects. It is suitable for a variety of patient groups.

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Abstract

The invention relates to the field of biomedicine, in particular to mRNA for treating metabolic diseases, a pharmaceutical composition and application. The mRNA comprises a CDS coding region; the CDS coding region is selected from any one of nucleotide sequences as shown in SEQ ID NO: 1-20, or one of nucleotide sequences which have codon degeneracy and at least 70% identity with any one of the nucleotide sequences as shown in SEQ ID NO: 1-20, and the prepared mRNA for treating the metabolic diseases is used for preparing medicines for treating the metabolic diseases. And the pharmaceutical composition or the medicine has remarkable clinical application potential in application of the pharmaceutical composition or the medicine for treating diseases such as hyperuricemia or gout.
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