一种快速可控的大批量金纳米棒包硅材料制备方法与应用

By employing low-temperature freezing and ultrasonic processes, and combining thiol molecules SH-PEG with gold nanoparticles to form stable covalent bonds, rapid and controllable preparation of silicon-coated gold nanorods was achieved. This solved the problems of long preparation time and low yield in existing technologies, and improved the uniformity and stability of the materials.

CN120394890BActive Publication Date: 2026-07-17XI AN JIAOTONG UNIV
View PDF 1 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
XI AN JIAOTONG UNIV
Filing Date
2025-04-29
Publication Date
2026-07-17

Smart Images

  • Figure CN120394890B_ABST
    Figure CN120394890B_ABST
Patent Text Reader

Abstract

本发明公开了一种快速可控的大批量金纳米棒包硅材料制备方法与应用，属于生物医学材料技术领域。本发明通过低温冷冻结合超声工艺实现高效制备，具体步骤包括：首先采用种子介导生长法，通过化学还原制备AuNR溶液；然后利用SH‑PEG5k‑X修饰AuNR，经冷冻‑解冻复溶形成AuNR@PEG；最后在超声辅助下依次加入氨水‑异丙醇和TEOS‑异丙醇溶液，实现均匀包硅，制得PEG‑AuNR@SiO2，即所述金纳米棒包硅材料。该方法通过超声空化效应促进反应物分散与混合，3小时内可完成10 mg级制备，产物浓度达3.18×10‑6mol / mL，且包覆层均匀性高，所得材料在病原体检测等领域具有应用潜力，解决了传统方法速度慢、产物一致性差等瓶颈问题。
Need to check novelty before this filing date? Find Prior Art