Tissue highly adhesive poly-beta urethane, drug-loaded nanoparticles, and methods of making and using the same
CN120383728BActive Publication Date: 2026-08-28SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
Patent Information
- Application Number
- CN202510556066.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2025-04-29
- Publication Date
- 2026-08-28
- Estimated Expiration
- 2045-04-29
AI Technical Summary
Technical Problem
[0003]尽管这些纳米递送系统在疾病治疗方面取得了一定进展，但在靶向黏附持久性上仍存在明显不足，其在胃肠道蠕动、消化液冲刷及黏液层动态更新的复杂环境下，极易发生脱附，导致纳米载体无法在病变部位持续发挥作用
Benefits of technology
[0035]本发明通过在二丙烯酸酯类化合物的共聚主链上引入多巴胺和缩硫酮键的结构单元，制备得到了一种新型的聚β氨酯，该聚β氨酯具有很好的胃黏膜黏附和ROS响应性能。
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Figure CN120383728B_ABST
Abstract
The present application relates to a kind of tissue high-adhesion poly beta urethane, drug-loaded nanoparticle and its preparation method and application.The poly beta urethane is copolymerized by diacrylate compound and amino-containing compound;The diacrylate compound is selected from one or more of the compounds shown in formula (I-1) and (I-2) or its stereoisomer, and at least one diacrylate compound is selected from the compound shown in formula (I-2);The amino-containing compound is selected from one or more of the compounds shown in formula (II).The poly beta urethane can target drug delivery to the lesion site for treating gastrointestinal oxidative stress-related diseases (such as gastric ulcer), and can release therapeutic drug in response to the lesion site, while having good gastric mucosal adhesion capacity, can improve local drug concentration, thereby enhancing the therapeutic targeting and efficacy persistence of drug, enhancing the treatment effect.
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Citation Information
Patent Citations
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