Gene methylation markers and uses thereof
The use of real-time quantitative PCR to detect ELTD1 gene methylation markers has solved the problems of invasiveness and insufficient sensitivity in the early diagnosis of lung cancer, and achieved efficient and non-invasive lung cancer detection and monitoring.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT)
- Filing Date
- 2025-04-03
- Publication Date
- 2026-07-14
AI Technical Summary
Existing methods for early diagnosis of lung cancer are highly invasive, making it difficult to obtain multiple samples. Furthermore, traditional imaging methods lack sensitivity and specificity, making it impossible to effectively detect early lesions and resulting in incomplete diagnosis.
Using the ELTD1 gene methylation marker, the methylation patterns of circulating cell-free DNA and exosomal DNA are detected, and quantitative real-time PCR is used for the diagnosis, screening, monitoring, and efficacy evaluation of lung cancer. Combined with plasma exosomal DNA extraction and transformation reagents, non-invasive detection is achieved.
It improves the detection rate of lung cancer, is easy to operate, and has simple results interpretation. It has high sensitivity and high specificity and is suitable for the early diagnosis and dynamic monitoring of lung cancer.
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