A warm-up behavior test box

Abstract

The present application relates to the technical field of mouse testing, in particular to a warm behavior test box, comprising a bearing assembly including a box body; and a supporting assembly including a turnover frame rotatably arranged in the box body, a connecting frame integrally formed at an end of the turnover frame, and a rotating plate movably connected with the connecting frame; and a test frame and a test stand detachably arranged inside the box body; wherein a camera is movably arranged on the turnover frame, and a first heating plate is arranged at an opening of an outer wall of the rotating plate, the warm behavior test box provided by the present application not only provides an environment with conditions such as illumination, temperature and humidity, but also adjusts the position of the camera for recording by arranging the turnover frame, so as to realize standardized collection and quantitative analysis of behavior data. When different tests are carried out, the mouse does not need to be transported into each special box body, which provides a reliable basis for preclinical research, drug safety evaluation and the like.

Description

Technical Field

[0001] This invention relates to the field of mouse testing technology, and in particular to a temperature-controlled behavior testing chamber. Background Technology

[0002] In modern scientific research, mice are one of the most commonly used model animals in biomedical research. Their physiological characteristics, genetic background and behavioral responses are highly similar to those of humans. By precisely controlling the breeding environment and behavioral testing conditions, mice can provide stable and reliable experimental models for disease mechanism research, drug development, neurobiology and other fields.

[0003] Different behavioral experiments have specific requirements for environmental conditions and data acquisition methods. For example, sleep EEG recording and open field experiments require a top-down camera to record the overall activity of mice, while forced swimming and tail suspension experiments require a camera at eye level to record specific behavioral details. Precise environmental control and targeted image acquisition methods can meet the needs of these experiments, thereby obtaining accurate and reliable experimental data. This helps researchers gain a deeper understanding of mouse behavioral patterns, physiological responses, and related disease mechanisms, providing important reference data for biomedical research and drug development.

[0004] Therefore, we propose a chamber that meets various mouse testing conditions. Summary of the Invention

[0005] In view of the problems existing in the prior art, the present invention is proposed.

[0006] To solve the above-mentioned technical problems, the present invention provides the following technical solution: a temperature-controlled behavior testing chamber, comprising: a carrying component including a chamber body; and a supporting component including a flip frame rotatably disposed within the chamber body, a connecting frame integrally formed at the end of the flip frame, and a rotating plate movably connected to the connecting frame; and a test frame and a test rack detachably disposed within the chamber body; wherein, a camera is movably disposed on the flip frame, and a first heating plate is disposed at the opening on the outer wall of the rotating plate.

[0007] As a preferred embodiment of the temperature control behavior test chamber of the present invention, the outer wall of the chamber is provided with a plurality of heat dissipation fans, the inner wall of the chamber is provided with a heat insulation board, the opening of the outer wall of the chamber is provided with a door, and the outer wall of the chamber is provided with a mounting plate.

[0008] As a preferred embodiment of the temperature control behavior test chamber of the present invention, the outer wall of the flipping frame is provided with a movable channel, and the inner wall of the movable channel is provided with a sliding groove, and the outer wall of the flipping frame is provided with a positioning through hole communicating with the sliding groove.

[0009] In a preferred embodiment of the temperature control behavior test chamber of the present invention, the camera component includes a connecting plate and a camera disposed on the connecting plate, wherein a rotating frame for supporting the camera is rotatably disposed within the connecting plate via a rotating shaft.

[0010] As a preferred embodiment of the temperature control behavior test chamber of the present invention, the end face of the connecting plate is provided with a supplementary light, and the two side walls of the connecting plate are respectively bolted with side wing plates that slide in cooperation with the slide groove, and the side wing plates are provided with insert plates that are movably connected to the positioning through holes.

[0011] In a preferred embodiment of the temperature control behavior test chamber of the present invention, a control plate is movably provided on the outer wall of the side wing plate, and one end of the insert plate is connected to the control plate.

[0012] As a preferred embodiment of the temperature control behavior test chamber of the present invention, it further includes a fixing component, including two clamping plates symmetrically arranged on the inner end face of the chamber, and the end face of the clamping plate is provided with a slot for fixing the test frame.

[0013] As a preferred embodiment of the temperature control behavior test chamber of the present invention, a fixed frame is installed inside the chamber by bolts, and a transmission block is movably arranged inside the fixed frame. A second elastic element is provided between the transmission block and the inner wall of the fixed frame.

[0014] As a preferred embodiment of the temperature control behavior test chamber of the present invention, wherein: a limiting channel is provided inside the clamping plate, and a first elastic element is provided in the limiting channel; a movable block is also slidably provided in the limiting channel; the outer wall of the movable block extends to the outside of the clamping plate and is provided with a rotating rod.

[0015] In a preferred embodiment of the temperature control behavior test chamber of the present invention: a support channel is provided through the outer wall of the rotating rod; the end of the transmission block is movably connected to the support channel; there are two rotating rods, which are arranged in a cross shape, and one end of each rotating rod is connected to the adjacent clamping plate; a positioning screw is mounted on the end face of the transmission block through a bearing, and one end of the positioning screw extends to the outside of the fixed frame; a nut that is threadedly engaged with the positioning screw is embedded in the outer wall of the fixed frame.

[0016] The beneficial effects of this invention are as follows: The temperature-controlled behavioral testing chamber provided by this invention not only provides an environment with suitable light, temperature, and humidity, but also allows for adjustment of the camera position for recording through a flip-up frame, enabling standardized collection and quantitative analysis of behavioral data. Furthermore, it eliminates the need to transfer mice to separate specialized chambers during different tests, providing reliable data for preclinical research and drug safety evaluation. Attached Figure Description

[0017] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort. Wherein:

[0018] Figure 1 This is a schematic diagram of the overall structure of the present invention.

[0019] Figure 2 This is a schematic diagram of the internal structure of the box in this invention.

[0020] Figure 3 This is a schematic diagram of the test frame and test fixture structure in this invention.

[0021] Figure 4 This is a schematic diagram of the supporting component structure in this invention.

[0022] Figure 5 This is a schematic diagram of the camera structure in this invention.

[0023] Figure 6 This is a schematic diagram of the first state of the flipping frame structure in this invention.

[0024] Figure 7 This is a schematic diagram of the second state of the flipping frame structure in this invention.

[0025] Figure 8 This is a schematic diagram of the fixed component structure in this invention.

[0026] In the diagram: 10. Load-bearing component; 11. Cabinet; 111. Cooling fan; 112. Mounting plate; 113. Insulation plate; 12. Cabinet door; 20. Support component; 21. Flip frame; 211. Connecting frame; 212. Movement channel; 213. Slide; 213-1. Positioning through hole; 22. Rotating plate; 221. First heating plate; 23. Camera; 231. Connecting plate; 232. Camera; 233. Rotating frame ; 234, Side wing plate; 235, Control board; 236, Insert plate; 237, Fill light; 30, Test frame; 31, Test rack; 40, Fixing assembly; 41, Clamping plate; 411, Slot; 412, Limiting channel; 413, First elastic element; 414, Movable block; 42, Rotating rod; 421, Support channel; 43, Fixing frame; 431, Transmission block; 432, Second elastic element; 44, Positioning screw. Detailed Implementation

[0027] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

[0028] Many specific details are set forth in the following description in order to provide a full understanding of the invention. However, the invention may also be practiced in other ways different from those described herein, and those skilled in the art can make similar extensions without departing from the spirit of the invention. Therefore, the invention is not limited to the specific embodiments disclosed below.

[0029] Secondly, the term "one embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The phrase "in one embodiment" appearing in different places in this specification does not necessarily refer to the same embodiment, nor is it a single or selective embodiment that is mutually exclusive with other embodiments.

[0030] Example 1, referring to Figures 1 to 8 This is the first embodiment of the present invention.

[0031] Specifically, the supporting component 10 includes a housing 11; and the supporting component 20 includes a flip frame 21 rotatably disposed within the housing 11, a connecting frame 211 integrally formed at the end of the flip frame 21, and a rotating plate 22 movably connected to the connecting frame 211; and a test frame 30 and a test rack 31 detachably disposed inside the housing 11; wherein, a camera 23 is movably disposed on the flip frame 21, and a first heating plate 221 is disposed at the opening on the outer wall of the rotating plate 22. A second heating plate and a full-spectrum LED light are also disposed on the side wall of the housing 11.

[0032] Preferably, the outer wall of the enclosure 11 is provided with a plurality of cooling fans 111, and the inner wall of the enclosure 11 is provided with an insulation board 113. The outer wall opening of the enclosure 11 is provided with a door 12, and the outer wall of the enclosure 11 is provided with a mounting plate 112. To meet the ventilation requirements of the enclosure, two cooling fans 111 are provided, and ventilation is provided for 15 minutes per hour.

[0033] The chamber 11 is also equipped with a humidifier and a humidity controller to maintain the humidity inside the chamber 11 within a suitable range for mouse rearing (50%-60%).

[0034] According to the experimental design and the temperature requirements for feeding and behavioral testing, temperature controllers were set up to control the cooling module and the heating module to achieve the specified temperature and temperature change pattern. The heating module consists of two silicone heating plates, namely the first heating plate 221 and the second heating plate, with the temperature of each heating plate set to 70℃ to meet the requirements for the heating rate.

[0035] In normal mode:

[0036] 1. Lighting and ventilation settings: Based on the diurnal rhythm characteristics of mice (12-hour light-dark cycle), the full-spectrum LED lights are set to turn off at 7:00 AM and 7:00 PM every day; to meet the ventilation requirements of the enclosure, two cooling fans (one for suction and one for exhaust) are set up to ventilate for 15 minutes per hour.

[0037] 2. Humidity and temperature settings: Set the humidity controller to 50%-60%; according to the experimental design and the required feeding temperature, set the temperature controller to control the cooling module and the heating module respectively to achieve the specified temperature and temperature change mode, and the two heating plates are working.

[0038] 3. Image acquisition: The top camera 23 records from a top-down perspective.

[0039] Example 2, refer to Figures 1 to 8 This is the second embodiment of the present invention.

[0040] Specifically, the outer wall of the tilting frame 21 has a through-hole 212, and the inner wall of the through-hole 212 has a groove 213. The outer wall of the tilting frame 21 has a positioning through-hole 213-1 that communicates with the groove 213. The through-hole 213-1 facilitates the rotation of the rotating plate 22 and avoids movement conflicts between the rotating plate 22 and the tilting frame 21.

[0041] The camera component 23 includes a connecting plate 231 and a camera 232 mounted on the connecting plate 231. A rotating frame 233 for supporting the camera 232 is rotatably mounted inside the connecting plate 231 via a pivot. The rotating frame 233 can support the camera 233 to rotate up to a maximum angle of 180°.

[0042] A supplementary light 237 is provided on the end face of the connecting plate 231, and side wing plates 234 that slide in conjunction with the slide groove 213 are respectively installed on the two side walls of the connecting plate 231 by bolts. An insert plate 236 that is movably connected to the positioning through hole 213-1 is provided inside the side wing plate 234. The supplementary light 237 can meet the lighting requirements of the camera 232 when recording video. The sliding fit between the side wing plate 234 and the slide groove 213 allows the camera 232 to meet the needs of head-up video recording at different heights. A control plate 235 is movably provided on the outer wall of the side wing plate 234, and one end of the insert plate 236 is connected to the control plate 235.

[0043] It should be noted that a compression spring is provided at one end of the insert plate 236. When the two control plates 235 move relative to each other, the compression spring is stressed. When the insert plate 236 disengages from the positioning through hole 213-1, the position of the camera 23 can be moved.

[0044] This type of test kit meets various behavioral testing requirements, namely:

[0045] 1. Sleep EEG recording, open field test, elevated cruciate test, Y maze, three-box social simulation, etc.

[0046] Under this type of behavioral test, see Figure 6 Based on the diurnal rhythm characteristics of mice (12-hour light-dark cycle), the full-spectrum LED lights were set to turn off at 7:00 AM and 7:00 PM daily; to ensure adequate ventilation in the enclosure, two fans (one for suction and one for exhaust) were installed, ventilating for 15 minutes per hour; the humidity controller was set to 50%-60%; according to the experimental design and the required rearing temperature, temperature controllers were installed to control the cooling and heating modules to achieve the specified temperature and temperature change mode, with the left and right heating plates operating.

[0047] For image acquisition, the camera 232 on the top of the housing 11 records from a top-down perspective.

[0048] 2. Forced swimming, tail suspension test, etc.

[0049] Under this type of behavioral test, see Figure 7 Based on the circadian rhythm of mice (a 12-hour light-dark cycle), the full-spectrum LED lights were set to turn off at 7:00 AM and 7:00 PM daily. To ensure adequate ventilation, two fans (one for suction and one for exhaust) were installed, providing ventilation for 15 minutes per hour. A humidity controller was set to maintain 50%-60% humidity. According to the experimental design and required rearing temperature, a temperature controller was installed to separately control the cooling and heating modules to achieve the specified temperature and temperature change patterns. Heating plates on the top and side of chamber 11 were also activated. For image acquisition, a camera 232 on the side wall of chamber 11 recorded data from a head-on perspective.

[0050] It should be noted that when the camera 232 needs to record from a top-down perspective, the flip frame 21 can be rotated to the top of the inner cavity of the housing 11, and the rotating plate 22 can be flipped so that the first heating plate 221 is located on one side wall of the housing 11, thereby meeting the temperature requirements. When the camera 232 needs to record from a level perspective, the flip frame 21 can be flipped to a vertical state, the rotating plate 22 can be flipped to a horizontal state, and the height of the camera 232 can be controlled to meet the level-up requirement.

[0051] Example 3, referring to Figures 1 to 8 This is the third embodiment of the present invention.

[0052] Specifically, it also includes a fixing component 40, which includes two clamping plates 41 symmetrically arranged on the inner end face of the housing 11. The end face of the clamping plates 41 is provided with a slot 411 for fixing the test frame 31. The fixing component 40 can fix the test frame 30 and the test frame 31.

[0053] A fixed frame 43 is bolted to the inside of the housing 11, and a transmission block 431 is movably disposed within the fixed frame 43. A second elastic element 432 is disposed between the transmission block 431 and the inner wall of the fixed frame 43. The second elastic element 432 is a compression spring.

[0054] The clamping plate 41 has a limiting channel 412 inside, and a first elastic element 413 is provided in the limiting channel 412. A movable block 414 is also slidably arranged in the limiting channel 412. The outer wall of the movable block 414 extends to the outside of the clamping plate 41 and is provided with a rotating rod 42. The first elastic element 413 is also a compression spring, and each clamping plate 41 has a slidable movable block 414 in the limiting channel 412.

[0055] A support channel 421 is provided through the outer wall of the rotating rod 42. The end of the transmission block 431 is movably connected to the support channel 421. There are two rotating rods 42, which are arranged in a cross shape. One end of each rotating rod 42 is connected to the adjacent clamping plate 41. A positioning screw 44 is installed on the end face of the transmission block 431 through a bearing. One end of the positioning screw 44 extends to the outside of the fixed frame 43. A nut that is threaded with the positioning screw 44 is embedded in the outer wall of the fixed frame 43.

[0056] In summary, when it is necessary to fix the test frame 30, the test frame 30 can be placed between the two clamping plates 41, and by rotating the positioning screw 44, with the cooperation of the nut, the positioning screw 44 gradually moves out of the fixing frame 43. At the same time, the transmission block 431 will also move synchronously. It should be noted that a bearing is provided between the positioning screw 44 and the transmission block 431. That is, the rotation of the positioning screw 44 will not drive the transmission block 431 to rotate, but only cause the transmission block 431 to move.

[0057] The transmission block 431 pulls the two clamping plates 41 closer together through the support channel 421 on the rotating rod 42, thus fixing the test frame 30. When it is necessary to fix the test frame 31 so as to use the test frame 31 to perform tail suspension tests on mice, the test frame 31 can be clipped into the slot 411 at the upper end of the clamping plate 41.

[0058] Finally, it should be noted that the methods and devices described in detail above are merely embodiments, and those skilled in the art can modify these embodiments in different ways as long as they do not depart from the scope of the present invention.

Claims

1. A temperature-controlled behavior testing chamber, characterized in that: include, The load-bearing component (10) includes a housing (11); and, The support component (20) includes a flipping frame (21) rotatably disposed within the housing (11), a connecting frame (211) integrally formed at the end of the flipping frame (21), and a rotating plate (22) movably connected to the connecting frame (211); and, The test frame (30) and test fixture (31) are detachably disposed inside the housing (11); wherein, A camera (23) is movably mounted on the flipping frame (21), and a first heating plate (221) is provided at the opening on the outer wall of the rotating plate (22). When the camera (232) needs to record from a top-down perspective, the flip frame (21) can be rotated to the top of the inner cavity of the box (11), and the rotating plate (22) can be flipped so that the first heating plate (221) is located on one side wall of the box (11) to meet the temperature requirements; when the camera (232) needs to record from a level perspective, the flip frame (21) can be flipped to a vertical state, the rotating plate (22) can be flipped to a horizontal state, and the height of the camera (232) can be controlled to meet the level view requirement; The outer wall of the flipping frame (21) is provided with a movable channel (212), and the inner wall of the movable channel (212) is provided with a sliding groove (213). The outer wall of the flipping frame (21) is provided with a positioning through hole (213-1) that communicates with the sliding groove (213). It also includes a fixing component (40), which includes two clamping plates (41) symmetrically arranged on the inner end face of the housing (11), and the end face of the clamping plate (41) is provided with a slot (411) for fixing the test frame (31). The box (11) is fitted with a fixed frame (43) by bolts, and a transmission block (431) is movably arranged inside the fixed frame (43). A second elastic element (432) is provided between the transmission block (431) and the inner wall of the fixed frame (43). The clamping plate (41) has a limiting channel (412) inside, and a first elastic element (413) is provided in the limiting channel (412). A movable block (414) is also slidably provided in the limiting channel (412). The outer wall of the movable block (414) extends to the outside of the clamping plate (41) and is provided with a rotating rod (42).

2. The temperature control behavior testing chamber as described in claim 1, characterized in that: The outer wall of the box (11) is provided with a plurality of cooling fans (111), and the inner wall of the box (11) is provided with a heat insulation board (113). The outer wall opening of the box (11) is provided with a door (12), and the outer wall of the box (11) is provided with an installation plate (112).

3. The temperature-controlled behavior testing chamber as described in claim 1, characterized in that: The camera component (23) includes a connecting plate (231) and a camera (232) mounted on the connecting plate (231). A rotating frame (233) for supporting the camera (232) is rotatably mounted inside the connecting plate (231) via a rotating shaft.

4. The temperature control behavior testing chamber as described in claim 3, characterized in that: The end face of the connecting plate (231) is provided with a supplementary light (237), and the two side walls of the connecting plate (231) are respectively bolted with side wing plates (234) that slide in cooperation with the slide groove (213). The side wing plates (234) are provided with insert plates (236) that are movably connected to the positioning through hole (213-1).

5. The temperature control behavior testing chamber as described in claim 4, characterized in that: A control plate (235) is movably provided on the outer wall of the side wing plate (234), and one end of the insert plate (236) is connected to the control plate (235).

6. The temperature control behavior testing chamber as described in claim 1, characterized in that: The outer wall of the rotating rod (42) is provided with a support channel (421). The end of the transmission block (431) is movably connected to the support channel (421). There are two rotating rods (42), which are cross-shaped. One end of each rotating rod (42) is connected to the adjacent clamping plate (41). The end face of the transmission block (431) is equipped with a positioning screw (44) through a bearing. One end of the positioning screw (44) extends to the outside of the fixed frame (43). The outer wall of the fixed frame (43) is embedded with a nut that has a threaded engagement with the positioning screw (44).

Images