颗粒物料的停留时间分布检测方法、装置、设备及介质
By using sample collection containers and tracers in continuous granulation processes in the pharmaceutical industry, combined with visual resolution features and flow error correction, the consistency and stability issues in batch granulation processes are resolved, improving the accuracy of residence time distribution detection and production efficiency.
CN120489879BActive Publication Date: 2026-07-17ZHEJIANG UNIV
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- ZHEJIANG UNIV
- Filing Date
- 2025-07-08
- Publication Date
- 2026-07-17
Smart Images
Figure CN120489879B_ABST
Abstract
本申请涉及固体制粒技术领域，公开了一种颗粒物料的停留时间分布检测方法、装置、设备及介质，包括：在制粒过程达到预设状态的情况下，向颗粒物料中加入示踪剂，得到含有示踪剂的制粒样本；利用样本收集容器连续收集制粒样本，直至样本收集容器中垂直堆积的制粒样本的视觉分辨特征达到预设视觉特征要求，得到收集样本；对收集样本进行图像采集，得到样品分析图像；根据样品分析图像的视觉特征分布数据进行停留时间分布分析，得到初始检测结果；根据制粒过程中颗粒物料的实际流量对初始检测结果进行流量误差校正，得到停留时间分布检测结果。其有益效果在于，通过对制粒样本的连续收集以及流量误差校正，有效提升了停留时间分布检测的准确性。
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