RNF213羧基端E3结构域或其编码基因、或含有其编码基因的生物材料在制备产品中的应用
By regulating the expression level or activity of the E3 domain at the carboxyl terminus of RNF213, a product was prepared to regulate the innate immune activity and antibacterial response in poultry, solving the problem of prevention and treatment of salmonellosis and enhancing the poultry's resistance to Salmonella.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- INSTITUTE OF ANIMAL SCIENCES OF CHINESE ACADEMY OF AGRICULTURAL SCIENCES
- Filing Date
- 2025-02-27
- Publication Date
- 2026-07-17
AI Technical Summary
Current technologies cannot effectively regulate the innate immune activity and antibacterial response of poultry, making it difficult to eradicate salmonellosis through prevention and treatment, and bacterial resistance continues to develop.
By utilizing the C-terminal E3 domain of RNF213 or its encoding gene, products such as pharmaceuticals and feed additives can be prepared by regulating their expression level or activity. This can regulate the innate immune activity and antibacterial response of poultry, and enhance their resistance to Gram-negative bacteria such as Salmonella.
It significantly enhanced the innate immune activity of poultry, increased the resistance of mononuclear macrophages to Salmonella, and enhanced the levels of cellular immune factors and the activity of NF-κB, providing an effective means of preventing and treating salmonellosis.
Smart Images
Figure CN120285163B_ABST