An oil-control anti-dandruff, anti-hair loss shampoo composition, its preparation method and application

Abstract

The present application provides an oil-control and dandruff-removing, hair-loss-preventing hair-care composition, a preparation method and application thereof, and belongs to the technical field of cosmetics. The composition comprises the following components in percentage by weight: hair conditioner 4-10%, humectant 1-5%, thickening agent 1-3%, surfactant 15-25%, hair-loss-preventing agent 0.2-0.6%, dandruff-removing agent 0.1-0.5%, preservative 0.5-1%, fragrance 0.3-0.6%, pH regulator 0.1-0.3%, colorant 0.02-0.05%, and water in the remainder. The present application can improve hair quality and regulate scalp microecology by using multiple hair conditioners and surfactants, thereby achieving the effects of oil control, hair loss prevention and hair strengthening.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically relating to an oil-controlling, dandruff-removing, anti-hair loss and hair-strengthening shampoo composition, its preparation method and application. Background Technology

[0002] With the accelerated pace of life and increasing work intensity, hair loss diseases such as androgenetic alopecia (seborrheic alopecia) and alopecia areata are on the rise, and are showing a trend towards affecting younger people. This type of hair loss affects appearance and aesthetics, and can easily cause patients significant mental stress and psychological burden, thus seriously impacting their quality of life. In the treatment of hair loss, commonly used Western medicines include minoxidil and finasteride, but both drugs are prone to relapse after discontinuation and can cause side effects such as skin irritation, scalp itching, hirsutism on the face and hands, dizziness, anorexia, and tachycardia. In addition, while hair transplantation has some therapeutic effect, its clinical application is limited by the large surgical trauma, high cost, and the need for multiple surgeries. The effects of non-drug treatments such as acupuncture are also not ideal. In recent years, there have been increasing research reports on the use of plant extracts, such as traditional Chinese medicine, to treat hair loss. These plant-derived ingredients are relatively safe, effective, and convenient to use. Animal experiments have found that astragalus, fleeceflower root, privet fruit, and dodder seed, used alone or in combination, can stimulate the growth of hair follicles in cultured mice, increase the number of hair follicles, and accelerate hair regeneration. Clinical studies have also found that a hair loss prevention and hair growth tonic composed of traditional Chinese herbs such as Platycladus orientalis leaves, Polygonum multiflorum, Ligustrum lucidum, Ligusticum chuanxiong, and Cuscuta chinensis can significantly promote hair growth in patients with hair loss. Therefore, this article summarizes recent domestic and international research findings on the role of plant extracts in hair growth and development, and outlines the regulatory mechanisms of plant extracts on hair follicle cell signaling pathways, aiming to provide a theoretical basis for the mechanism of action of plant extracts in hair growth and development and the development of clinical hair loss treatment agents.

[0003] Dihydrotestosterone (DHT), a metabolite of testosterone, plays a crucial role in androgenetic alopecia. Patients with androgenetic alopecia have higher levels of DHT in their scalp and serum, as well as higher levels and activity of 5α-reductase, compared to the general population. Their hair follicles also exhibit an increased ability to convert testosterone to DHT. Since 5α-reductase in hair follicles mediates the conversion of testosterone to DHT, the use of 5α-reductase inhibitors such as finasteride can prolong the anagen phase of hair follicles, prevent hair loss, and promote hair growth. Animal studies in mice have shown that ginseng (Panax ginseng CAMeyer) extract and privet (Ligustrum lucidum Ait.) alcohol extract can also inhibit 5α-reductase activity, reduce DHT levels in skin tissue, and promote hair growth. In addition, plant extracts such as fig (Ficus carica Linn.), rosemary (Rosmarinus officinalis), Ganoderma lucidum, Polygonum multiflorum, arborvitae leaf (Cacumen platycladi), and Cynomorium songaricum also have inhibitory effects on 5α-reductase, and therefore have great development potential in preventing hair loss and promoting hair growth.

[0004] For example, Chinese patent CN110025775A discloses a mild hair-strengthening and anti-hair loss essence and its preparation method. The mild hair-strengthening and anti-hair loss essence includes the following raw materials: water, ethanol, Polygonum multiflorum extract, glycerin, Angelica sinensis extract, aloe vera extract, ginseng extract, tea polyphenols, corn gluten amino acids, vitamin H, folic acid, vitamin B3, pantothenic acid, vitamin B6, vitamin B2, vitamin B1, yeast polypeptides, cysteine, sodium benzoate, potassium sorbate, citric acid, linoleic acid, xylanase, and hydra extract. This invention utilizes extracts of Polygonum multiflorum, Angelica sinensis, Aloe vera, and ginseng as traditional Chinese medicine ingredients in a shampoo essence. Licorice nourishes and invigorates blood, clears the meridians; ginseng dispels wind and dampness, invigorates blood, clears the meridians, and promotes hair growth; Polygonum multiflorum promotes local blood circulation and nourishes hair; Angelica sinensis tonifies qi and strengthens yang; and Aloe vera promotes scalp blood circulation and metabolism, nourishes the hair papilla, promotes the recovery of damaged or infected scalp, reduces oil secretion in oily hair, and promotes new hair regeneration. However, research has found that simply adding the above-mentioned traditional Chinese medicine components is insufficient to meet the required levels of hair loss prevention and hair growth promotion; linoleic acid, xylanase, and hydroid extract need to be added to achieve a synergistic effect.

[0005] For example, Chinese patent CN118662418A discloses a natural plant extract composition for preventing hair loss and strengthening hair. Through the synergistic effect of seven plant extracts—including St. John's wort extract, Guaiac extract, Thunbergia odorifera pericarp extract, mango leaf extract, Polygonum multiflorum extract, Platycladus orientalis leaf extract, and ginger extract—it effectively inhibits 5α-reductase, which causes seborrheic alopecia, and major microorganisms such as Malassezia furfur, Propionibacterium acnes, and Staphylococcus aureus, thereby reducing the probability of seborrheic alopecia. The beneficial components in the seven plant extracts promote blood circulation and regulate scalp sebum secretion, which can promote hair growth and improve the scalp environment. In addition, mango leaf extract and Polygonum multiflorum extract are rich in vitamins and nutrients, which can nourish the hair, enhance its elasticity and shine, and reduce hair breakage and loss. However, this patent does not study its hair-strengthening effect; therefore, the hair-strengthening effect of the aforementioned natural plant extract composition cannot be determined.

[0006] Furthermore, existing literature, "Analysis and Development of Anti-Hair Loss Shampoo Formula Ingredients, Perfect (Guangdong) Daily Necessities Co., Ltd., Lin Xiaofeng, Zhongshan, Guangdong, 528400," discloses that the following herbs in traditional Chinese medicine all have hair-care effects: raw arborvitae leaves, Polygonum multiflorum, raw ginseng, soapberry, ginger, Eclipta prostrata, Clematis chinensis, and Ligustrum lucidum. Raw arborvitae leaves are commonly used to treat dandruff and itchy scalp. Polygonum multiflorum nourishes the liver and kidneys and darkens hair, enhancing its elasticity and shine. Raw ginseng moisturizes hair, increasing its softness and shine, and helps improve dry hair. Soapberry effectively removes oil and dirt from hair and also has anti-inflammatory and antipruritic effects. Ginger promotes scalp blood circulation, enhances hair nutrition, and helps prevent hair loss and dryness. Eclipta prostrata nourishes hair and repairs hair cuticles, and is often used to treat dry and frizzy hair. Clematis chinensis has the effects of clearing heat and detoxifying, dispelling wind and relieving itching, and can improve problems such as dandruff and itchy scalp. Ligustrum lucidum has the effects of nourishing the liver and kidneys and darkening hair, increasing hair elasticity and shine, and helping to prevent dry hair and hair loss. The addition of these ingredients helps to improve the hair care effect of the shampoo, increase product quality, and is suitable as a formula ingredient in shampoo preparation.

[0007] Furthermore, herbal plant extracts have advantages such as convenient sourcing, simple processing, and low price. They also have good compatibility with many cosmetic raw materials. These plant extracts all possess antioxidant and / or anti-inflammatory and antibacterial effects. For example, extracts from rosemary, Ganoderma lucidum, ginseng, privet fruit, Cynomorium songaricum, fig, Polygonum multiflorum, and Platycladus orientalis can promote hair growth by inhibiting 5α-reductase, and have become a leading source of research for anti-hair loss and hair growth preparations. Existing research has proven that various plant extracts or their active ingredients have significant anti-hair loss and hair growth effects with few side effects. Meanwhile, compound herbal anti-hair loss cosmetics such as hair-nourishing essences, herbal hair growth liquids, and anti-hair loss and hair growth tonics made by combining ginseng, angelica, Polygonum multiflorum, and other plant extracts have gained social recognition for their efficacy and have good development prospects.

[0008] For example, prior patent CN118121523A discloses a hair growth and hair darkening effect essence composition, its preparation method, and its application. The essence composition, by weight percentage, comprises the following components: 2-5% plant extracts; 0.2-0.8% moisturizer; 0.4-1.0% conditioning agent; 0.5-0.8% preservative; 0.2-0.4% antioxidant; and water as the balance. This application uses a mixture of rice bran extract, ginger root extract, ginseng root extract, kelp extract, grapefruit seed extract, and centella asiatica extract. The invention describes a compound made from plant extracts, with a controlled mass ratio of 1-2:1-2:1-2:1-2:0.5-0.9:0.2-0.5. By controlling the specific components and mass ratios of the plant extracts, moisturizers, and conditioning agents, the invention aims to achieve better moisturizing, hair growth, and hair darkening effects in the serum composition. In terms of moisturizing, it locks in moisture for deeper hydration; in terms of hair growth, it nourishes and repairs hair follicles, stimulating their growth; and in terms of hair darkening, it effectively activates tyrosinase activity, promoting melanin production. However, this patent does not address oil control effects.

[0009] While existing technologies disclose that various plant extracts have the effects of preventing hair loss, relieving itching, nourishing, and reducing inflammation, some studies lack quality control, statutory toxicological safety evaluation, and precise evaluation of the components of plant extracts, and there are no studies on related hair strengthening effects.

[0010] Therefore, it is necessary to develop a hair care composition with high safety and good hair loss prevention and hair strengthening effects, so as to provide more complete and accurate evidence for the effects of plant extracts on hair loss and hair strengthening. Summary of the Invention

[0011] In view of the shortcomings of the existing technology, the present invention aims to provide a shampoo composition with oil control, dandruff removal and anti-hair loss and hair strengthening effects, its preparation method and application.

[0012] To achieve the above objectives, the present invention adopts the following technical solution:

[0013] A shampoo composition for oil control, dandruff removal, and hair loss prevention comprises the following components by weight percentage: 4-10% hair conditioning agent, 1-5% moisturizer, 1-3% thickener, 15-25% surfactant, 0.2-0.6% hair loss prevention agent, 0.1-0.5% dandruff remover, 0.5-1% preservative, 0.3-0.6% fragrance, 0.1-0.3% pH adjuster, 0.02-0.05% colorant, and the balance being water.

[0014] Preferably, the oil-controlling, dandruff-removing, and hair-strengthening shampoo composition comprises, by weight percentage, the following components: 6-8% hair conditioning agent, 2-4% moisturizer, 1.5-2.5% thickener, 20-25% surfactant, 0.3-0.5% hair-loss-preventing agent, 0.2-0.4% dandruff-removing agent, 0.7-0.9% preservative, 0.4-0.5% fragrance, 0.15-0.25% pH adjuster, 0.03-0.04% colorant, and the balance being water.

[0015] As some preferred embodiments, the hair conditioning agent is present in a weight percentage of 4%, 5%, 6%, 7%, 8%, 9%, or 10%.

[0016] As some preferred embodiments, the humectant is present in a weight percentage of 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, or 5%.

[0017] As some preferred embodiments, the thickener is 1%, 1.5%, 2%, 2.5% or 3% by weight.

[0018] As some preferred embodiments, the surfactant is present in a weight percentage of 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, or 25%.

[0019] As some preferred embodiments, the hair loss prevention agent is present in a weight percentage of 0.2%, 0.3%, 0.4%, 0.5%, or 0.6%.

[0020] As some preferred embodiments, the dandruff-removing agent is present in a weight percentage of 0.1%, 0.2%, 0.3%, 0.4%, or 0.5%.

[0021] As some preferred embodiments, the preservative is present in a weight percentage of 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1.0%.

[0022] As some preferred embodiments, the fragrance agent is present in a weight percentage of 0.3%, 0.4%, 0.5%, or 0.6%.

[0023] As some preferred embodiments, the pH adjuster is present in a weight percentage of 0.1%, 0.15%, 0.2%, 0.25%, or 0.3%.

[0024] As some preferred embodiments, the colorant is present in a weight percentage of 0.02%, 0.03%, 0.04%, or 0.05%.

[0025] in,

[0026] The hair conditioning agent includes hair conditioning agent 1;

[0027] The hair conditioning agent 1 mentioned is one or more of the following: ginger root extract, ginseng root extract, kelp extract, grapefruit seed extract, centella asiatica extract, and rice bran extract.

[0028] Preferably, the hair conditioning agent 1 is a mixture of ginger (ZINGIBER OFFICINALE) root extract, ginseng (PANAXGINSENG) root extract, kelp (LAMINARIA JAPONICA) extract, grapefruit (CITRUS GRANDIS) seed extract, centella asiatica (CENTELLA SATICA) extract and rice bran (ORYZASATIVA) extract.

[0029] More preferably, the hair conditioning agent 1 is purchased from Guangzhou Huayue Medical Aesthetics Research Institute, and its trade name is HYFTGF003.

[0030] The hair conditioning agent also includes hair conditioning agent 2;

[0031] The hair conditioning agent 2 includes one or more of polydimethylsiloxane alcohol, TEA salt of dodecylbenzenesulfonate, and lauryl alcohol polyether-23;

[0032] Preferably, the hair conditioner 2 is a mixture of polydimethylsiloxane alcohol, TEA salt of dodecylbenzenesulfonate and lauryl alcohol polyether-23.

[0033] More preferably, the mass ratio of the polydimethylsiloxane alcohol, TEA salt of dodecylbenzenesulfonate, and lauryl alcohol polyether-23 is 15:1:1.

[0034] More preferably, the hair conditioner 2 is purchased from Guangzhou Boyu Biotechnology Research Co., Ltd., and its trade name is BY6119E.

[0035] The hair conditioning agent also includes hair conditioning agent 3;

[0036] The hair conditioning agent 3 is disodium azelate;

[0037] Preferably, the hair conditioning agent 3 is purchased from Guangzhou Huayue Medical Aesthetics Research Institute, and its trade name is HYDA01.

[0038] The hair conditioning agent also includes hair conditioning agent 4;

[0039] The hair conditioning agent 4 is stearamidopropyl dimethylamine;

[0040] Preferably, the hair conditioner 4 is purchased from Shanghai Zhongxiang Fine Chemical Co., Ltd., and its trade name is S18.

[0041] The hair conditioning agent also includes hair conditioning agent 5;

[0042] The hair conditioning agent 5 is guar gum hydroxypropyltrimethylammonium chloride;

[0043] Preferably, the hair conditioner 5 is purchased from Jingkun Oilfield Chemical Technology Co., Ltd., and its trade name is cationic guar gum JK 140E.

[0044] The hair conditioning agent also includes hair conditioning agent 6;

[0045] The hair conditioning agent 6 is pyridoxine hydrochloride;

[0046] Preferably, the hair conditioner 6 is purchased from DSM Nutritional Products Ltd., under the trade name Pyridoxine Hydrochloride.

[0047] The hair conditioning agent also includes hair conditioning agent 7;

[0048] The hair conditioning agent 7 is trihydroxystearin;

[0049] Preferably, the hair conditioner 7 is purchased from Ambuja Solvex Pvt.LTD., under the trade name THS.

[0050] The hair conditioning agent also includes hair conditioning agent 8, which is polyquaternium-10;

[0051] Preferably, the hair conditioner 8 is purchased from Guangzhou Haoshun Industrial Co., Ltd., and its trade name is [trade name missing].

[0052] As some preferred embodiments, the hair conditioner is a mixture of hair conditioner 1, hair conditioner 2, hair conditioner 3, hair conditioner 4, hair conditioner 5, hair conditioner 6, hair conditioner 7 and hair conditioner 8.

[0053] Preferably, the mass ratio of hair conditioner 1, hair conditioner 2, hair conditioner 3, hair conditioner 4, hair conditioner 5, hair conditioner 6, hair conditioner 7 and hair conditioner 8 is 2-5:1-2:0.5-1.0:0.2-0.5:0.2-0.5:0.1-0.3:0.1-0.2:0.1-0.2;

[0054] More preferably, the mass ratio of hair conditioner 1, hair conditioner 2, hair conditioner 3, hair conditioner 4, hair conditioner 5, hair conditioner 6, hair conditioner 7 and hair conditioner 8 is 3-4:1.5-1.8:0.6-0.8:0.3-0.4:0.3-0.4:0.2-0.3:0.15-0.2:0.15-0.2;

[0055] More preferably, the mass ratio of hair conditioner 1, hair conditioner 2, hair conditioner 3, hair conditioner 4, hair conditioner 5, hair conditioner 6, hair conditioner 7 and hair conditioner 8 is 3:1.7:0.8:0.3:0.3:0.25:0.15:0.15.

[0056] The humectant mentioned is polyquaternium-7;

[0057] Preferably, the moisturizer is purchased from Guangzhou Xingye Technology Co., Ltd., and its trade name is Ucecon M550(A).

[0058] The thickener includes thickener 1;

[0059] The thickener 1 is selected from cocamide MEA and / or glycerin;

[0060] Preferably, the thickener 1 is a mixture of cocamide MEA and glycerin;

[0061] More preferably, the mass ratio of cocoamide MEA to glycerin is 9:1;

[0062] More preferably, the thickener 1 is purchased from Guangdong Keyu New Materials Co., Ltd., and its trade name is KY-CMEA.

[0063] The thickener includes thickener 2;

[0064] The thickener 2 is sodium chloride;

[0065] Preferably, the thickener 2 is purchased from Golmud Shengfu Salt Industry Co., Ltd.

[0066] As some preferred embodiments, the mass ratio of thickener 1 to thickener 2 is 10-15:5-8;

[0067] Preferably, the mass ratio of thickener 1 to thickener 2 is 11-14:6-7;

[0068] More preferably, the mass ratio of thickener 1 to thickener 2 is 12:7.

[0069] The surfactant mentioned includes surfactant 1;

[0070] The surfactant 1 is sodium lauryl ether sulfate;

[0071] Preferably, the surfactant 1 is purchased from Hunan Lichen Aowei Industrial Co., Ltd., and its trade name is RSAWESB70 / ZA.

[0072] The surfactant mentioned includes surfactant 2;

[0073] Preferably, the surfactant 2 is ammonium lauryl sulfate;

[0074] More preferably, the surfactant 2 is purchased from Hunan Lichen Aowei Industrial Co., Ltd., and its trade name is RSAWAL70 / ZA.

[0075] As some preferred embodiments, the surfactant is a mixture of surfactant 1 and surfactant 2;

[0076] Preferably, the mass ratio of surfactant 1 to surfactant 2 is 10-20:3-5;

[0077] More preferably, the mass ratio of surfactant 1 to surfactant 2 is 12-18:3.5-4.5;

[0078] More preferably, the mass ratio of surfactant 1 to surfactant 2 is 12-18:4;

[0079] More preferably, the mass ratio of surfactant 1 to surfactant 2 is 15:4.

[0080] The hair loss prevention agent mentioned is an extract of Thuja orientalis leaves;

[0081] Preferably, the Thuja orientalis leaf extract was purchased from Guangzhou Ganabio Technology Co., Ltd.

[0082] The dandruff remover is pyrrolidone ethanolamine salt;

[0083] Preferably, the pyrrolidone ethanolamine salt is purchased from Shanghai Huanqiu Industrial Development Co., Ltd., and its trade name is OCT.

[0084] The preservative is a mixture of phenoxyethanol and sodium benzoate;

[0085] Preferably, the preservatives are all purchased from Guangdong Dimei New Materials Technology Co., Ltd.

[0086] The fragrance mentioned is a commonly used fragrance in the cosmetics industry.

[0087] The pH adjuster is a mixture of citric acid and arginine.

[0088] The colorant is caramel color, purchased from Shandong Aipu Food Industry Co., Ltd.

[0089] As a preferred embodiment, the oil-controlling, dandruff-removing, anti-hair loss, and hair-strengthening shampoo composition comprises, by weight percentage, the following components: 6.65% hair conditioning agent, 2% moisturizer, 1.9% thickener, 19% surfactant, 0.4% anti-hair loss agent, 0.3% dandruff remover, 0.9% preservative, 0.5% fragrance, 0.204% pH adjuster, 0.04% colorant, and the balance being water.

[0090] As a more preferred embodiment, the oil-controlling, dandruff-removing, anti-hair loss, and hair-strengthening shampoo composition comprises the following components by weight percentage:

[0091] HYFTGF003 3%; BY6119E 1.7%; HYDA01 0.8%; S18 0.3%; cationic guar gum JK140E 0.3%; pyridoxine hydrochloride 0.25%; trihydroxystearin 0.15%; 0.15%; Ucecon M550 2%; KY-CMEA 1.2%; Sodium chloride 0.7%; Sodium lauryl ether sulfate 15%; Ammonium lauryl sulfate 4%; Thuja orientalis leaf extract 0.4%; Piroctone ketone ethanolamine salt 0.3%; Phenoxyethanol 0.5%; Sodium benzoate 0.4%; Fragrance 0.5%; Citric acid 0.2%; Arginine 0.004%; Caramel color 0.04%; and water balance.

[0092] The present invention also provides a method for preparing the above-mentioned oil-controlling, dandruff-removing, anti-hair loss and hair-strengthening shampoo composition, comprising the following steps:

[0093] (1) Put water with a total water content of 90% and surfactant into a mixing pot, and heat it to 80-85℃ while stirring until the raw materials are completely dissolved to obtain mixture 1;

[0094] (2) Mix thickener 1 and hair conditioner 7, heat to 85°C and stir until dissolved and transparent. Then add hair conditioner 4 and homogenize for 3 minutes at a speed of 45 rpm. Then keep warm for 15 minutes until all the raw materials are dissolved to obtain mixture 2.

[0095] (3) Add hair conditioner 5 and citric acid to water with a total water content of 6% and disperse until there are no lumps. Then homogenize for 3 minutes at a homogenization speed of 45 rpm. Continue stirring at a constant temperature of 85°C for 30 minutes. Then cool down to below 40°C to obtain mixture 3.

[0096] (4) After mixing and dispersing the pyrrolidone ethanolamine salt and the remaining water, add the remaining raw materials in sequence and homogenize for 3 minutes at a homogenization speed of 45 rpm. Stir until there are no solid particles to obtain mixture 4.

[0097] (5) Under the condition of keeping warm at 85°C, add mixture 2 to mixture 1 and stir evenly, then add mixture 3 and stir evenly, then add mixture 4 and continue stirring until evenly mixed, and cool to room temperature to obtain the oil-controlling, dandruff-removing, hair loss-preventing and hair-strengthening shampoo composition.

[0098] The present invention also provides the application of the above-mentioned oil-controlling, dandruff-removing, anti-hair loss and hair-strengthening shampoo composition in the preparation of shampoo products with oil-controlling, dandruff-removing, anti-hair loss and hair-strengthening properties.

[0099] The hair care product mentioned is shampoo, hair lotion, or hair cream.

[0100] A shampoo comprising the above-mentioned oil-controlling, dandruff-removing, anti-hair loss and hair-strengthening shampoo composition and excipients used in preparing the shampoo.

[0101] A shampoo comprising the above-mentioned oil-controlling, dandruff-removing, anti-hair loss and hair-strengthening shampoo composition and excipients used in preparing the shampoo.

[0102] A shampoo includes the above-mentioned oil-controlling, dandruff-removing, anti-hair loss and hair-strengthening shampoo composition and excipients used in preparing the shampoo.

[0103] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0104] (1) This invention uses a variety of hair conditioning agents:

[0105] For example, a mixture of ginger (ZINGIBER OFFICINALE) root extract, ginseng (PANAX GINSENG) root extract, kelp (LAMINARIA JAPONICA) extract, grapefruit (CITRUS GRANDIS) seed extract, centella asiatica (CENTELLA SATICA) extract, and rice bran (ORYZASATIVA) extract can be used as a hair conditioning agent 1.

[0106] in,

[0107] Ginger (ZINGIBER OFFICINALE) root extract: It can inhibit Malassezia activity, reduce scalp inflammation and regulate sebaceous gland secretion, thereby improving the scalp environment; it has strong antioxidant properties, which help protect hair from free radical damage, enhance hair shine and improve hair's resistance to breakage; its active ingredients can stimulate the scalp, promote blood circulation and help improve the nutrient supply to hair follicles.

[0108] Ginseng (PANAX GINSENG) root extract: can increase the dilation of capillaries in the scalp, thereby providing more nutrients to the hair and enhancing its resilience; it helps improve blood circulation in the scalp, promotes the health of hair follicles, and thus reduces hair loss and breakage; by promoting the health of hair follicles, ginseng root extract can enhance the health of hair roots and reduce hair problems caused by malnutrition or poor blood circulation.

[0109] Kelp (Laminaria japonica) extract: It has antioxidant and anti-aging effects; it can inhibit the generation of oxygen free radicals, thereby slowing down the aging process of skin and hair, maintaining the health of scalp and hair, delaying scalp aging, and reducing fine lines and sagging.

[0110] Grapefruit (Citrus grandis) seed extract: Rich in B vitamins, protein and other trace elements, it can provide ample nourishment for hair, prevent hair loss, and promote healthy hair growth; its nutrients have anti-inflammatory and qi-regulating effects, can stimulate hair follicles, and accelerate hair growth; it has a strong scavenging effect on free radicals and has anti-aging and antioxidant effects.

[0111] Centella Asiatica extract: Rich in antioxidants, it can reduce hair damage, increase elasticity, and prevent breakage; it has a soothing and calming effect, which can reduce hair loss, while soothing the scalp and building a strong scalp barrier; it can promote cell vitality and help hair growth.

[0112] Rice bran extract (ORYZA SATIVA): It improves skin suppleness by promoting cholesterol and ceramide production and increasing sebum content. Furthermore, it possesses antioxidant properties and can activate glutathione reductase, thus helping to combat aging. These properties enable rice bran extract in shampoos to improve scalp and hair health, reducing hair loss and thinning.

[0113] The use of plant extracts can improve the scalp microenvironment, promote hair follicle health, and enhance cell vitality, thereby achieving the goals of strengthening hair and preventing hair loss.

[0114] For example, a mixture of polydimethylsiloxane alcohol, TEA salt of dodecylbenzenesulfonate and lauryl ether-23 can be used as hair conditioning agent 2.

[0115] in:

[0116] Polydimethylsiloxane alcohol not only has excellent smoothness, but can also penetrate between the hair cuticle layer to form a protective film, making the hair feel softer and smoother, reducing static electricity, reducing friction between hairs and thus reducing tangles, but it can also lock in the natural oils of the hair and scalp, prevent moisture loss, keep the hair moisturized, and reduce dryness and damage caused by shampooing.

[0117] TEA salt of dodecylbenzenesulfonate can effectively promote the dispersion and absorption of other ingredients on the scalp.

[0118] Lauryl ether-23 can improve the stability of shampoo products while helping other ingredients to distribute evenly, ensuring the quality and effectiveness of the shampoo.

[0119] For example, disodium azelaate can be used as a hair conditioning agent.

[0120] Disodium azelaate can inhibit seborrheic dermatitis, help regulate scalp oil secretion, reduce excessive scalp oiliness, and make hair cleaner; it also has a certain antibacterial effect, can competitively inhibit tyrosinase, which helps reduce acne and pimples on the scalp, and can also improve the skin's moisturizing ability, improve scalp elasticity, and make the scalp healthier.

[0121] For example, stearamide propyl dimethylamine can be used as a hair conditioning agent.

[0122] Stearamide propyl dimethylamine can be adsorbed onto the hair surface to form a uniform film, thereby reducing static electricity and friction, making the hair easier to comb, and thus achieving the effect of strengthening the hair.

[0123] For example, guar gum hydroxypropyltrimethylammonium chloride can be used as a hair conditioning agent.

[0124] Guar gum hydroxypropyltrimethylammonium chloride has good water absorption and moisturizing properties, which can provide some moisture to the scalp and hair, improve dryness, and help reduce hair damage, providing a certain degree of hair care effect.

[0125] For example, pyridoxine hydrochloride can be used as a hair conditioning agent.

[0126] Pyridoxine hydrochloride has the effect of inhibiting fungal growth, and can effectively achieve antibacterial and antipruritic effects.

[0127] For example, trihydroxystearin can be used as a hair conditioning agent.

[0128] Trihydroxystearin can make hair smoother, thus achieving a hair care effect.

[0129] For example, polyquaternium-10 can be used as a hair conditioning agent.

[0130] Polyquaternium-10 not only helps reduce dandruff and effectively control fungal growth on the scalp, alleviating scalp itching and inflammation, but it can also form a transparent and continuous film on the skin, providing moisturizing functions and helping to improve damaged skin and repair skin problems.

[0131] The present invention uses a mixture of the above-mentioned 8 hair conditioning agents in shampoo products, which can significantly improve the product's oil control, hair strengthening and anti-hair loss effects.

[0132] (2) The present invention uses a variety of surfactant components, namely a mixture of sodium lauryl ether sulfate and ammonium lauryl sulfate as surfactant components, and controls the mass ratio of the two to be 10-20:3-5, which can significantly improve the cleanliness and foaming performance of the shampoo composition. The resulting composition can foam quickly and produce abundant bubbles, and has good cleanliness. On the other hand, it can also make the active ingredients better dispersed, thus playing a better role.

[0133] (3) In the implementation of this invention, multiple ingredients are combined, which can not only improve hair quality, but also regulate the scalp microecology, so as to achieve the effects of oil control, hair loss prevention and hair strengthening. Detailed Implementation

[0134] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the tables in the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0135] The following examples and comparative examples of the present invention are shown to provide a more detailed description of the compositions of the present invention, but the present invention is not limited thereto.

[0136] The present invention does not limit the source of the raw materials used. Unless otherwise specified, the raw materials used in the present invention are all commercially available products in this technical field.

[0137] This invention provides an oil-controlling, dandruff-removing, anti-hair loss, and hair-strengthening shampoo composition, comprising the following components by weight percentage: 4-10% hair conditioning agent, 1-5% moisturizer, 1-3% thickener, 15-25% surfactant, 0.2-0.6% anti-hair loss agent, 0.1-0.5% dandruff remover, 0.5-1% preservative, 0.3-0.6% fragrance, 0.1-0.3% pH adjuster, 0.02-0.05% colorant, and the balance being water.

[0138] As some preferred embodiments, the hair conditioning agent is present in a weight percentage of 4%, 5%, 6%, 7%, 8%, 9%, or 10%.

[0139] As some preferred embodiments, the humectant is present in a weight percentage of 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, or 5%.

[0140] As some preferred embodiments, the thickener is 1%, 1.5%, 2%, 2.5% or 3% by weight.

[0141] As some preferred embodiments, the surfactant is present in a weight percentage of 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, or 25%.

[0142] As some preferred embodiments, the hair loss prevention agent is present in a weight percentage of 0.2%, 0.3%, 0.4%, 0.5%, or 0.6%.

[0143] As some preferred embodiments, the dandruff-removing agent is present in a weight percentage of 0.1%, 0.2%, 0.3%, 0.4%, or 0.5%.

[0144] As some preferred embodiments, the preservative is present in a weight percentage of 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1.0%.

[0145] As some preferred embodiments, the fragrance agent is present in a weight percentage of 0.3%, 0.4%, 0.5%, or 0.6%.

[0146] As some preferred embodiments, the pH adjuster is present in a weight percentage of 0.1%, 0.15%, 0.2%, 0.25%, or 0.3%.

[0147] As some preferred embodiments, the colorant is present in a weight percentage of 0.02%, 0.03%, 0.04%, or 0.05%.

[0148] in,

[0149] The hair conditioning agent includes hair conditioning agent 1;

[0150] The hair conditioning agent 1 is a mixture of ginger (Zingiber officinale) root extract, ginseng (Panax ginseng) root extract, kelp (Laminaria japonica) extract, pomelo (Citrus grandis) seed extract, centella asiatica (Centella asiatica) extract and rice bran (Oryza sativa) extract.

[0151] Preferably, the hair conditioning agent 1 is purchased from Guangzhou Huayue Medical Aesthetics Research Institute, and its trade name is HYFTGF003.

[0152] The hair conditioning agent also includes hair conditioning agent 2;

[0153] The hair conditioning agent 2 is a mixture of polydimethylsiloxane alcohol, TEA salt of dodecylbenzenesulfonic acid and lauryl alcohol polyether-23.

[0154] Preferably, the hair conditioner 2 is purchased from Guangzhou Boyu Biotechnology Research Co., Ltd., and its trade name is BY6119E.

[0155] The hair conditioning agent also includes hair conditioning agent 3;

[0156] The hair conditioning agent 3 is disodium azelate;

[0157] Preferably, the hair conditioning agent 3 is purchased from Guangzhou Huayue Medical Aesthetics Research Institute, and its trade name is HYDA01.

[0158] The hair conditioning agent also includes hair conditioning agent 4;

[0159] The hair conditioning agent 4 is stearamidopropyl dimethylamine;

[0160] Preferably, the hair conditioner 4 is purchased from Shanghai Zhongxiang Fine Chemical Co., Ltd., and its trade name is S18.

[0161] The hair conditioning agent also includes hair conditioning agent 5;

[0162] The hair conditioning agent 5 is guar gum hydroxypropyltrimethylammonium chloride;

[0163] Preferably, the hair conditioner 5 is purchased from Jingkun Oilfield Chemical Technology Co., Ltd., and its trade name is cationic guar gum JK 140E.

[0164] The hair conditioning agent also includes hair conditioning agent 6;

[0165] The hair conditioning agent 6 is pyridoxine hydrochloride;

[0166] Preferably, the hair conditioner 6 is purchased from DSM Nutritional Products Ltd., under the trade name Pyridoxine Hydrochloride.

[0167] The hair conditioning agent also includes hair conditioning agent 7;

[0168] The hair conditioning agent 7 is trihydroxystearin;

[0169] Preferably, the hair conditioner 7 is purchased from Ambuja Solvex Pvt.LTD., under the trade name THS.

[0170] The hair conditioning agent also includes hair conditioning agent 8, which is polyquaternium-10;

[0171] Preferably, the hair conditioner 8 is purchased from Guangzhou Haoshun Industrial Co., Ltd., and its trade name is [trade name missing].

[0172] As some preferred embodiments, the hair conditioner is a mixture of hair conditioner 1, hair conditioner 2, hair conditioner 3, hair conditioner 4, hair conditioner 5, hair conditioner 6, hair conditioner 7 and hair conditioner 8.

[0173] Preferably, the mass ratio of hair conditioner 1, hair conditioner 2, hair conditioner 3, hair conditioner 4, hair conditioner 5, hair conditioner 6, hair conditioner 7 and hair conditioner 8 is 2-5:1-2:0.5-1.0:0.2-0.5:0.2-0.5:0.1-0.3:0.1-0.2:0.1-0.2;

[0174] More preferably, the mass ratio of hair conditioner 1, hair conditioner 2, hair conditioner 3, hair conditioner 4, hair conditioner 5, hair conditioner 6, hair conditioner 7 and hair conditioner 8 is 3-4:1.5-1.8:0.6-0.8:0.3-0.4:0.3-0.4:0.2-0.3:0.15-0.2:0.15-0.2;

[0175] More preferably, the mass ratio of hair conditioner 1, hair conditioner 2, hair conditioner 3, hair conditioner 4, hair conditioner 5, hair conditioner 6, hair conditioner 7 and hair conditioner 8 is 3:1.7:0.8:0.3:0.3:0.25:0.15:0.15.

[0176] The humectant mentioned is polyquaternium-7;

[0177] Preferably, the moisturizer is purchased from Guangzhou Xingye Technology Co., Ltd., and its trade name is Ucecon M550(A).

[0178] The thickener includes thickener 1;

[0179] The thickener 1 is a mixture of cocamide MEA and glycerin;

[0180] More preferably, the thickener 1 is purchased from Guangdong Keyu New Materials Co., Ltd., and its trade name is KY-CMEA.

[0181] The thickener includes thickener 2;

[0182] The thickener 2 is sodium chloride;

[0183] Preferably, the thickener 2 is purchased from Golmud Shengfu Salt Industry Co., Ltd.

[0184] As some preferred embodiments, the mass ratio of thickener 1 to thickener 2 is 10-15:5-8;

[0185] Preferably, the mass ratio of thickener 1 to thickener 2 is 11-14:6-8;

[0186] More preferably, the mass ratio of thickener 1 to thickener 2 is 12:7.

[0187] The surfactant mentioned includes surfactant 1;

[0188] The surfactant 1 is sodium lauryl ether sulfate;

[0189] Preferably, the surfactant 1 is purchased from Hunan Lichen Aowei Industrial Co., Ltd., and its trade name is RSAWESB70 / ZA.

[0190] The surfactant mentioned includes surfactant 2;

[0191] Preferably, the surfactant 2 is ammonium lauryl sulfate;

[0192] More preferably, the surfactant 2 is purchased from Hunan Lichen Aowei Industrial Co., Ltd., and its trade name is RSAWAL70 / ZA.

[0193] As some preferred embodiments, the surfactant is a mixture of surfactant 1 and surfactant 2;

[0194] Preferably, the mass ratio of surfactant 1 to surfactant 2 is 10-20:3-5;

[0195] More preferably, the mass ratio of surfactant 1 to surfactant 2 is 12-18:3.5-4.5;

[0196] More preferably, the mass ratio of surfactant 1 to surfactant 2 is 12-18:4;

[0197] More preferably, the mass ratio of surfactant 1 to surfactant 2 is 15:4.

[0198] The hair loss prevention agent mentioned is an extract of Thuja orientalis leaves;

[0199] Preferably, the Thuja orientalis leaf extract was purchased from Guangzhou Ganabio Technology Co., Ltd.

[0200] The dandruff remover is pyrrolidone ethanolamine salt;

[0201] Preferably, the pyrrolidone ethanolamine salt is purchased from Shanghai Huanqiu Industrial Development Co., Ltd., and its trade name is OCT.

[0202] The preservative is a mixture of phenoxyethanol and sodium benzoate;

[0203] Preferably, the preservatives are all purchased from Guangdong Dimei New Materials Technology Co., Ltd.

[0204] The fragrance mentioned is a commonly used fragrance in the cosmetics industry.

[0205] The pH adjuster is a mixture of citric acid and arginine.

[0206] The colorant is caramel color, purchased from Shandong Aipu Food Industry Co., Ltd.

[0207] Example 1: An oil-controlling, dandruff-removing, hair-loss-preventing, and hair-strengthening shampoo composition and its preparation method

[0208] Composed of the components in parts by weight as shown in Table 1:

[0209] Table 1

[0210]

[0211]

[0212] The preparation method consists of the following steps:

[0213] (1) Put water with a total water content of 90% and surfactant into a mixing pot, and heat it to 80-85℃ while stirring until the raw materials are completely dissolved to obtain mixture 1;

[0214] (2) Mix thickener 1 and hair conditioner 7, heat to 85°C and stir until dissolved and transparent. Then add hair conditioner 4 and homogenize for 3 minutes at a speed of 45 rpm. Then keep warm for 15 minutes until all the raw materials are dissolved to obtain mixture 2.

[0215] (3) Add hair conditioner 5 and citric acid to water with a total water content of 6% and disperse until there are no lumps. Then homogenize for 3 minutes at a homogenization speed of 45 rpm. Continue stirring at a constant temperature of 85°C for 30 minutes. Then cool down to below 40°C to obtain mixture 3.

[0216] (4) After mixing and dispersing the pyrrolidone ethanolamine salt and the remaining water, add the remaining raw materials in sequence and homogenize for 3 minutes at a homogenization speed of 45 rpm. Stir until there are no solid particles to obtain mixture 4.

[0217] (5) Under the condition of keeping warm at 85°C, add mixture 2 to mixture 1 and stir evenly, then add mixture 3 and stir evenly, then add mixture 4 and continue stirring until evenly mixed, and cool to room temperature to obtain the oil-controlling, dandruff-removing, hair loss-preventing and hair-strengthening shampoo composition.

[0218] Example 2: An oil-controlling, dandruff-removing, hair-loss-preventing, and hair-strengthening shampoo composition and its preparation method

[0219] Composition by weight of the components in Table 2:

[0220] Table 2

[0221]

[0222] The preparation method consists of the following steps:

[0223] (1) Put water with a total water content of 90% and surfactant into a mixing pot, and heat it to 80-85℃ while stirring until the raw materials are completely dissolved to obtain mixture 1;

[0224] (2) Mix thickener 1 and hair conditioner 7, heat to 85°C and stir until dissolved and transparent. Then add hair conditioner 4 and homogenize for 3 minutes at a speed of 45 rpm. Then keep warm for 15 minutes until all the raw materials are dissolved to obtain mixture 2.

[0225] (3) Add hair conditioner 5 and citric acid to water with a total water content of 6% and disperse until there are no lumps. Then homogenize for 3 minutes at a homogenization speed of 45 rpm. Continue stirring at a constant temperature of 85°C for 30 minutes. Then cool down to below 40°C to obtain mixture 3.

[0226] (4) After mixing and dispersing the pyrrolidone ethanolamine salt and the remaining water, add the remaining raw materials in sequence and homogenize for 3 minutes at a homogenization speed of 45 rpm. Stir until there are no solid particles to obtain mixture 4.

[0227] (5) Under the condition of keeping warm at 85°C, add mixture 2 to mixture 1 and stir evenly, then add mixture 3 and stir evenly, then add mixture 4 and continue stirring until evenly mixed, and cool to room temperature to obtain the oil-controlling, dandruff-removing, hair loss-preventing and hair-strengthening shampoo composition.

[0228] Example 3: An oil-controlling, dandruff-removing, hair-strengthening shampoo composition and its preparation method

[0229] Composed of the components in parts by weight as shown in Table 3:

[0230] Table 3

[0231]

[0232]

[0233] The preparation method consists of the following steps:

[0234] (1) Put water with a total water content of 90% and surfactant into a mixing pot, and heat it to 80-85℃ while stirring until the raw materials are completely dissolved to obtain mixture 1;

[0235] (2) Mix thickener 1 and hair conditioner 7, heat to 85°C and stir until dissolved and transparent. Then add hair conditioner 4 and homogenize for 3 minutes at a speed of 45 rpm. Then keep warm for 15 minutes until all the raw materials are dissolved to obtain mixture 2.

[0236] (3) Add hair conditioner 5 and citric acid to water with a total water content of 6% and disperse until there are no lumps. Then homogenize for 3 minutes at a homogenization speed of 45 rpm. Continue stirring at a constant temperature of 85°C for 30 minutes. Then cool down to below 40°C to obtain mixture 3.

[0237] (4) After mixing and dispersing the pyrrolidone ethanolamine salt and the remaining water, add the remaining raw materials in sequence and homogenize for 3 minutes at a homogenization speed of 45 rpm. Stir until there are no solid particles to obtain mixture 4.

[0238] (5) Under the condition of keeping warm at 85°C, add mixture 2 to mixture 1 and stir evenly, then add mixture 3 and stir evenly, then add mixture 4 and continue stirring until evenly mixed, and cool to room temperature to obtain the oil-controlling, dandruff-removing, hair loss-preventing and hair-strengthening shampoo composition.

[0239] Example 4: An oil-controlling, dandruff-removing, anti-hair loss, and hair-strengthening shampoo composition and its preparation method

[0240] Composed of the components in parts by weight as shown in Table 4:

[0241] Table 4

[0242]

[0243]

[0244] The preparation method consists of the following steps:

[0245] (1) Put water with a total water content of 90% and surfactant into a mixing pot, and heat it to 80-85℃ while stirring until the raw materials are completely dissolved to obtain mixture 1;

[0246] (2) Mix thickener 1 and hair conditioner 7, heat to 85°C and stir until dissolved and transparent. Then add hair conditioner 4 and homogenize for 3 minutes at a speed of 45 rpm. Then keep warm for 15 minutes until all the raw materials are dissolved to obtain mixture 2.

[0247] (3) Add hair conditioner 5 and citric acid to water with a total water content of 6% and disperse until there are no lumps. Then homogenize for 3 minutes at a homogenization speed of 45 rpm. Continue stirring at a constant temperature of 85°C for 30 minutes. Then cool down to below 40°C to obtain mixture 3.

[0248] (4) After mixing and dispersing the pyrrolidone ethanolamine salt and the remaining water, add the remaining raw materials in sequence and homogenize for 3 minutes at a homogenization speed of 45 rpm. Stir until there are no solid particles to obtain mixture 4.

[0249] (5) Under the condition of keeping warm at 85°C, add mixture 2 to mixture 1 and stir evenly, then add mixture 3 and stir evenly, then add mixture 4 and continue stirring until evenly mixed, and cool to room temperature to obtain the oil-controlling, dandruff-removing, hair loss-preventing and hair-strengthening shampoo composition.

[0250] Example 5: An oil-controlling, dandruff-removing, hair-strengthening shampoo composition and its preparation method

[0251] Composed of the components in Table 5 by weight:

[0252] Table 5

[0253]

[0254] The preparation method consists of the following steps:

[0255] (1) Put water with a total water content of 90% and surfactant into a mixing pot, and heat it to 80-85℃ while stirring until the raw materials are completely dissolved to obtain mixture 1;

[0256] (2) Mix thickener 1 and hair conditioner 7, heat to 85°C and stir until dissolved and transparent. Then add hair conditioner 4 and homogenize for 3 minutes at a speed of 45 rpm. Then keep warm for 15 minutes until all the raw materials are dissolved to obtain mixture 2.

[0257] (3) Add hair conditioner 5 and citric acid to water with a total water content of 6% and disperse until there are no lumps. Then homogenize for 3 minutes at a homogenization speed of 45 rpm. Continue stirring at a constant temperature of 85°C for 30 minutes. Then cool down to below 40°C to obtain mixture 3.

[0258] (4) After mixing and dispersing the pyrrolidone ethanolamine salt and the remaining water, add the remaining raw materials in sequence and homogenize for 3 minutes at a homogenization speed of 45 rpm. Stir until there are no solid particles to obtain mixture 4.

[0259] (5) Under the condition of keeping warm at 85°C, add mixture 2 to mixture 1 and stir evenly, then add mixture 3 and stir evenly, then add mixture 4 and continue stirring until evenly mixed, and cool to room temperature to obtain the oil-controlling, dandruff-removing, hair loss-preventing and hair-strengthening shampoo composition.

[0260] Example 6: An oil-controlling, dandruff-removing, anti-hair loss, and hair-strengthening shampoo composition and its preparation method

[0261] Composed of the components in Table 6 by weight:

[0262] Table 6

[0263]

[0264]

[0265] The preparation method consists of the following steps:

[0266] (1) Put water with a total water content of 90% and surfactant into a mixing pot, and heat it to 80-85℃ while stirring until the raw materials are completely dissolved to obtain mixture 1;

[0267] (2) Mix thickener 1 and hair conditioner 7, heat to 85°C and stir until dissolved and transparent. Then add hair conditioner 4 and homogenize for 3 minutes at a speed of 45 rpm. Then keep warm for 15 minutes until all the raw materials are dissolved to obtain mixture 2.

[0268] (3) Add hair conditioner 5 and citric acid to water with a total water content of 6% and disperse until there are no lumps. Then homogenize for 3 minutes at a homogenization speed of 45 rpm. Continue stirring at a constant temperature of 85°C for 30 minutes. Then cool down to below 40°C to obtain mixture 3.

[0269] (4) After mixing and dispersing the pyrrolidone ethanolamine salt and the remaining water, add the remaining raw materials in sequence and homogenize for 3 minutes at a homogenization speed of 45 rpm. Stir until there are no solid particles to obtain mixture 4.

[0270] (5) Under the condition of keeping warm at 85°C, add mixture 2 to mixture 1 and stir evenly, then add mixture 3 and stir evenly, then add mixture 4 and continue stirring until evenly mixed, and cool to room temperature to obtain the oil-controlling, dandruff-removing, hair loss-preventing and hair-strengthening shampoo composition.

[0271] Example 7: An oil-controlling, dandruff-removing, anti-hair loss, and hair-strengthening shampoo composition and its preparation method

[0272] Composed of the components in parts by weight as shown in Table 7:

[0273] Table 7

[0274]

[0275]

[0276] The preparation method consists of the following steps:

[0277] (1) Put water with a total water content of 90% and surfactant into a mixing pot, and heat it to 80-85℃ while stirring until the raw materials are completely dissolved to obtain mixture 1;

[0278] (2) Mix thickener 1 and hair conditioner 7, heat to 85°C and stir until dissolved and transparent. Then add hair conditioner 4 and homogenize for 3 minutes at a speed of 45 rpm. Then keep warm for 15 minutes until all the raw materials are dissolved to obtain mixture 2.

[0279] (3) Add hair conditioner 5 and citric acid to water with a total water content of 6% and disperse until there are no lumps. Then homogenize for 3 minutes at a homogenization speed of 45 rpm. Continue stirring at a constant temperature of 85°C for 30 minutes. Then cool down to below 40°C to obtain mixture 3.

[0280] (4) After mixing and dispersing the pyrrolidone ethanolamine salt and the remaining water, add the remaining raw materials in sequence and homogenize for 3 minutes at a homogenization speed of 45 rpm. Stir until there are no solid particles to obtain mixture 4.

[0281] (5) Under the condition of keeping warm at 85°C, add mixture 2 to mixture 1 and stir evenly, then add mixture 3 and stir evenly, then add mixture 4 and continue stirring until evenly mixed, and cool to room temperature to obtain the oil-controlling, dandruff-removing, hair loss-preventing and hair-strengthening shampoo composition.

[0282] Example 8: An oil-controlling, dandruff-removing, hair-strengthening shampoo composition and its preparation method

[0283] Composed of the components in Table 8 by weight:

[0284] Table 8

[0285]

[0286]

[0287] The preparation method consists of the following steps:

[0288] (1) Put water with a total water content of 90% and surfactant into a mixing pot, and heat it to 80-85℃ while stirring until the raw materials are completely dissolved to obtain mixture 1;

[0289] (2) Mix thickener 1 and hair conditioner 7, heat to 85°C and stir until dissolved and transparent. Then add hair conditioner 4 and homogenize for 3 minutes at a speed of 45 rpm. Then keep warm for 15 minutes until all the raw materials are dissolved to obtain mixture 2.

[0290] (3) Add hair conditioner 5 and citric acid to water with a total water content of 6% and disperse until there are no lumps. Then homogenize for 3 minutes at a homogenization speed of 45 rpm. Continue stirring at a constant temperature of 85°C for 30 minutes. Then cool down to below 40°C to obtain mixture 3.

[0291] (4) After mixing and dispersing the pyrrolidone ethanolamine salt and the remaining water, add the remaining raw materials in sequence and homogenize for 3 minutes at a homogenization speed of 45 rpm. Stir until there are no solid particles to obtain mixture 4.

[0292] (5) Under the condition of keeping warm at 85°C, add mixture 2 to mixture 1 and stir evenly, then add mixture 3 and stir evenly, then add mixture 4 and continue stirring until evenly mixed, and cool to room temperature to obtain the oil-controlling, dandruff-removing, hair loss-preventing and hair-strengthening shampoo composition.

[0293] Comparative Example 1

[0294] The difference from Example 1 is that hair conditioner 1 is not added, and the content of hair conditioner 2 is increased to 4.7%, while the rest is the same as in Example 1.

[0295] Comparative Example 2

[0296] The difference from Example 1 is that the mass ratio of hair conditioner 1, hair conditioner 2, hair conditioner 3, hair conditioner 4, hair conditioner 5, hair conditioner 6, hair conditioner 7, and hair conditioner 8 is 8:0.5:0.3:0.1:0.1:0.6:0.2:0.2, as shown in Table 9 below:

[0297] Table 9

[0298]

[0299] Everything else is the same as in Example 1.

[0300] Comparative Example 3

[0301] The difference from Example 1 is: the mass ratio of hair conditioner 1, hair conditioner 2, hair conditioner 3, hair conditioner 4, hair conditioner 5, hair conditioner 6, hair conditioner 7 and hair conditioner 8 is 0.5:5:0.1:2:2:0.05:0.05:0.3, which is specifically shown in Table 10 below:

[0302] Table 10

[0303]

[0304]

[0305] The rest is the same as Example 1.

[0306] Comparative Example 4

[0307] The difference from Example 1 is: the mass ratio of surfactant 1 and surfactant 2 is 4:15, which is specifically shown in Table 11 below:

[0308] Table 11

[0309] Surfactant 1 RSAW ESB70 / ZA 4％ Surfactant 2 RSAW AL70 / ZA 15％

[0310] The rest is the same as Example 1.

[0311] Performance test:

[0312] I. Irritation test

[0313] 1. Acute eye irritation test

[0314] 1.1 Materials and methods

[0315] (1) Test substance:

[0316] The samples prepared in Examples 1-8 and Comparative Examples 1-4 are directly used as the test substances in their original state.

[0317] (2) Laboratory animals and feeding environment:

[0318] Laboratory animals: 24 New Zealand rabbits (conventional grade, female, body weight 2.0-2.5kg), animal certificate number: NO.44411600015747.

[0319] Animal source: Purchased from Guangdong Provincial Medical Laboratory Animal Center (Sanshui Base), Laboratory Animal Production License No.: SCXK (Yue) 2023-0035.

[0320] Feeding environment: Conventional environment, temperature 21.7-23.2℃, relative humidity 62.7-65.4RH%, Laboratory Animal Environment Use License No.: SYXK (Yue) 2023-0216.

[0321] Feed: Provided by Jiangquan Feed Factory of Linyi Shengquan Oil and Chemical Co., Ltd., License No.: Lu Feed Certificate (2024) 16062, Quality Certificate No.: NO.2024071600177.

[0322] The eyes of the animals were examined within 24 hours prior to the experiment (including examination with sodium fluorescein), and no eye irritation symptoms were found.

[0323] (3) Test methods:

[0324] Twenty-four animals were selected and divided into 12 groups of two. The lower eyelid of the right eye of each rabbit was gently pulled open, and 100 mg of the test substance was instilled into the conjunctival sac. The upper and lower eyelids were passively closed for 1 second. At 30 seconds, the eyes were rinsed with a sufficient flow of water at a relatively fast rate that would not cause eye damage for 30 seconds. The left eye was left untreated as a self-control. The animals' eyes were examined using a magnifying glass and a pupillary pen light at 1 hour, 24 hours, 48 ​​hours, 72 hours, 4 days, and 7 days after instillation of the test substance. Simultaneously, after 24 hours of observation and recording, all animals' eyes were examined with sodium fluorescein at each examination. Eye irritation reactions were recorded and scored according to Table 1, Part 5, Chapter 6 of the "Cosmetic Safety Technical Specifications" (2015 edition). If no irritation reaction was observed after 72 hours, the experiment was terminated. If corneal involvement or other eye irritation was observed that did not recover within 7 days, the observation period was extended to 21 days, and observation reports for 7 days, 14 days, and 21 days were provided.

[0325] 1.2 Test Results:

[0326] See Table 12 below.

[0327] Table 12 Results of the acute eye irritation test on rabbits by the test substances.

[0328]

[0329]

[0330] 1.3 Experimental Conclusions

[0331] The results of the acute eye irritation test of the test substance on rabbits were as follows: Under the condition of rinsing for 30 seconds, the highest average score of the test substance on rabbit eyes was 0 for the cornea, iris, and conjunctiva, and the average score for the cornea, iris, and conjunctiva was 0 after 24 hours, indicating that it was non-irritating.

[0332] 2. Acute skin irritation test

[0333] 2.1 Materials and Methods

[0334] (1) Test substance:

[0335] The samples prepared in Examples 1-8 and Comparative Examples 1-4 are directly used as the test substance in their original state.

[0336] (2) Laboratory animals and feeding environment:

[0337] Laboratory animals: 24 New Zealand rabbits (conventional grade, male, body weight 2.1-2.4kg), animal certificate number: NO.430730241100198434.

[0338] Animal source: Purchased from Hunan Taiping Biotechnology Co., Ltd., Laboratory Animal Production License No.: SCXK(Xiang)2023-0011.

[0339] Feeding environment: Conventional environment, temperature 21.7-22.5°C, relative humidity 63.1-63.8RH%, Laboratory Animal Environment Use License No.: SYXK(Xiang)2023-0216.

[0340] Feed: Provided by Jiangquan Feed Mill of Linyi Shengquan Oil and Chemical Co., Ltd., License No.: Lu Feed Certificate (2024) 16062, Quality Certificate No.: NO.2024061500223.

[0341] (3) Test method:

[0342] 24 adult, healthy rabbits with intact skin are divided into 12 groups, 2 rabbits in each group. 24 hours before the test, the back hair on both sides of the spine of each rabbit is cut off without damaging the epidermis, and the depilated area on each of the left and right sides is 3cm×3cm.

[0343] During the test, 0.5g of the test substance is applied to the left skin, then covered with two layers of gauze (2.5cm×2.5cm) and one layer of cellophane, and then fixed with non-irritating adhesive tape and bandage. The right skin is coated with an equal amount of distilled water as control. A 2-hour application test is adopted. After the test, the residual test substance is removed with warm water. Skin reactions at the application site are observed at 1h, 24h, 48h and 72h after the removal of the test substance. The skin irritation reactions are scored according to Table 1 in Part 4, Chapter 6 of the Safety and Technical Standards for Cosmetics (2015 Edition), and the skin irritation intensity is judged based on the mean value of the highest scores at each observation time point of 24h, 48h and 72h.

[0344] 2.2 Test results

[0345] See Table 13 below.

[0346] Table 13 Results of acute skin irritation test of test substance on rabbits

[0347]

[0348]

[0349] 2.3 Experimental Conclusions

[0350] The results of the acute skin irritation test on rabbits were as follows: the highest average score of the acute skin irritation of the test substance on rabbits was 0, which is classified as non-irritating according to the skin irritation intensity grading.

[0351] II. Detection of 5α-reductase inhibition

[0352] 2.1 Experimental Objective and Principle:

[0353] Seborrhea is a disorder of sebaceous gland secretion, resulting in excessive sebum production. This leads to an accumulation of oil on the skin and hair, making it appear oily and shiny, and causing excessive flaking. Hormonal imbalances, primarily elevated androgen levels, can also cause increased sebum secretion. Androgens, androgen receptors, and the activity of androgen-metabolizing enzymes can all affect sebum secretion.

[0354] There are two types of androgen-metabolizing enzymes, 5α-reductase. Type I is distributed in the liver and sebaceous glands, while type II is mainly found in the gonadal tissues, scalp, and hair follicles. Testosterone and its reducing coenzyme NADPH are converted to dihydrotestosterone (DHT) under the action of 5α-reductase. DHT's binding activity to androgen receptors is five times that of testosterone, promoting cellular processes and inducing increased sebum secretion from sebaceous glands. The activity of 5α-reductase can affect sebum secretion in different parts of the body.

[0355] Based on this principle, this experiment used ultraviolet spectrophotometry to determine 5α-reductase activity, using changes in the concentration of reducing coenzymes to reflect 5α-reductase activity. Finally, the degree of inhibition of 5α-reductase activity by the experimental samples was used to preliminarily judge the oil-controlling effect of the cosmetics; the higher the inhibition rate of 5α-reductase, the stronger the oil-controlling effect of the substance, and vice versa.

[0356] 2.2 Judgment Criteria:

[0357] The higher the 5α-reductase activity inhibition rate, the stronger the oil-controlling effect of the substance.

[0358] 2.3 Test Methods:

[0359] (1) Sample preparation;

[0360] (2) The sample was reacted with a solution containing 5α-reductase, etc.

[0361] (3) Measure absorbance at 340 nm;

[0362] (4) Calculate the inhibition rate of 5α-reductase activity.

[0363] The sample preparation for this experiment was as follows: Weigh 2g of sample, add Tris buffer to 10ml, shake well to disperse, sonicate for 10min, centrifuge at 5000r / min for 5min, and take the supernatant for the experiment.

[0364] The negative control was a 5α-reductase reaction system, which was incubated at 37°C for 30 min.

[0365] 2.4 Experimental Results:

[0366] The absorbance measurements at different times are shown in Table 14, and the results of the 5α-reductase activity inhibition rate test are shown in Table 15.

[0367] Table 14

[0368]

[0369]

[0370] in,

[0371] Formula for calculating ΔA:

[0372] ΔA = A(0min) - A(60min)

[0373] Formula for calculating the inhibition rate of 5α-reductase activity:

[0374] 5α-Reductase activity inhibition rate (%) = (ΔA0 - ΔAn) / ΔA0 × 100%

[0375] In the formula: ΔA1 - the difference in absorbance in the negative test

[0376] ΔA2 - Difference in absorbance of the sample

[0377] Table 15

[0378] Example 1 Sample 55.8％ Example 2 Sample 41.5％ Example 3 Sample 37.6％ Example 4 Sample 45.5％ Example 5 Sample 48.1％ Example 6 Sample 50.1％ Example 7 Sample 46.8％ Example 8 Sample 49.4％ Comparative Example 1 Sample 24.7％ Comparative Example 2 Sample 28.6％ Comparative Example 3 Sample 27.3％ Comparative Example 4 Sample 35.1％

[0379] According to the test results in Tables 14 and 15 above, the shampoo compositions prepared in Examples 1-8 of the present invention all have good 5α-reductase inhibition effects, with inhibition rates all above 37%, and the highest reaching above 55%, indicating that the shampoo compositions prepared in Examples 1-8 of the present invention all have good oil control effects.

[0380] Omitting hair conditioning agent 1 in Comparative Example 1, i.e. reducing the mixture of ginger (Zingiber officinale) root extract, ginseng (Panax ginseng) root extract, kelp (Laminaria japonica) extract, grapefruit (Citrus grandis) seed extract, centella asiatica (Centella asiatica) extract, and rice bran (Oryza sativa) extract, significantly affects the 5α-reductase inhibition effect of the shampoo composition, resulting in a significant decrease in the inhibition rate.

[0381] In Comparative Examples 2-3, changing the mass ratio of hair conditioning agent 1, hair conditioning agent 2, hair conditioning agent 3, hair conditioning agent 4, hair conditioning agent 5, hair conditioning agent 6, hair conditioning agent 7, and hair conditioning agent 8 is not within the scope of protection of this invention and may also affect the 5α-reductase inhibition effect of the shampoo composition to a certain extent, thus reducing the inhibition rate.

[0382] In Comparative Example 4, changing the mass ratio of the surfactant is not within the scope of protection of this invention. It will affect the dispersion of the active ingredient, which will affect the 5α-reductase inhibition effect of the shampoo composition to a certain extent, thus reducing the inhibition rate.

[0383] In summary, only shampoo compositions prepared using the formula of this invention have better oil control, hair strengthening, and hair loss prevention effects.

[0384] III. Hair Loss Prevention Efficacy Test

[0385] 3.1 Test product: The sample prepared in Example 1.

[0386] 3.2 Control product: The corresponding test product base formula (white viscous liquid) without anti-hair loss active ingredients was tested in parallel with the test product.

[0387] 3.3 Product during the elution period: Similar to the control product, both the experimental and control groups used the control product during the elution period.

[0388] 3.4 Subjects: The number of valid subjects who completed the test was 66. The planned number of subjects in the experimental group was 33, and the actual number of valid subjects was 33. The planned number of subjects in the control group was 33, and the actual number of valid subjects was 33. There were 49 males and 17 females, aged 19 to 53 years, with an average age of 32 ± 9.1 years, which met the subject voluntary inclusion criteria.

[0389] 3.5 Test Equipment: Professional digital camera; pixel count not less than 15 megapixels, with consistent parameters including aperture, ISO, and focal length throughout the test; Image capture stand: A device capable of fixing the subject's head, ensuring the top of the head is perpendicular to the camera lens, and using the professional digital camera to capture full-head hair photographs centered on the top of the head; Dermatoscope: LED light source, wavelength 450-750nm, color temperature 6500-8000k, illuminance not less than 540lx, magnification ≥20x, detection diameter not less than 1.0cm or area not less than 0.8cm. 2 Combs: The combs should have moderate tooth density (tooth spacing 0.9-1.1mm), tooth length 2.0-3.0cm, and comb length no less than 10cm (excluding the comb handle). The same specification and material of combs must be used throughout the entire test. After each use, disinfection should be carried out in accordance with the relevant requirements in the "Technical Specifications for Disinfection of Medical Institutions" (WS-T367-2012).

[0390] 3.6 Experimental Methods: The testing was conducted according to the specific requirements of the "Cosmetic Safety Technical Specifications" (2015 edition). Volunteer subjects were recruited according to the inclusion and exclusion criteria. Hair loss was counted using the 60-comb test and recorded. Eligible subjects underwent a 2-week shampooing period. After the shampooing period, the 60-comb test was performed again; only subjects with a hair loss count greater than 10 strands were eligible for the formal trial. Subjects were randomly assigned to either the experimental product group or the control product group. Pre-experimental hair basal values ​​were assessed in subjects, including hair loss count, hair density assessment, and image capture, and the results were recorded. The product was used continuously for 12 weeks according to the instructions. The same assessment and testing were repeated at 4, 8, and 12 weeks of product use.

[0391] 3.7 Statistical Methods

[0392] Statistical analysis software was used to perform statistical analysis on the data. Quantitative data were expressed as mean ± standard deviation and subjected to normality testing to ensure they met the requirements of a normal distribution. Comparisons before and after data were performed using a ratio t-test; comparisons of graded materials before and after use were performed using a two-sample rank-sum test; comparisons between experimental samples and the control group were performed using an independent samples t-test or a rank-sum test. All statistical analyses were two-tailed tests, with a significance level of α = 0.05.

[0393] 3.8 Data Analysis

[0394] See Table 16-17 below.

[0395] Table 16. Significance analysis of the test product at different time points before and after use.

[0396]

[0397] Note: "NS" indicates P ≥ 0.05, no significant difference; "S" indicates P < 0.05, significant difference.

[0398] Table 17. Significance Analysis of the Differences Between the Test Product and the Control Product Before and After Use

[0399]

[0400]

[0401] Note: "NS" indicates P ≥ 0.05, no significant difference; "S" indicates P < 0.05, significant difference.

[0402] 3.9 Experimental Conclusion:

[0403] The results of the anti-hair loss efficacy test showed that after 4, 8, and 12 weeks of use, there was no significant increase in hair loss count compared to week 0; and after 12 weeks of use, there was a significant decrease in hair loss count (P < 0.05). After 4, 8, and 12 weeks of use, there was no significant decrease in overall hair density compared to week 0; and after 4, 8, and 12 weeks of use, there was no significant decrease in local hair density compared to week 0.

[0404] Compared with the control product, the experimental product showed a significant decrease in hair loss count after 4, 8, and 12 weeks of use (P < 0.05); compared with the control product, the experimental product showed a significant increase in overall hair density after 8 weeks of use (P < 0.05); and compared with the control product, the experimental product showed a significant increase in local hair density after 8 and 12 weeks of use (P < 0.05). This indicates that the experimental sample has anti-hair loss effects.

[0405] Obviously, the described embodiments are only individual embodiments of the present invention, and not all embodiments. All other implementations obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the protection scope of the present invention.

Claims

1. A shampoo composition for oil control, dandruff removal, and hair loss prevention, characterized in that: The product is composed of the following components by weight percentage: HYFTGF003 3%; BY6119E 1.7%; HYDA01 0.8%; S18 0.3%; cationic guar gum JK140E 0.3%; Pyridoxine Hydrochloride 0.25%; THS 0.15%; CHCOGUM®JR400 0.15%; Ucecon M550(A) 2%; KY-CMEA 1.2%; sodium chloride 0.7%; RSAW ESB70 / ZA 15%; RSAW AL70 / ZA 4%; Platycladus orientalis leaf extract 0.4%; OCT 0.3%; phenoxyethanol 0.5%; sodium benzoate 0.4%; fragrance 0.5%; citric acid 0.2%; arginine 0.004%; caramel color 0.04%; and water balance. The main components of HYFTGF003 are a mixture of ginger root extract, ginseng root extract, kelp extract, grapefruit seed extract, centella asiatica extract and rice bran extract; The main components of BY6119E are a mixture of polydimethylsiloxane alcohol, TEA salt of dodecylbenzenesulfonic acid and lauryl alcohol polyether-23; The main component of HYDA01 is disodium azelate; The main component of S18 is stearamide propyl dimethylamine; The main component of the cationic guar gum JK140E is guar gum hydroxypropyltrimethylammonium chloride; The main component of the Pyridoxine Hydrochloride is pyridoxine hydrochloride; The main component of the aforementioned THS is trihydroxystearin; The main component of CHCOGUM®JR400 is polyquaternium-10; The main component of the Ucecon M550(A) is polyquaternium-7; The main component of the KY-CMEA is a mixture of cocamide MEA and glycerin; The main component of RSAW ESB70 / ZA is sodium lauryl ether sulfate; The main component of RSAW AL70 / ZA is ammonium lauryl sulfate.

2. The preparation method of the oil-controlling, dandruff-removing, anti-hair loss, and hair-strengthening shampoo composition according to claim 1, characterized in that: Includes the following steps: (1) Put water with a total water content of 90%, RSAW ESB70 / ZA and RSAW AL70 / ZA into a mixing pot, and heat to 80-85℃ while stirring until all the raw materials are dissolved to obtain mixture 1; (2) Mix KY-CMEA and THS and heat to 85°C. Stir until dissolved and transparent. Then add S18 and homogenize for 3 minutes at a speed of 45 rpm. Then keep warm for 15 minutes until all the raw materials are dissolved to obtain mixture 2. (3) Add cationic guar gum JK140E and citric acid to water with a total water content of 6% and disperse until there are no lumps. Then homogenize for 3 minutes at a homogenization speed of 45 rpm and continue stirring at a constant temperature of 85°C for 30 minutes. Then cool down to below 40°C to obtain mixture 3. (4) After mixing and dispersing OCT and the remaining water, add the remaining raw materials in sequence and homogenize for 3 minutes at a homogenization speed of 45 rpm. Stir until there are no solid particles to obtain mixture 4. (5) Under the condition of keeping warm at 85°C, add mixture 2 to mixture 1 and stir evenly, then add mixture 3 and stir evenly, then add mixture 4 and continue stirring until evenly mixed, and cool to room temperature to obtain the oil-controlling, dandruff-removing, hair loss-preventing and hair-strengthening shampoo composition.

3. The application of the oil-controlling, dandruff-removing, anti-hair loss, and hair-strengthening shampoo composition according to claim 1 in the preparation of shampoo products with oil-controlling, dandruff-removing, anti-hair loss, and hair-strengthening properties, characterized in that: The hair care product mentioned is shampoo, hair lotion, or hair cream.

4. A shampoo, characterized in that: It includes the oil-controlling, dandruff-removing, anti-hair loss and hair-strengthening shampoo composition as described in claim 1 and the excipients used in preparing the shampoo.

5. A shampoo, characterized in that: Includes the oil-controlling, dandruff-removing, anti-hair loss and hair-strengthening shampoo composition as described in claim 1 and the excipients used in preparing the shampoo.

6. A shampoo, characterized in that: Includes the oil-controlling, dandruff-removing, anti-hair loss and hair-strengthening shampoo composition as described in claim 1 and the excipients used in preparing the shampoo.

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