一种研究不同细胞器间分子互作的方法及其应用
By extracting and identifying proteins and lipids from organelle samples, and combining data processing and separation methods, the problem of the inability to fully analyze molecular interactions between organelles in existing technologies has been solved. This has enabled efficient organelle separation and construction of molecular interaction networks, revealing key molecular connections between organelles.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SUN YAT SEN UNIV
- Filing Date
- 2025-03-04
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies are insufficient to fully analyze the dynamic molecular interaction networks among various organelles within cells, and methods for parallel separation of high-purity organelles are not yet perfect.
An apparatus and method are employed, including the extraction and identification of proteins and lipids from organelle samples, the preprocessing of raw proteomic and lipidomic characterization data, dimensionality reduction clustering and correlation analysis, the construction of molecular interaction networks among organelles, and the efficient separation of organelles through steps such as density gradient centrifugation.
This method enables precise research on molecular interactions between different organelles, constructs a subcellular protein-lipid molecular interaction network, and identifies key molecules involved in organelle interactions. Furthermore, the isolated organelles are highly pure, and the method is simple and time-efficient.
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