Stable gold nanoparticles and methods of making and using the same

By modifying gold nanoparticles with hairpin DNA, the problem of poor stability of gold nanoparticles was solved, and the stability under extreme conditions was improved, making them suitable for biological detection and drug delivery.

CN120347203BActive Publication Date: 2026-02-13HENAN UNIVERSITY
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Patent Information

Application Number
CN202510487507.2
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-04-17
Publication Date
2026-02-13
Estimated Expiration
2045-04-17

AI Technical Summary

Technical Problem

Gold nanoparticles suffer from poor stability in practical applications, especially under extreme conditions where they are prone to aggregation or oxidation, affecting their performance and function. Existing modification methods, such as PEG modification, have limitations in application and are cumbersome in procedure.

Method used

Gold nanoparticles with enhanced stability were prepared by using hairpin DNA modification, by designing specific nucleotide sequences such as SEQ ID NO.1, and attaching 1 to 10 T bases and thiol groups to the 5' end, combined with a stepwise addition of salt solution.

Benefits of technology

It significantly improves the stability of gold nanoparticles, enabling them to withstand strong acid environments (above pH 2) and salt resistance (able to withstand ionic strengths above 100 mM Mg2+, making them suitable for biosensoring and drug delivery).

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Abstract

The application provides a gold nanoparticle with enhanced stability and a preparation method and application thereof, and belongs to the technical field of gold nanoparticles. The gold nanoparticle with enhanced stability provided by the application is modified on the surface with a hairpin DNA; the nucleotide sequence of the hairpin DNA is shown as SEQ ID NO. 1. The gold nanoparticle of the application is modified by the hairpin DNA, and the stability is significantly improved, specifically including tolerance to a strong acid environment, stable existence in an environment with a pH of 2 or more, and a substantial improvement in salt tolerance, tolerance to 100 mM Mg 2+ of the above ion strength.
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