Multifunctional nano-composite hydrogel for repairing oral mucosa as well as preparation method and application of multifunctional nano-composite hydrogel

CN120420263APending Publication Date: 2025-08-05HOSPITAL OF STOMATOLOGY SUN YAT SEN UNIV +1
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Patent Information

Application Number
CN202510567584.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-04-30
Publication Date
2025-08-05

AI Technical Summary

Technical Problem

Existing oral mucosal repair materials have poor adhesion and single functions in humid environments, difficult to balance mechanical properties and biocompatibility, and there is a risk of drug side effects and bacterial disturbance, making it difficult to achieve long-term adhesion and multifunctional synergistic effects in dynamic humid environments.

Method used

Multifunctional nanocomposite hydrogel is adopted to cross-link the cross-linking of hydrogen-tungsten bronze nanoparticles, sulfonate betaine-type zwitterionic monomers and crosslinking agent catechol modified methacrylylated chitosan and methacrylylated silk fibroin to form a multi-component synergistic adhesion mechanism, combined with temperature responsiveness to release highly reducing atomic hydrogen, achieving synergistic optimization of wet adhesion, mechanical properties and biological functions.

Benefits of technology

Achieve long-lasting and reliable interface adhesion in a dynamic and humid environment, providing mechanical strength and anti-fouling properties, promoting oral mucosal defect repair, maintaining oral microecological balance, and reducing drug side effects.

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Abstract

The invention relates to the technical field of oral mucosa repair materials, and discloses multifunctional nano-composite hydrogel for oral mucosa repair and a preparation method and application of the multifunctional nano-composite hydrogel for oral mucosa repair. Then adding sulfobetaine type zwitterionic monomer (such as SBMA) with an olefin skeleton, catechol modified methacrylated chitosan (CMC) and methacrylated silk fibroin (SilMA), and crosslinking under the action of a photoinitiator to obtain the multifunctional nano composite hydrogel. The invention innovatively develops a multifunctional nano-composite hydrogel (SCS (at) H) system, and systematically realizes collaborative optimization of wet adhesion, mechanical properties and biological functions through a molecular design and material compounding strategy; the hydrogel is stably adhered in a dynamic moist oral environment, protects the wound surface of an oral mucosa from being polluted, exerts excellent antioxidant capacity in a complex inflammation environment, and effectively promotes oral mucosa defect repair.
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