A quick-drying, no-rinse hand sanitizer gel and method of making

Abstract

The application relates to the technical field of disinfection gels, and discloses a quick-drying no-wash hand disinfection gel and a preparation method.The disinfection gel comprises the following components in percentage by weight: 70-80% of ethanol, 0.3-0.8% of carbomer, 0.1-1% of glycerol glucoside, 0.05-0.5% of hydroxyethyl cellulose, 0.05-0.2% of triethanolamine, 1-5% of a moisturizing agent, 0.15-0.9% of an anti-allergic agent, 0.02-0.1% of a soothing agent, and the balance of water.The application can prolong the storage time of the disinfection gel, thereby prolonging the service life and maintaining the sterilization effect of the disinfection gel.

Description

Technical Field

[0001] This application relates to the technical field of hand sanitizing gels, and in particular to a quick-drying, no-rinse hand sanitizing gel and its preparation method. Background Technology

[0002] Quick-drying, no-rinse hand sanitizer gel is a portable disinfection product made with alcohol (usually 70%-80% ethanol) as the core bactericidal ingredient, combined with a gel matrix, moisturizers, and functional additives. Its emergence is inseparable from the upgrading of public health needs, especially due to its waterless and rapid sterilization characteristics, which have quickly made it an important tool for personal protection and epidemic prevention in public places.

[0003] The core advantage of quick-drying, no-rinse hand sanitizer gel lies in its balance between rapid sterilization and convenience. The alcohol component can kill 99.9% of common pathogens (such as E. coli and Staphylococcus aureus) within 30 seconds, while the gel texture avoids the fluidity issues of liquid disinfectants, making it easy to carry and use. The formulation is also constantly being improved and optimized; for example, moisturizing ingredients such as hyaluronic acid are added to alleviate the skin irritation caused by alcohol, and honeysuckle plant extract gives the product natural antibacterial and soothing effects. While these components enhance the comfort of the hand sanitizer gel, due to the volatile nature of ethanol, the ethanol concentration may decrease and the sterilization ability weakens after a certain period of storage following opening. Summary of the Invention

[0004] To improve the shelf life of quick-drying hand sanitizer gel, this application provides a quick-drying hand sanitizer gel. By using a combination of carmboside, glyceryl glucoside, hydroxyethyl cellulose, and triethanolamine in the component formulation, a more stable network structure is formed, which is less prone to molecular chain curling and has good encapsulation force for ethanol molecules. This greatly improves the shelf life of the sanitizer gel and makes it less likely for the sanitizing effect to weaken due to ethanol evaporation.

[0005] In the first aspect, this application provides a quick-drying, no-needle hand sanitizer gel, which adopts the following technical solution: A quick-drying, no-needle hand sanitizing gel, by weight percentage, comprises the following components: 70-80% ethanol, 0.3-0.8% carbomer, 0.1-1% glyceryl glucoside, 0.05-0.5% hydroxyethyl cellulose, 0.05-0.2% triethanolamine, 1-5% humectant, 0.15-0.9% anti-allergen, 0.02-0.1% soothing agent, with the balance being water.

[0006] By employing the above technical solution, carbomer, as a gel component in a disinfectant gel, can form a gel network that adsorbs and locks in moisture, providing long-lasting hydration to the skin, reducing moisture loss, and synergistically providing a certain antibacterial effect with ethanol. Furthermore, the addition of glyceryl glucoside, hydroxyethyl cellulose, and triethanolamine to the composition enhances the film-forming properties of carbomer, forming a capsule-like structure with the other components, thereby slowing down the ethanol evaporation rate. Hydroxyethyl cellulose forms a three-dimensional network structure through molecular chain entanglement and, synergistically with carbomer, improves the stability of the gel state and encapsulates ethanol molecules, thus reducing viscosity decrease and ethanol evaporation. Triethanolamine promotes the extension of carbomer chain segments, further promoting the formation of a three-dimensional network structure between carbomer and hydroxyethyl cellulose, thus better encapsulating ethanol. Therefore, the combined use of carbomer with glyceryl glucoside, hydroxyethyl cellulose, and triethanolamine not only demonstrates good compatibility in the system but also exhibits synergistic effects, forming a more stable network structure and enhancing the attraction to ethanol molecules. This reduces the likelihood of weakened bactericidal effects due to decreased ethanol content after a period of storage.

[0007] Optionally, by weight percentage, it includes the following components: 75-80% ethanol, 0.5-0.6% carbomer, 0.4-0.6% glyceryl glucoside, 0.2-0.3% hydroxyethyl cellulose, 0.1-0.15% triethanolamine, 3-4% humectant, 0.3-0.5% anti-allergen, 0.02-0.1% soothing agent, and the balance being water.

[0008] By adopting the above technical solution and further defining each component, the resulting disinfectant gel has a better effect.

[0009] Optionally, the anti-allergy agent includes bisabolol and purslane extract, wherein the weight ratio of bisabolol to purslane extract is 1:(2-10).

[0010] By adopting the above technical solutions, the penetration of moisturizing ingredients can be promoted, the sebum film can be repaired, and transepidermal water loss can be reduced. The combination of bisabolol and purslane extract can not only enhance the antibacterial and antiviral capabilities of the product, but also significantly improve the skin irritation caused by the high alcohol content formula.

[0011] Optionally, the moisturizer is selected from glycerin.

[0012] By adopting the above technical solution, the moisturizer is selected from glycerin, which can relieve skin dryness caused by ethanol and reduce degreasing irritation. In addition, glycerin can form hydrogen bonds with ethanol, which can work with other components to slow down its evaporation rate, thereby further improving the shelf life of the hand sanitizer gel.

[0013] Optionally, the soothing agent is selected from aloe vera powder.

[0014] By adopting the above technical solutions, aloe vera powder can not only enhance moisturizing and soothing effects, but also improve the adsorption capacity of ethanol through its natural polysaccharide structure, thus extending the product's shelf life.

[0015] Optionally, the mass ratio of carbomer, glycerol glucoside, hydroxyethyl cellulose, and triethanolamine is 5:5:1:1.

[0016] Optionally, by weight percentage, it may also include 0.2-0.4% allantoin.

[0017] By adopting the above technical solution, allantoin has multiple effects such as repair, moisturizing and anti-inflammation. At the same time, it can have a variety of hydrogen bond forces with ethanol, which can further synergize with other components to delay the volatilization of ethanol.

[0018] Secondly, this application provides a quick-drying, no-rinse hand sanitizer gel.

[0019] A method for preparing a quick-drying, no-rinse hand sanitizer gel includes the following steps: (1) Dissolve hydroxyethyl cellulose in a portion of water, stir under heating until dissolved, and add the remaining water to obtain a hydroxyethyl cellulose solution; (2) Under stirring conditions, carbomer is added to the hydroxyethyl cellulose solution, and after standing, it is stirred evenly to dissolve and obtain a homogeneous mixture of hydroxyethyl cellulose and carbomer. (3) Add ethanol to the container, and while stirring, add glyceryl glucoside, moisturizer, anti-allergen and soothing agent until they are mixed evenly to obtain a mixture; (4) The homogenate obtained in step (2) is filtered through a 200-400 mesh filter and added to the mixture obtained in step (3). The mixture is stirred evenly and allowed to stand for 1 hour. (5) Add the triethanolamine solution to the mixture in step (4) and stir evenly to obtain the quick-drying hand sanitizing gel.

[0020] Optionally, in step (1), the heating temperature is 70-80°C.

[0021] In summary, this application includes at least one of the following beneficial effects: 1. By combining carmbo, glycerol glucoside, hydroxyethyl cellulose and triethanolamine in the component formulation, a more stable network structure is formed, which is less prone to molecular chain curling and has a good encapsulation force for ethanol molecules, thereby greatly improving the shelf life of the disinfectant gel and making it less likely for the disinfection effect to weaken due to ethanol evaporation. 2. By using glycerin as a humectant, not only is the wetting effect of the disinfectant gel improved, but it can also work synergistically with other components through hydrogen bonding to reduce ethanol evaporation. Detailed Implementation

[0022] The present application will be further described in detail below with reference to the embodiments.

[0023] Example 1: Prepare raw materials. By weight, 100 parts of raw materials are: 70 parts of ethanol, 0.3 parts of carbomer, 0.1 parts of glyceryl glucoside, 0.05 parts of hydroxyethyl cellulose, 0.05 parts of triethanolamine, 1 part of moisturizer (selected from glycerin), 0.15 parts of anti-allergy agent (selected from bisabolol and purslane extract, with a mass ratio of bisabolol to purslane extract of 1:2), 0.02 parts of soothing agent (selected from aloe vera powder), and the remainder is purified water.

[0024] The preparation of disinfectant gel includes the following steps: (1) Add hydroxyethyl cellulose to 10% of the total water in the formula and heat to 70-80℃ to promote the dissolution of hydroxyethyl cellulose. Continue stirring. After the hydroxyethyl cellulose is dissolved, add the remaining water to obtain a hydroxyethyl cellulose solution. (2) Under stirring conditions, carbomer was added to the above hydroxyethyl cellulose solution, and after standing for 30 minutes, it was stirred until it was evenly dissolved to obtain a homogeneous mixture of hydroxyethyl cellulose and carbomer. (3) Add 95% ethanol to the reaction vessel, and while stirring, add glycerol, glyceryl glucoside, aloe vera powder, bisabolol and purslane extract until they are completely mixed. (4) The homogenate obtained in step (2) is filtered through a 200-400 mesh filter, and the filtered homogenate is added to the mixture obtained in step (3), stirred evenly, and kept standing for 1 hour to eliminate air bubbles; (5) Add a 20% triethanolamine aqueous solution to the mixture in step (4) and stir slowly until homogeneous to prepare a quick-drying hand sanitizing gel.

[0025] Example 2: Prepare raw materials. By weight, 100 parts of raw materials are: 75 parts of ethanol, 0.5 parts of carbomer, 0.4 parts of glyceryl glucoside, 0.2 parts of hydroxyethyl cellulose, 0.1 parts of triethanolamine, 3 parts of moisturizer (selected from glycerin), 0.3 parts of anti-allergen (the anti-allergen is selected from bisabolol and purslane extract, and the mass ratio of bisabolol to purslane extract is 1:10), 0.02 parts of soothing agent (selected from aloe vera powder), and the remainder is purified water.

[0026] The preparation of disinfectant gel includes the following steps: (1) Add hydroxyethyl cellulose to 10% of the total water in the formula and heat to 70-80℃ to promote the dissolution of hydroxyethyl cellulose. Continue stirring. After the hydroxyethyl cellulose is dissolved, add the remaining water to obtain a hydroxyethyl cellulose solution. (2) Under stirring conditions, carbomer was added to the above hydroxyethyl cellulose solution, and after standing for 30 minutes, it was stirred until it was evenly dissolved to obtain a homogeneous mixture of hydroxyethyl cellulose and carbomer. (3) Add 95% ethanol to the reaction vessel, and while stirring, add glycerol, glyceryl glucoside, aloe vera powder, bisabolol and purslane extract until they are completely mixed. (4) The homogenate obtained in step (2) is filtered through a 200-400 mesh filter, and the filtered homogenate is added to the mixture obtained in step (3), stirred evenly, and kept standing for 1 hour to eliminate air bubbles; (5) Add a 20% triethanolamine aqueous solution to the mixture in step (4) and stir slowly until homogeneous to prepare a quick-drying hand sanitizing gel.

[0027] Example 3: The process steps and components of this example are the same as those of Example 2, except that the amount of raw materials is different. Based on 100 parts by weight, there are 80 parts of ethanol, 0.8 parts of carbomer, 1 part of glyceryl glucoside, 0.5 parts of hydroxyethyl cellulose, 0.2 parts of triethanolamine, 5 parts of moisturizer (selected from glycerin), 0.9 parts of anti-allergy agent (the anti-allergy agent is selected from bisabolol and purslane extract, and the mass ratio of bisabolol and purslane extract is 1:10), 0.1 parts of soothing agent (selected from aloe vera powder), and the balance is purified water.

[0028] Example 4: The process steps and components of this example are the same as those of Example 2, except that the amount of raw materials is different. Based on 100 parts by weight, there are 80 parts of ethanol, 0.5 parts of carbomer, 0.6 parts of glyceryl glucoside, 0.3 parts of hydroxyethyl cellulose, 0.15 parts of triethanolamine, 4 parts of moisturizer (selected from glycerin), 0.5 parts of anti-allergen (the anti-allergen is selected from bisabolol and purslane extract, and the mass ratio of bisabolol to purslane extract is 1:10), 0.1 parts of soothing agent (selected from aloe vera powder), and the remainder is purified water.

[0029] Example 5: The process steps and components of this example are the same as those of Example 2, except that the amount of raw materials is different. Based on 100 parts by weight, there are 75 parts of ethanol, 0.5 parts of carbomer, 0.5 parts of glyceryl glucoside, 0.1 parts of hydroxyethyl cellulose, 0.1 parts of triethanolamine, 2 parts of moisturizer (selected from glycerin), 0.45 parts of anti-allergen (the anti-allergen is selected from bisabolol and purslane extract, and the mass ratio of bisabolol to purslane extract is 1:2), 0.2 parts of soothing agent (selected from aloe vera powder), and the remainder is purified water.

[0030] Example 6: This example has the same process steps and component content as Example 5, except that it also includes 0.3 parts of allantoin.

[0031] Comparative Example 1 is the same as Example 1 in terms of process steps and component content, except that an equal amount of glycerol glucoside is used instead of hydroxyethyl cellulose.

[0032] Comparative Example 2 is the same as Example 1 in terms of process steps and component content, except that an equal amount of hydroxyethyl cellulose is used to replace glycerol glucoside.

[0033] Comparative Example 3 is the same as Example 1 in terms of process steps and component content, except that an equal amount of glycerol glucoside is used to replace triethanolamine.

[0034] Performance testing: The opened product was placed in an oven at 38±1℃ for 90 days, and the active ingredient (ethanol) was tested on day 1 and day 90 by gas chromatography. The decrease rate of the active ingredient was calculated. Decrease rate = (original active ingredient concentration - post-test active ingredient concentration) / original active ingredient concentration * 100%.

[0035] The decrease rates of ethanol concentration in Examples 1-6 and Comparative Examples 1-3 are shown in the table below:

[0036] A comparison of Examples 5 and 6 shows that by adding allantoin to the components, the effective ingredient (ethanol) showed a lower decrease rate in a constant-temperature test environment. This indicates that allantoin can synergistically enhance the interaction force with ethanol molecules, thereby reducing ethanol evaporation and extending the shelf life of the disinfectant gel product. Even after 90 days of use, the ethanol content remained at a high level, thus maintaining the bactericidal and disinfecting effect.

[0037] The comparison between Example 1 and Comparative Examples 1-3 shows that hydroxyethyl cellulose, glycerol glucoside, and triethanolamine can synergistically promote the stability of ethanol molecules in the disinfectant gel, thereby greatly improving the shelf life of the disinfectant gel product after opening.

[0038] The above are all preferred embodiments of this application and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A quick-drying, no-rinse hand sanitizer gel, characterized in that: By weight percentage, it consists of the following components: 75% ethanol, 0.5% carbomer, 0.5% glyceryl glucoside, 0.1% hydroxyethyl cellulose, 0.1% triethanolamine, 2% humectant, 0.45% anti-allergen, 0.2% soothing agent, and the balance being water; the humectant is glycerin; the soothing agent is aloe vera powder. The anti-allergy agent is bisabolol and purslane extract, and the weight ratio of bisabolol to purslane extract is 1:

2.

2. The method for preparing a quick-drying, no-rinse hand sanitizer gel according to claim 1, characterized in that: Includes the following steps: (1) Dissolve hydroxyethyl cellulose in a portion of water, stir under heating until dissolved, and add the remaining water to obtain a hydroxyethyl cellulose solution; (2) Add carbomer to the hydroxyethyl cellulose solution under stirring, and stir until dissolved after standing to obtain a homogeneous mixture of hydroxyethyl cellulose and carbomer; (3) Add ethanol to a container, and add glycerol glucoside, moisturizer, anti-allergen and soothing agent while stirring until mixed evenly to obtain a mixture; (4) Filter the homogeneous mixture obtained in step (2) through a 200-400 mesh filter and add it to the mixture obtained in step (3), stir evenly, and keep it standing for 1 hour; (5) Add triethanolamine solution to the mixture in step (4) and stir evenly to obtain the quick-drying hand sanitizing gel.

3. The method for preparing a quick-drying, no-rinse hand sanitizer gel according to claim 2, characterized in that: In step (1), the heating temperature is 70-80℃.

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